1X4J,4V3K


Conserved Protein Domain Family
RING-H2_RNF38_like

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cd16472: RING-H2_RNF38_like 
Click on image for an interactive view with Cn3D
RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
The family includes RING finger proteins RNF38, RNF44, and similar proteins. RNF38 is a nuclear E3 ubiquitin protein ligase that plays a role in regulating p53. RNF44 is an uncharacterized RING finger protein that shows high sequence similarity with RNF38. Both RNF38 and RNF44 contain a coiled-coil motif, a KIL motif (Lys-X2-Ile/Leu-X2-Ile/Leu, X can be any amino acid), and a C3H2C3-type RING-H2 finger. In addition, RNF38 harbors two potential nuclear localization signals.
Statistics
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PSSM-Id: 319386
View PSSM: cd16472
Aligned: 11 rows
Threshold Bit Score: 85.9946
Threshold Setting Gi: 806394279
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #  #              # #  #  #          #  # 
1X4J_A         23 QTLCVVCMCDFEsrqlLRVLPCNHEFHAKCVDKWLkanrtCPICR 67   human
Q7L0R7        377 QTLCVVCFSDFEarqlLRVLPCNHEFHTKCVDKWLkanrtCPICR 421  human
XP_003728567  459 QTCCVVCMSDFEtrqtLRVLPCSHEFHARCVDKWLksnrtCPICR 503  purple sea urchin
KHN85276      410 EKVCVVCQCDFEkrdhVRVLPCDHHYHVKCVDKWLktnrtCPICR 454  dog roundworm
4V3K_C         24 QTLCVVCMCDFEsrqlLRVLPCNHEFHAKCVDKWLkanrtCPICR 68   human
KPM10790      562 QTMCVICMYEFEakqnLRVLPCHHEFHVRCIDKWLktnrtCPICR 606  Sarcoptes scabiei
XP_013383249  564 QTSCVVCMCDFEqkqqLRVLPCSHEFHIKCVDKWLksnrtCPICR 608  Lingula anatina
EDV22736      478 SKGCVICMSDFEdidcLRVLMCKHEFHTSCIDRWLktnrtCPICR 522  Trichoplax adhaerens
NP_649902     769 QSSCVVCMCDFElrqlLRVLPCSHEFHAKCVDKWLrsnrtCPICR 813  fruit fly
XP_002734949  505 QTCCVVCMCDFEqrqlLRVLTCNHEFHTKCVDKWLktnrtCPICR 549  Saccoglossus kowalevskii
EKC33083     1758 QTSCVVCMCDFEnrqlLRVLPCSHEFHAKCVDKWLktnrtCPICR 1802 Pacific oyster

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