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    SRSF11 serine and arginine rich splicing factor 11 [ Homo sapiens (human) ]

    Gene ID: 9295, updated on 5-May-2024

    Summary

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    Official Symbol
    SRSF11provided by HGNC
    Official Full Name
    serine and arginine rich splicing factor 11provided by HGNC
    Primary source
    HGNC:HGNC:10782
    See related
    Ensembl:ENSG00000116754 MIM:602010; AllianceGenome:HGNC:10782
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p54; NET2; SFRS11; dJ677H15.2
    Summary
    This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.[provided by RefSeq, Sep 2010]
    Expression
    Ubiquitous expression in bone marrow (RPKM 46.2), skin (RPKM 32.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1p31.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (70205696..70253052)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (70084212..70131570)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (70671379..70718735)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 7 Neighboring gene NANOG hESC enhancer GRCh37_chr1:70503542-70504181 Neighboring gene LRRC7 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:70534982-70535190 Neighboring gene Sharpr-MPRA regulatory region 9273 Neighboring gene NANOG hESC enhancer GRCh37_chr1:70606447-70606948 Neighboring gene Sharpr-MPRA regulatory region 3760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:70626481-70626982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1186 Neighboring gene leucine rich repeat containing 40 Neighboring gene RNA, 7SL, cytoplasmic 242, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:70686957-70687502 Neighboring gene MPRA-validated peak281 silencer Neighboring gene ankyrin repeat domain 13C Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:70818812-70820011 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:70820190-70821107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1193 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:70826052-70826245 Neighboring gene ANKRD13C divergent transcript Neighboring gene long intergenic non-protein coding RNA 3102

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Regulation of gene expression programmes by serine-arginine rich splicing factors. Änkö ML. Semin Cell Dev Biol, 2014 Aug. PMID 24657192
    2. Microtubule interfering agents and KSP inhibitors induce the phosphorylation of the nuclear protein p54(nrb), an event linked to G2/M arrest. Casado P, et al. J Proteomics, 2009 Jan 30. PMID 18832053
    3. Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components. Chaudhary N, et al. Proc Natl Acad Sci U S A, 1991 Sep 15. PMID 1896467, Free PMC Article
    4. METTL3-mediated downregulation of splicing factor SRSF11 is associated with carcinogenesis and poor survival of cancer patients. Oh J, et al. Eur Rev Med Pharmacol Sci, 2023 Mar. PMID 37013774
    5. Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer. Pan YJ, et al. Clin Transl Med, 2022 Nov. PMID 36394206, Free PMC Article

    See all (108) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. METTL3-mediated downregulation of splicing factor SRSF11 is associated with carcinogenesis and poor survival of cancer patients.
      Title: METTL3-mediated downregulation of splicing factor SRSF11 is associated with carcinogenesis and poor survival of cancer patients.
    2. Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer.
      Title: Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer.
    3. Regulation of gene expression programmes by serine-arginine rich splicing factors.
      Title: Regulation of gene expression programmes by serine-arginine rich splicing factors.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    5. The G2/M arrest induced by MIAs is required for p54(nrb) phosphorylation. CDK activity is required for MIA-induced phosphorylation of p54(nrb).
      Title: Microtubule interfering agents and KSP inhibitors induce the phosphorylation of the nuclear protein p54(nrb), an event linked to G2/M arrest.
    6. SRp54 interacts with a purine-rich element tau in exon 10 and antagonizes Tra2beta, an SR-domain-containing protein that enhances exon 10 inclusion.
      Title: SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ18226, DKFZp686M13204

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/arginine-rich splicing factor 11
    Names
    SR splicing factor 11
    arginine-rich 54 kDa nuclear protein
    splicing factor p54
    splicing factor, arginine/serine-rich 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190987.3 → NP_001177916.1  serine/arginine-rich splicing factor 11 isoform 2

      See identical proteins and their annotated locations for NP_001177916.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses alternate splice sites in the 3' coding region and 5' UTR, compared to variant 1, and encodes an isoform (2) that is one aa shorter than isoform 1. Variants 2 and 5 encode the same protein (isoform 2).
      Source sequence(s)
      AI002238, AL832279, BC022815, BC040436, BF680379, BG494115, CN294419
      Consensus CDS
      CCDS53332.1
      UniProtKB/Swiss-Prot
      Q05519
      Related
      ENSP00000359989.1, ENST00000370951.5
      Conserved Domains (1) summary
      cd12518
      Location:34 → 113
      RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

