1NIS,1L5J,1AMI,1C97,7ACN,8ACN


Conserved Protein Domain Family
Aconitase_swivel

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cd00404: Aconitase_swivel 
Click on image for an interactive view with Cn3D
Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme mechanism. The aconitase family contains the following proteins: - Iron-responsive element binding protein (IRE-BP). IRE-BP is a cytosolic protein that binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5'UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'UTR of transferrin receptor mRNA. IRE-BP also express aconitase activity. - 3-isopropylmalate dehydratase (isopropylmalate isomerase), the enzyme that catalyzes the second step in the biosynthesis of leucine. - Homoaconitase (homoaconitate hydratase), an enzyme that participates in the alpha-aminoadipate pathway of lysine biosynthesis and that converts cis-homoaconitate into homoisocitric acid.
Statistics
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PSSM-Id: 238236
Aligned: 11 rows
Threshold Bit Score: 57.8633
Threshold Setting Gi: 15596456
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
substrate
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:substrate binding site [chemical binding site]
Evidence:
  • Structure:1L5J_A binds aconitase; contacts at 3.5A
    View structure with Cn3D
  • Comment:These residues participate in the active site of the catalytic domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1NIS      560 KVKGKCTTDHISAAGpwlkfrghldnisnnlligainsenrk---------------------------ansvrnavtqe 612 cow
1L5J_A    172 KVTGETNTDDLSPAPdawsrpdiplhalamlknaregi------------------------------------epdqpg 215 Escherichia coli
1AMI      560 KVKGKCTTDHISAAGpwlkfrghldnisnnlligainsenrk---------------------------ansvrnavtqe 612 Bos taurus
1C97_A    559 KVKGKCTTDHISAAGpwlkfrghldnisnnlligainienrk---------------------------ansvrnavtqe 611 cow
7ACN      560 KVKGKCTTDHISAAGpwlkfrghldnisnnlligainienrk---------------------------ansvrnavtqe 612 pig
8ACN      560 KVKGKCTTDHISAAGpwlkfrghldnisnnlligainsenrk---------------------------ansvrnavtqe 612 Bos taurus
AAG15207   38 FLGDSITTDHISPAGsikvnspagkyliehgvapadfnsygarrgnhevmvrgtfanvrlrnklapgteggfttylptge 117 Chloroflexus auran...
NP_214222 480 IVEDNITTDHIMPAGakilplrsniyaiseyvyh--------------------------------------------yv 515 Aquifex aeolicus VF5
NP_661513  11 VLGKNIDTDQIIPAEhlvyslsdpeevkmygkyalsgv------------------------------------pidqag 54  Chlorobium tepidum...
P49367    519 CDADNINTDGIYPGKytyqddvpkekmaqv-------------------------------------------------- 548 baker's yeast
NP_249950  12 LVAGSASGELLYAPTglsfwggvdprsae--------------------------------------------------- 40  Pseudomonas aerugi...
Feature 1                                   ###                                               
1NIS      613 fgpvpdtaryykqhgiRWVVIGd-eNYGEGSSREHRAl-EPRFLGGr------------AIITKSFARIHETNLKKQg-- 676 cow
1L5J_A    216 vvgpikqiealqqkgfPLAYVGd--VVGTGSSRKSATn-SVLWFMGddiphvpnkrgggLCLGGKIAPIFFNTMEDAg-- 290 Escherichia coli
1AMI      613 fgpvpdtaryykqhgiRWVVIGd-eNYGEGSSREHSAl-EPRFLGGr------------AIITKSFARIHETNLKKQg-- 676 Bos taurus
1C97_A    612 fgpvpdtaryykqhgiRWVVIGd-eNYGEGASREHSAl-EPRHLGGr------------AIITKSFARIHETNLKKQg-- 675 cow
7ACN      613 fgpvpdtaryykqhgiRWVVIGd-eNYGEGSSREHSAl-EPRHLGGr------------AIITKSFARIHETNLKKQg-- 676 pig
8ACN      613 fgpvpdtaryykqhgiRWVVIGd-eNYGEGSSREHSAl-EPRFLGGr------------AIITKSFARIHETNLKKQg-- 676 Bos taurus
AAG15207  118 vmtiydaamryqadgtPLVVIAg-kEYGNGSSRDWAAk-GPYLQGVk------------AVIAESFERIHRSNLVGMg-- 181 Chloroflexus auran...
NP_214222 516 dpefvprmkklkekgkAGIIIGg-eNYGQGSSREHAAl-APRFLGVr------------AVIAKSFARIHHANLVNFg-- 579 Aquifex aeolicus VF5
NP_661513  55 lpegnipfveegeftsPYSIIIagpNFGCGSSREHAPf-ALKVAGAk------------AIIAESYARIFYRNCVDGgfv 121 Chlorobium tepidum...
P49367    549 -cmenydaefrtkvhpGDIVVSg-fNFGTGSSREQAAt-ALLAKGIn------------LVVSGSFGNIFSRNSINNa-- 611 baker's yeast
NP_249950  41 ---vidrhhplsgrhlHGRLLAi--PGGRGSCTGSSVllELILGGRapaaillrepdeiLALGAIVAEELFGRSLPIa-- 113 Pseudomonas aerugi...
Feature 1                                              
1NIS      677 -----lLPLtfadpady-----------nkihpvdkLTIQG 701 cow
1L5J_A    291 -----aLPIevdvsn---------------lnmgdvIDVYP 311 Escherichia coli
1AMI      677 -----lLPLtfadpady-----------nkihpvdkLTIQG 701 Bos taurus
1C97_A    676 -----lLPLtfadpady-----------nkihpvdkLTIQG 700 cow
7ACN      677 -----lLPLtfadpady-----------nkihpvdkLTIQG 701 pig
8ACN      677 -----lLPLtfadpady-----------nkihpvdkLTIQG 701 Bos taurus
AAG15207  182 -----iVPLqfmpgenaa---------slgltghevYDVIG 208 Chloroflexus aurantiacus
NP_214222 580 -----vVPLefknkedy-----------dkfslgdeIEIPN 604 Aquifex aeolicus VF5
NP_661513 122 ipfetaQPLnksim------------------tgdeLSLDM 144 Chlorobium tepidum TLS
P49367    612 -----lLTLeipalikklrekyqgapkeltrrtgwfLKWDV 647 baker's yeast
NP_249950 114 -----cLGErf-----------------------deLAAYP 126 Pseudomonas aeruginosa PAO1

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