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    Trim16 tripartite motif-containing 16 [ Mus musculus (house mouse) ]

    Gene ID: 94092, updated on 12-May-2024

    Summary

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    Official Symbol
    Trim16provided by MGI
    Official Full Name
    tripartite motif-containing 16provided by MGI
    Primary source
    MGI:MGI:2137356
    See related
    Ensembl:ENSMUSG00000047821 AllianceGenome:MGI:2137356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EBBP; 9130006M08Rik
    Summary
    Predicted to enable DNA binding activity; NACHT domain binding activity; and interleukin-1 binding activity. Located in cytoplasm. Is expressed in genitourinary system. Orthologous to several human genes including TRIM16 (tripartite motif containing 16). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in colon adult (RPKM 13.4), lung adult (RPKM 10.4) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B2; 11 38.75 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62711034..62733774)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62820198..62842948)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 286 Neighboring gene zinc finger protein 286, opposite strand Neighboring gene predicted gene, 24151 Neighboring gene STARR-seq mESC enhancer starr_29718 Neighboring gene F-box and WD-40 domain protein 10 Neighboring gene STARR-seq mESC enhancer starr_29719 Neighboring gene STARR-positive B cell enhancer ABC_E1826 Neighboring gene trans-golgi network vesicle protein 23B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The E3 Ligase TRIM16 Is a Key Suppressor of Pathological Cardiac Hypertrophy. Liu J, et al. Circ Res, 2022 May 13. PMID 35437018
    2. Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1. Wang L, et al. Cell Metab, 2021 Jul 6. PMID 34146477
    3. TRIM16 protects from OGD/R-induced oxidative stress in cultured hippocampal neurons by enhancing Nrf2/ARE antioxidant signaling via downregulation of Keap1. Ren X, et al. Exp Cell Res, 2020 Jun 1. PMID 32251645
    4. Heterozygous loss of keratinocyte TRIM16 expression increases melanocytic cell lesions and lymph node metastasis. Sutton SK, et al. J Cancer Res Clin Oncol, 2019 Sep. PMID 31342168, Free PMC Article
    5. TRIM16 exerts protective function on myocardial ischemia/reperfusion injury through reducing pyroptosis and inflammation via NLRP3 signaling. Shi M, et al. Biochem Biophys Res Commun, 2022 Dec 3. PMID 36208489

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRIM16 exerts protective function on myocardial ischemia/reperfusion injury through reducing pyroptosis and inflammation via NLRP3 signaling.
      Title: TRIM16 exerts protective function on myocardial ischemia/reperfusion injury through reducing pyroptosis and inflammation via NLRP3 signaling.
    2. The E3 Ligase TRIM16 Is a Key Suppressor of Pathological Cardiac Hypertrophy.
      Title: The E3 Ligase TRIM16 Is a Key Suppressor of Pathological Cardiac Hypertrophy.
    3. Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1.
      Title: Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1.
    4. TRIM16 protects from OGD/R-induced oxidative stress in cultured hippocampal neurons by enhancing Nrf2/ARE antioxidant signaling via downregulation of Keap1.
      Title: TRIM16 protects from OGD/R-induced oxidative stress in cultured hippocampal neurons by enhancing Nrf2/ARE antioxidant signaling via downregulation of Keap1.
    5. TRIM16 expression in keratinocytes is involved in cross talk between keratinocytes and melanocytes, and has a role in melanoma tumorigenesis.
      Title: Heterozygous loss of keratinocyte TRIM16 expression increases melanocytic cell lesions and lymph node metastasis.
    6. we demonstrate that genetic variation in Trim16 leads to its strain-dependent expression, which alters susceptibility to bleomycin-induced pulmonary fibrosis in mice.
      Title: Positional cloning reveals strain-dependent expression of Trim16 to alter susceptibility to bleomycin-induced pulmonary fibrosis in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NACHT domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-1 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 16
    Names
    E3 ubiquitin-protein ligase TRIM16
    estrogen-responsive B box protein
    tripartite motif protein 16
    NP_444399.2
    XP_006534643.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053169.2 → NP_444399.2  tripartite motif-containing protein 16

      See identical proteins and their annotated locations for NP_444399.2

      Status: VALIDATED

      Source sequence(s)
      AK053139, AK087112, BB033733
      Consensus CDS
      CCDS24832.1
      UniProtKB/Swiss-Prot
      Q7TPY6, Q8C332, Q8C6V0, Q99PP9
      UniProtKB/TrEMBL
      Q5SVT2
      Related
      ENSMUSP00000055542.6, ENSMUST00000055006.12
      Conserved Domains (2) summary
      pfam00643
      Location:117 → 157
      zf-B_box; B-box zinc finger
      cd12890
      Location:357 → 538
      SPRY_PRY_TRIM16; PRY/SPRY domain in tripartite motif-containing protein 16 (TRIM16)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      62711034..62733774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534580.5 → XP_006534643.1  tripartite motif-containing protein 16 isoform X1

      UniProtKB/Swiss-Prot
      Q7TPY6, Q8C332, Q8C6V0, Q99PP9
      Related
      ENSMUSP00000104343.2, ENSMUST00000108703.2
      Conserved Domains (4) summary
      pfam05483
      Location:87 → 275
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      cd12890
      Location:270 → 451
      SPRY_PRY_TRIM16; PRY/SPRY domain in tripartite motif-containing protein 16 (TRIM16)
      cd19769
      Location:33 → 78
      Bbox2_TRIM16-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM16, TRIM29, TRIM47 and similar proteins
      cl00034
      Location:1 → 26
      Bbox_SF; B-box-type zinc finger superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99PP9.2 GenPept UniProtKB/Swiss-Prot:Q99PP9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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