    2. NM_001350605.2 → NP_001337534.1  serine/arginine-rich splicing factor 11 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL832279, BF680379, BG494115, CN294419, DA157431, DC415520, M74002
      Consensus CDS
      CCDS647.1
      UniProtKB/Swiss-Prot
      Q05519, Q5T758, Q8IWE6
      Related
      ENSP00000359987.2, ENST00000370949.2
      Conserved Domains (1) summary
      cd12518
      Location:34 → 113
      RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

    3. NM_001350606.2 → NP_001337535.1  serine/arginine-rich splicing factor 11 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL832279, BC022815, BF680379, BG494115, CB996573, CN294419, M74002
      Consensus CDS
      CCDS647.1
      UniProtKB/Swiss-Prot
      Q05519, Q5T758, Q8IWE6
      Conserved Domains (1) summary
      cd12518
      Location:34 → 113
      RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

    4. NM_001350607.2 → NP_001337536.1  serine/arginine-rich splicing factor 11 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL832279, BC022815, BC040436, BF680379, BG494115, CN294419, M74002
      Consensus CDS
      CCDS53332.1
      Conserved Domains (1) summary
      cd12518
      Location:34 → 113
      RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

    5. NM_001350608.2 → NP_001337537.1  serine/arginine-rich splicing factor 11 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL832279, BC022815, BF680379, BG494115, CN294419, CX869063, M74002
      Consensus CDS
      CCDS90976.1
      UniProtKB/TrEMBL
      Q5T760
      Related
      ENSP00000378568.3, ENST00000395136.7
      Conserved Domains (1) summary
      cd12518
      Location:34 → 113
      RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

    6. NM_001350609.2 → NP_001337538.1  serine/arginine-rich splicing factor 11 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL832279, BC022815, BF680379, BG494115, BG612368, CB996573, CN294419, CX869063, M74002
      Conserved Domains (1) summary
      cd12518
      Location:34 → 113
      RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

    7. NM_001350610.2 → NP_001337539.1  serine/arginine-rich splicing factor 11 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL353771, BF680379, BG494115, BM716576, BP290987, CA417788, CN294419, CX869063, DA157431, DA581964, DC415520
      UniProtKB/TrEMBL
      Q6MZM2

    8. NM_001350611.2 → NP_001337540.1  serine/arginine-rich splicing factor 11 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, BP290987, CA417788, CN294419, CX869063, DA157431, DA581964, DC415520

    9. NM_001350612.2 → NP_001337541.1  serine/arginine-rich splicing factor 11 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, CA417788, CN294419, DA157431, DA581964, DC415520
      UniProtKB/TrEMBL
      Q6MZM2

    10. NM_001350613.2 → NP_001337542.1  serine/arginine-rich splicing factor 11 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, CA417788, CN294419, DA157431, DA581964, DC415520
      UniProtKB/TrEMBL
      Q6MZM2

    11. NM_001350614.2 → NP_001337543.1  serine/arginine-rich splicing factor 11 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, BP290987, CA417788, CN294419, DA157431, DA581964, DC415520
      UniProtKB/TrEMBL
      Q6MZM2

    12. NM_001350615.2 → NP_001337544.1  serine/arginine-rich splicing factor 11 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, BP290987, CA417788, CN294419, CX869063, DA157431, DA581964, DC415520
      UniProtKB/TrEMBL
      Q6MZM2

    13. NM_001350616.2 → NP_001337545.1  serine/arginine-rich splicing factor 11 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, BP290987, CA417788, CN294419, DA157431, DA581964, DC415520
      UniProtKB/TrEMBL
      Q6MZM2

    14. NM_001394402.1 → NP_001381331.1  serine/arginine-rich splicing factor 11 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL353771
      Conserved Domains (1) summary
      smart00360
      Location:34 → 118
      RRM; RNA recognition motif

    15. NM_001394403.1 → NP_001381332.1  serine/arginine-rich splicing factor 11 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL353771
      Conserved Domains (1) summary
      smart00360
      Location:34 → 118
      RRM; RNA recognition motif

    16. NM_001394404.1 → NP_001381333.1  serine/arginine-rich splicing factor 11 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL353771
      Consensus CDS
      CCDS90976.1
      UniProtKB/TrEMBL
      Q5T760
      Conserved Domains (1) summary
      cd12518
      Location:34 → 113
      RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

    17. NM_001394405.1 → NP_001381334.1  serine/arginine-rich splicing factor 11 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL353771
      Conserved Domains (1) summary
      cd12518
      Location:34 → 113
      RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

    18. NM_001394406.1 → NP_001381335.1  serine/arginine-rich splicing factor 11 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL353771
      Consensus CDS
      CCDS647.1
      UniProtKB/Swiss-Prot
      Q05519, Q5T758, Q8IWE6
      Conserved Domains (1) summary
      cd12518
      Location:34 → 113
      RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

    19. NM_001394407.1 → NP_001381336.1  serine/arginine-rich splicing factor 11 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL353771
      Consensus CDS
      CCDS53332.1
      Conserved Domains (1) summary
      cd12518
      Location:34 → 113
      RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

    20. NM_001394408.1 → NP_001381337.1  serine/arginine-rich splicing factor 11 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL353771
      Consensus CDS
      CCDS53332.1
      Conserved Domains (1) summary
      cd12518
      Location:34 → 113
      RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

    21. NM_004768.5 → NP_004759.1  serine/arginine-rich splicing factor 11 isoform 1

      See identical proteins and their annotated locations for NP_004759.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 3, and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AI002238, AL832279, BC022815, BF680379, BG494115, CN294419, M74002
      Consensus CDS
      CCDS647.1
      UniProtKB/Swiss-Prot
      Q05519, Q5T758, Q8IWE6
      Related
      ENSP00000359988.3, ENST00000370950.7
      Conserved Domains (1) summary
      cd12518
      Location:34 → 113
      RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

    RNA

    1. NR_146810.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AI002238, AL832279, BF680379, BG494115, BP290987, CD687855, CN294419, DA157431, DC415520, M74002

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      70205696..70253052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434514.1 → XP_047290470.1  serine/arginine-rich splicing factor 11 isoform X1

      UniProtKB/TrEMBL
      Q5T760

    2. XM_047434518.1 → XP_047290474.1  serine/arginine-rich splicing factor 11 isoform X2

    3. XM_047434523.1 → XP_047290479.1  serine/arginine-rich splicing factor 11 isoform X3

      UniProtKB/Swiss-Prot
      Q05519, Q5T758, Q8IWE6

    4. XM_047434524.1 → XP_047290480.1  serine/arginine-rich splicing factor 11 isoform X4

    5. XM_047434516.1 → XP_047290472.1  serine/arginine-rich splicing factor 11 isoform X1

      UniProtKB/TrEMBL
      Q5T760

    6. XM_047434517.1 → XP_047290473.1  serine/arginine-rich splicing factor 11 isoform X1

      UniProtKB/TrEMBL
      Q5T760

    7. XM_047434522.1 → XP_047290478.1  serine/arginine-rich splicing factor 11 isoform X2

    8. XM_047434541.1 → XP_047290497.1  serine/arginine-rich splicing factor 11 isoform X7

    9. XM_047434536.1 → XP_047290492.1  serine/arginine-rich splicing factor 11 isoform X6

      UniProtKB/TrEMBL
      Q5T757

    10. XM_024450906.2 → XP_024306674.1  serine/arginine-rich splicing factor 11 isoform X5

      UniProtKB/TrEMBL
      Q6N079

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      70084212..70131570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339634.1 → XP_054195609.1  serine/arginine-rich splicing factor 11 isoform X1

      UniProtKB/TrEMBL
      Q5T760

    2. XM_054339637.1 → XP_054195612.1  serine/arginine-rich splicing factor 11 isoform X2

    3. XM_054339639.1 → XP_054195614.1  serine/arginine-rich splicing factor 11 isoform X3

      UniProtKB/Swiss-Prot
      Q05519, Q5T758, Q8IWE6

    4. XM_054339640.1 → XP_054195615.1  serine/arginine-rich splicing factor 11 isoform X4

    5. XM_054339635.1 → XP_054195610.1  serine/arginine-rich splicing factor 11 isoform X1

      UniProtKB/TrEMBL
      Q5T760

    6. XM_054339636.1 → XP_054195611.1  serine/arginine-rich splicing factor 11 isoform X1

      UniProtKB/TrEMBL
      Q5T760

    7. XM_054339638.1 → XP_054195613.1  serine/arginine-rich splicing factor 11 isoform X2

    8. XM_054339645.1 → XP_054195620.1  serine/arginine-rich splicing factor 11 isoform X7

    9. XM_054339644.1 → XP_054195619.1  serine/arginine-rich splicing factor 11 isoform X6

      UniProtKB/TrEMBL
      Q5T757

    10. XM_054339642.1 → XP_054195617.1  serine/arginine-rich splicing factor 11 isoform X5

    11. XM_054339641.1 → XP_054195616.1  serine/arginine-rich splicing factor 11 isoform X5

    12. XM_054339643.1 → XP_054195618.1  serine/arginine-rich splicing factor 11 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05519.1 GenPept UniProtKB/Swiss-Prot:Q05519

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