1H6F,4A04,5BQD,1XBR


Conserved Protein Domain Family
T-box

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pfam00907: T-box (this model, PSSM-Id:307177 is obsolete and has been replaced by 395727)
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T-box
The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.
Statistics
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PSSM-Id: 307177
Aligned: 123 rows
Threshold Bit Score: 157.706
Threshold Setting Gi: 308456726
Created: 14-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1H6F_A         7 VHLEAKELWDQFHKRGTEMVITKS-GRRMFPPFKVRCSGLDKKAKYILLMDIIAADDC----RYKFHNSRWMV------- 74  human
O02073       169 ISLANQEQWAKFHEIGTEMMVFNS-GRRLFPLLAYKVSGLDPHKLYCAGVHMIPDSAYkqeyDHD--LQQWVNclnqkkt 245 Caenorhabditis ...
Q20257         9 LSSTTDPLWRSCHEYDNEMVITVN-GRRIFPTLEYTVTGLDTFKLYSMCMHLDLVDDK----KLRFTGGQWAE------- 76  Caenorhabditis ...
XP_003111560  54 LSSNTDALWRNCFELTNEMNITAP-GRRVFPTLEYIVTGLDPSKYYVISMHFEFMDDK----KLRFVGGKWTE------- 121 Caenorhabditis ...
XP_003095069  14 VSLSNQEQWEKFYPH-TEMVVTRKsGRLLFPHLKYILKGLDEDTEYSVFLHFERIDNW----KYKFLSRGWDK------- 81  Caenorhabditis ...
XP_003103799   9 VSLSNQDQWEKFHPM-TEMVVTRKaGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNI----KYKFSVNKWKE------- 76  Caenorhabditis ...
XP_003103790   9 VSLSNQDQWEKFHPM-TEMIVTRKaGRRLFPHLNYILKGLDPNELYGVFIHFERVDKN----RYQFLRNKWNV------- 76  Caenorhabditis ...
XP_003110726  12 ISLSDKKTWNEFYPK-TEMIVTKKkGRVIFPHLNYNLKGMEPGTLYTVHIHLERVDNI----KYKFDAGEWQE------- 79  Caenorhabditis ...
XP_002641342  12 LSLADSKTWKKFYPN-TEMIVTKRkGRVIFPHLNYNLTGLEPNAHYEVFIHLERTDDK----KYKFDAGKWQD------- 79  Caenorhabditis ...
XP_002630399   9 VTLNNAGLWKKFNSP-MEMILTKKiGRKMFPNLEYSVDGLNPTAMYEIYLHMERMDDH----KYRYVSKEWDD------- 76  Caenorhabditis ...
1H6F_A        75 -AGK-AD-PEmPK-RMYIHPDSPAT---GEQWMSKVVTFHKLKLTN---------NISDK--H--GFTI---LNSMHKYQ 131 human
O02073       246 iFKPtSEiL--------------GRienGFKLMSLGIDMSDVKIFNiairkktplQIEKSrkPnlD--KtieVLIQYKYL 309 Caenorhabditis ...
Q20257        77 -SVS-TEkK--DPpRKVWHHNGSQT---GKDWMLRNVSFDQIRITN---------RKSKEdgNasY-VH---LLTQHRYI 136 Caenorhabditis ...
XP_003111560 122 -SPS-TEeK--GVpRIVFHKDGAQL---GKDWMDKPLSFDQIRVTN---------RKSDQhkGpsF-VY---LLTQHRYI 181 Caenorhabditis ...
XP_003095069  82 -WTE-GD-KK-LPiDMKQHKDEWKC---GRDWMKDPVSFDYIKITN---------NTEAKk-E--NEIL---LQSMHRYL 139 Caenorhabditis ...
XP_003103799  77 -FAK-GD-EI-RPiERKLHKDGWRL---GGHWMENPVSFEYFKITN---------DPEMDk-D--DAVL---VQSMHKHI 134 Caenorhabditis ...
XP_003103790  77 -FGK-SD-EV-RHiKVEQHLDGWRA---GSYWMTKPVSFEHVKITN---------NPDLKk-S--NTFV---LQSMHKFK 134 Caenorhabditis ...
XP_003110726  80 -FGK-GE-PV-HPiKYKEHPDGARP---GSHWMKETVSFSHLKITN---------DAENKd-N--KLIL---VQSMHKYR 137 Caenorhabditis ...
XP_002641342  80 -FGK-GD-KM-LPiEYKQHPDGARA---GSHWMKETLSFQHLKITN---------NPENTd-K--KLIV---VQSMHKFR 137 Caenorhabditis ...
XP_002630399  77 -YAR-GD-PI-TPiQKIKHKSGGQT---GMFWMDGPISFEQIRLTN---------NPETEk-K--DHIC---LQSMHKWR 134 Caenorhabditis ...
1H6F_A       132 PRFHIVR----ANDILkLPYSTFRTYL--FPETEFIAVTAYQNDKITQLKIDNNPFAKGFRD 187 human
O02073       310 PVIKIYElsnsGMEKKeI-----AQAT--FPETSFVTVSIYRNQKIKEMKTLGNKYCRTDRK 364 Caenorhabditis elegans
Q20257       137 PVLTIY-------------EGDQLVHTarIPHSQFISVTAYHKGELNTLKTNNNPYSTGSRK 185 Caenorhabditis elegans
XP_003111560 182 PVLTIL-------------EGDQIVHIskIDYTSFITVTAYHNNALNQLKTENNPYATGSRQ 230 Caenorhabditis remanei
XP_003095069 140 PVISIQK----KG------GMEKEEFR--LGITEFMAVTTYQNNSIASLKVELNQHASGFRQ 189 Caenorhabditis remanei
XP_003103799 135 PVLSIQR----EN------AEK-EEFR--FGVTEFMAVTAYQNKNIIQLKIEMNRFASGFKE 183 Caenorhabditis remanei
XP_003103790 135 PVIGVQK----MG------DSKIEGFR--LDVTEFMAVTAYQNNDIKELKIQMNRFASGFKE 184 Caenorhabditis remanei
XP_003110726 138 PVVTITK----HG------GYPGEEFR--LALTEFIVVTAYQSDEMIKLKVAHNKFASGFRS 187 Caenorhabditis remanei
XP_002641342 138 PVITIKK----TN------EQMGEQFR--LNITEFYVVTAYQCEEIIRLKVSHNKFASGFRS 187 Caenorhabditis briggsae
XP_002630399 135 PVVTIRKle-nGD-ENsDFD---EEFR--IENVWFMAVTTYQNPAIKVLKVENNKFASGFRS 189 Caenorhabditis briggsae
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