Conserved Protein Domain Family
IlGF_relaxin_like

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cd04365: IlGF_relaxin_like 
IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), and insulin-like peptides 5 (INSL5) and 6 (INSL6). Members of this subgroup are widely expressed in testes (INSL3, INSL6), decidua, placenta, prostate, corpus luteum, brain (various relaxins), GI tract, and kidney (INSL5) where they serve a variety of functions in parturition and development. Typically, the active forms of these peptide hormones are composed of two chains (A and B) linked by two disulfide bonds; the arrangement of four cysteines is conserved in the "A" chain: Cys1 is linked by a disulfide bond to Cys3, Cys2 and Cys4 are linked by interchain disulfide bonds to cysteines in the "B" chain. This alignment contains both chains, plus the intervening linker region, arranged as found in the propeptide form. Propeptides are cleaved to yield two separate chains linked covalently by the two disulfide bonds.
Statistics
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PSSM-Id: 239831
View PSSM: cd04365
Aligned: 46 rows
Threshold Bit Score: 46.9301
Threshold Setting Gi: 91076980
Created: 24-Aug-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
receptor
Feature 1:receptor binding surface
Evidence:
  • Comment:consensus between relaxin and INSL3 receptor binding sites
  • Comment:determined via alanine substitutions for INSL3
  • Comment:determined via alanine substitutions for relaxin

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #   #  #                                                                  
P04090     31 VIKLCGRELVRAQIAICGMSTWSKrslsqedapqtprpvaeivpsfinkdtetinmmsefvanlpqelkltlsemqpalp 110 human
NP_002186  27 ELRGCGPRFGKHLLSYCPMPEKTFtttpggwllesgrpkemvstsnnkdgq----------------------------- 77  human
CAC16108   29 GIRLCGRDFIRTVVMSCGGSRWKRyspepgqersnpnrdfldwlnrasledpdrlnsly--------------------- 87  edible frog
NP_570070  59 THSRCRDKLVRQLYWACEKDIYRLtrrnkkrtgndeawik---------------------------------------- 98  fruit fly
NP_446132  25 RAKLCGHHLVRALVRVCGGPRWSPeatqpvdtrdrellqwleqrhl---------------------------------- 70  Norway rat
AAH71706   30 REKLCGHHFVRALVRVCGGPRWSTearrpaaggdrellqwlerrh----------------------------------- 74  human
XP_426669  26 AVKLCGRDFVRAIVFTCGGSRWKRdlanyqyllaiacaagklysddnnwrkkkmaessessp------------------ 87  chicken
CAJ44436   26 RVKLCGREFVRTVVASCGSFRVKRsmpdsdlhfaypyrnlqnwldrdlvvhqrgspaved-------------------- 85  zebrafish
ABF55951   36 GVKLCGREFIRAVIFTCGGSRWKRstdgdldpldwsslseetaeddpqtwqqlsesrsplp------------------- 96  Japanese medaka
EAT45764   55 SHSRCRDKLIRHLYWACEKDIYRIsrrnddygggngavgkra-------------------------------------- 96  yellow fever mosquito
Feature 1                                                                                  
P04090    111 qlqqhvpvlkdssllfeefkklirnrqseaadsspselkyLGLDTHSRKKRql-ySALANKCCHV-GCTKRSLARFC 185 human
NP_002186  78 --------------algttsefipnlspelkkplsegqpsLKKIILSRKKRsg-rHRFDPFCCEV-ICDDGTSVKLC 138 human
CAC16108   88 -----aeshmapnppfsslqkddptmeqlhgalydplvteEQQGVGLRMKRs---AGPALSCCQR-GCTKNELMKFC 155 edible frog
NP_570070  99 ------------------------ktttepdgstwlhvnyANMFLRSRRSDgn-tPSISNECCTKaGCTWEEYAEYC 150 fruit fly
NP_446132  71 -------------------lhalvadadpaldpdpaldpqLPHQASQRQRRsv-aTNAVHRCCLT-GCTQQDLLGLC 126 Norway rat
AAH71706   75 --------------------llhglvadsnltlgpglqplPQTSHHHRHHRaa-aTNPARYCCLS-GCTQQDLLTLC 129 human
XP_426669  88 --sssqesgasaepspfaaqwlraadeqsqegraqeerdvQRSRKVAVLKRrevaKLLTTSCCSV-GCSERDISLLC 161 chicken
CAJ44436   86 -----eqwrerdtpesvrghpdprqhtsppaepldhsttmQDLSVSSRSRRd---AGPAGVCCTS-GCTMNELIQYC 153 zebrafish
ABF55951   97 ----alpsysltdllslfrstgdreqpplrrhaaseeergNEQRLTSKKKRnf-sLGVAGMCCNQ-GCTKNDIGRLC 167 Japanese medaka
EAT45764   97 -----------------------nalpflarwtiskeqaqSFLRTRRTGKRrs-gGSITAECCTRvGCTWEEYAEYC 149 yellow fever mosquito

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