3M7O,3MTX,1NEP,2Z64,1A9V,1PU5


Conserved Protein Domain Family
ML

?
smart00737: ML 
Click on image for an interactive view with Cn3D
Domain involved in innate immunity and lipid metabolism.
ML (MD-2-related lipid-recognition) is a novel domain identified in MD-1, MD-2, GM2A, Npc2 and multiple proteins of unknown function in plants, animals and fungi. These single-domain proteins were predicted to form a beta-rich fold containing multiple strands, and to mediate diverse biological functions through interacting with specific lipids.
Statistics
?
PSSM-Id: 214796
Aligned: 50 rows
Threshold Bit Score: 62.7697
Threshold Setting Gi: 15225294
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
3M7O_A        42 YQSCD--PLQDFGLSIDQ-------CS-----K-------QIQSNLNIRFGIILRQDIRKLFLDITLMAKgsSI--LNYS 98  house mouse
NP_608637     21 FSDCGskTGKFTRVAIEG-------CD-----TtkaecilKRNTTVSFSIDFALAEEATAVKTVVHGKVLgiEMpfPLAN 88  fruit fly
Q25481        19 YTDCGskLATVQSVGVSGwpenareCV-----L-------KRNSNVTISIDFSPTTDVSAITTEVHGVIMslPVpfPCRS 86  tobacco hornworm
NP_775331     24 FVDCGsvdGKVVQVDIKP-------CSqqpckL-------HKGQSYTVNVTFSSGVESQTSKAVVHGVLAgvPVpfPIPI 89  zebrafish
P58755        34 YSYCDs-MKFPFSITAEP-------CI-----T-------LKGTNGFLHIKFIPRRDLKKLYFNLSINVNsiEVptRKEI 93  Chinese hamster
NP_001098426  34 YNYCDd-MKFPISVKVEP-------CV-----T-------IKGTKGKLHLYYIARRDIQKLYLNLHISIKsmTLpmRKE- 92  pig
NP_058619     34 YSYCDh-LKFPISISSEP-------CI-----R-------LRGTNGFVHVEFIPRGNLKYLYFNLFISVNsiEl--PKRK 91  house mouse
3MTX_A        21 YKSCD--PQQDFAFSIDR-------CS-----D-------VTTHTFDIRAAMVLRQSIKELYAKVDLIINgkTVlsYSET 79  chicken
EAW55191      71 YQSCD--PLQDFGFSVEK-------CS-----K-------QLKSNINIRFGIILREDIKELFLDLALMSQgsSV--LNFS 127 human
2Z64_C        14 YSYCDh-LKFPISISSEP-------CI-----R-------LRGTNGFVHVEFIPRGNLKYLYFNLFISVNsiEl--PKRK 71  house mouse
3M7O_A        99 YPLCEE---D---QpkfSFCGRRKGEQIYYAGPv-NN-P-G-LdVPQGEYQLLLELY-NEn-RAT-VACANATV 159 house mouse
NP_608637     89 PDACVD---S---G---LKCPLEKDESYRYTATl-PV-L-R-S-YPKVSVLVKWELQ-DQd-GAD-IICVEIPA 145 fruit fly
Q25481        87 PDACKD---N---G---LTCPIKAGVVANYKTTl-PV-L-K-S-YPKVSVDVKWELK--Kd-EED-LVCILIPA 142 tobacco hornworm
NP_775331     90 DDGCKS-------G---IQCPIVPQKPYNYVTEl-PV-K-T-E-YPAIKVVVEWELR-DDs-SKD-LFCIKFPV 145 zebrafish
P58755        94 --ICHG---YddnY---SFCKALKGETVNTVVPf-SF-K-G-IlFPKGQYRCVAEAIvGDn-EEK-LFCLNFTI 153 Chinese hamster
NP_001098426  93 -VICREyggD---Y---SFCGALKGETVNTTIPfsFQ-G-I-R-FSPGQYHCVVEAI-SGn-SEEmLFCLNFTI 153 pig
NP_058619     92 EVLCHGhddD---Y---SFCRALKGETVNTSIPfsFE-G-I-L-FPKGHYRCVAEAI-AGdtEEK-LFCLNFTI 153 house mouse
3MTX_A        80 --LCGP---GlskL---IFCGKKKGEHLYYEGPi-TL-GiK-E-IPQRDYTITARLT-NEd-RAT-VACADFTV 138 chicken
EAW55191     128 YPICEA---A---LpkfSFCGRRKGEQIYYAGPv-NN-P-EfT-IPQGEYQVLLELY-TEk-RST-VACANATI 188 human
2Z64_C        72 EVLCHGhddD---Y---SFCRALKGETVNTSIPf-SFeG-I-L-FPKGHYRCVAEAI-AGdtEEK-LFCLNFTI 133 house mouse
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap