ANP32A acidic nuclear phosphoprotein 32 family member A [Homo sapiens (human)] - Gene

Summary

Official Symbol: ANP32Aprovided by HGNC
Official Full Name: acidic nuclear phosphoprotein 32 family member Aprovided by HGNC
Primary source: HGNC:HGNC:13233
See related: Ensembl:ENSG00000140350 MIM:600832; AllianceGenome:HGNC:13233
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LANP; MAPM; PP32; HPPCn; PHAP1; PHAPI; I1PP2A; C15orf1
Summary: Enables RNA binding activity. Involved in nucleocytoplasmic transport. Located in endoplasmic reticulum; nucleus; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lymph node (RPKM 45.8), bone marrow (RPKM 40.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q23

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (68778535..68820895, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (66601108..66643452, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (69070874..69113234, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glaucoma-Associated CDR1 Peptide Promotes RGC Survival in Retinal Explants through Molecular Interaction with Acidic Leucine Rich Nuclear Phosphoprotein 32A (ANP32A).
Title: Glaucoma-Associated CDR1 Peptide Promotes RGC Survival in Retinal Explants through Molecular Interaction with Acidic Leucine Rich Nuclear Phosphoprotein 32A (ANP32A).
Hypoxia and Wnt signaling inversely regulate expression of chondroprotective molecule ANP32A in articular cartilage.
Title: Hypoxia and Wnt signaling inversely regulate expression of chondroprotective molecule ANP32A in articular cartilage.
Avian Influenza A Virus Polymerase Can Utilize Human ANP32 Proteins To Support cRNA but Not vRNA Synthesis.
Title: Avian Influenza A Virus Polymerase Can Utilize Human ANP32 Proteins To Support cRNA but Not vRNA Synthesis.
[Silenced ANP32A inhibits the growth, invasion and migration of colorectal cancer in vitro via the inactivation of AKT pathway].
Title: [Silenced ANP32A inhibits the growth, invasion and migration of colorectal cancer in vitro via the inactivation of AKT pathway].
AIMP1 promotes multiple myeloma malignancy through interacting with ANP32A to mediate histone H3 acetylation.
Title: AIMP1 promotes multiple myeloma malignancy through interacting with ANP32A to mediate histone H3 acetylation.
KPNA6 is a Cofactor of ANP32A/B in Supporting Influenza Virus Polymerase Activity.
Title: KPNA6 is a Cofactor of ANP32A/B in Supporting Influenza Virus Polymerase Activity.
ANP32A promotes the proliferation, migration and invasion of hepatocellular carcinoma by modulating the HMGA1/STAT3 pathway.
Title: ANP32A promotes the proliferation, migration and invasion of hepatocellular carcinoma by modulating the HMGA1/STAT3 pathway.
Host ANP32A mediates the assembly of the influenza virus replicase.
Title: Host ANP32A mediates the assembly of the influenza virus replicase.
Molecular basis of host-adaptation interactions between influenza virus polymerase PB2 subunit and ANP32A.
Title: Molecular basis of host-adaptation interactions between influenza virus polymerase PB2 subunit and ANP32A.
Avian ANP32A proteins harbor an additional 33 amino acids compared to human ANP32A proteins, which are crucial for their ability to support the avian-origin influenza virus polymerase. Species differences in ANP32A can restrict the host range of influenza virus.
Title: Elucidating the Interactions between Influenza Virus Polymerase and Host Factor ANP32A.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Rev	rev	The interaction of Rev with ANP32A is decreased by the presence of RRE	PubMed
	rev	HIV-1 Rev interacting protein, acidic (leucine-rich) nuclear phosphoprotein 32 family, member A (ANP32A), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:483159

RH46906 (e-PCR)
- UniSTS:91225

D15S1277 (e-PCR)
- UniSTS:45411

RH70903 (e-PCR)
- UniSTS:88981

ANP32C__4314 (e-PCR)
- UniSTS:463541

SGC30863 (e-PCR)
- UniSTS:42937

NoName (e-PCR)
- UniSTS:480453

D15S1181 (e-PCR)
- UniSTS:23541

D9S2077 (e-PCR)
- UniSTS:65022

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in nucleocytoplasmic transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleocytoplasmic transport	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleocytoplasmic transport	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: acidic leucine-rich nuclear phosphoprotein 32 family member A

Names: acidic (leucine-rich) nuclear phosphoprotein 32 family, member A; acidic nuclear phosphoprotein pp32; cerebellar leucine rich acidic nuclear protein; epididymis secretory sperm binding protein; hepatopoietin Cn; inhibitor-1 of protein phosphatase-2A; leucine-rich acidic nuclear protein; mapmodulin; potent heat-stable protein phosphatase 2A inhibitor I1PP2A; putative HLA-DR-associated protein I; putative human HLA class II associated protein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.