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    ZNF135 zinc finger protein 135 [ Homo sapiens (human) ]

    Gene ID: 7694, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF135provided by HGNC
    Official Full Name
    zinc finger protein 135provided by HGNC
    Primary source
    HGNC:HGNC:12919
    See related
    Ensembl:ENSG00000176293 MIM:604077; AllianceGenome:HGNC:12919
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    pT3; ZNF61; pHZ-17; ZNF78L1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cytoskeleton organization and regulation of cell morphogenesis. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in ovary (RPKM 3.4), endometrium (RPKM 3.3) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    19q13.43
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58059239..58069755)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61156060..61166554)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58570607..58581123)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 1 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1 pseudogene 2 Neighboring gene HNRNPDL pseudogene 4 Neighboring gene RNA, 7SL, cytoplasmic 526, pseudogene Neighboring gene zinc finger and SCAN domain containing 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Chromosomal localization of four human zinc finger cDNAs. Huebner K, et al. Hum Genet, 1993 Apr. PMID 8478004
    2. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. Tommerup N, et al. Genomics, 1995 May 20. PMID 7557990
    3. Characterization and mapping of human genes encoding zinc finger proteins. Bray P, et al. Proc Natl Acad Sci U S A, 1991 Nov 1. PMID 1946370, Free PMC Article
    4. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. Lichter P, et al. Genomics, 1992 Aug. PMID 1505991
    5. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. Bai SW, et al. BMC Biol, 2011 Aug 11. PMID 21834987, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 135
    Names
    zinc finger protein 135 (clone pHZ-17)
    zinc finger protein 61
    zinc finger protein 78-like 1 (pT3)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164527.1 → NP_001157999.1  zinc finger protein 135 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. It encodes isoform 3 which has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK094202, CN367970, DA232862, DB117846
      UniProtKB/TrEMBL
      Q8N9M3
      Conserved Domains (2) summary
      smart00349
      Location:26 → 85
      KRAB; krueppel associated box
      pfam01352
      Location:26 → 65
      KRAB; KRAB box

    2. NM_001164529.1 → NP_001158001.1  zinc finger protein 135 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 4 which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK094202, AK098011, AL833637, BX647775, DB117846, DB304820
      UniProtKB/Swiss-Prot
      P52742
      UniProtKB/TrEMBL
      Q8N9M3
      Conserved Domains (2) summary
      smart00349
      Location:26 → 85
      KRAB; krueppel associated box
      pfam01352
      Location:26 → 65
      KRAB; KRAB box

    3. NM_001164530.1 → NP_001158002.1  zinc finger protein 135 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two alternate segments in the coding region, one of which results in a frameshift, compared to variant 1. The encoded isoform 5 is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK094202, AK098011, AK297226, BX647775, DB304820
      Consensus CDS
      CCDS54330.1
      UniProtKB/Swiss-Prot
      P52742
      UniProtKB/TrEMBL
      B4DLZ7, Q8N9M3
      Related
      ENSP00000369437.4, ENST00000359978.10
      Conserved Domains (6) summary
      smart00349
      Location:26 → 85
      KRAB; krueppel associated box
      COG5048
      Location:148 → 389
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:228 → 248
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:226 → 248
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:26 → 65
      KRAB; KRAB box
      pfam13465
      Location:352 → 377
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001289401.2 → NP_001276330.1  zinc finger protein 135 isoform 6

      See identical proteins and their annotated locations for NP_001276330.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 3' coding region, and includes an alternate exon that results in a distinct 5' UTR and uses of an alternate start codon, compared to variant 1. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK094202, AL833637, BC046434, BM993886, BX647775
      Consensus CDS
      CCDS74471.1
      UniProtKB/Swiss-Prot
      B4DHH9, E9PEV2, F5GYY9, I3L0B3, P52742, Q5U5L3, Q8N1I7
      Related
      ENSP00000321406.5, ENST00000313434.10
      Conserved Domains (6) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:240 → 641
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:440 → 460
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:214 → 236
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:480 → 505
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001289402.2 → NP_001276331.1  zinc finger protein 135 isoform 7

      See identical proteins and their annotated locations for NP_001276331.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) uses an alternate in-frame splice site in the 3' coding region, and includes an alternate exon that results in a distinct 5' UTR and uses of a downstream start codon, compared to variant 1. The encoded isoform (7) is shorter, compared to isoform 1.
      Source sequence(s)
      AK094202, AL833637, BC046434, BM993886, BX647775
      Consensus CDS
      CCDS74472.1
      UniProtKB/TrEMBL
      Q8N9M3
      Related
      ENSP00000427691.1, ENST00000506786.1
      Conserved Domains (3) summary
      COG5048
      Location:198 → 599
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:398 → 418
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:438 → 463
      zf-H2C2_2; Zinc-finger double domain

    6. NM_003436.4 → NP_003427.3  zinc finger protein 135 isoform 2

      See identical proteins and their annotated locations for NP_003427.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon that results in a distinct 5' UTR and causes translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK094202, AK098011, AK295110, BX647775, DB304820
      Consensus CDS
      CCDS12970.2
      UniProtKB/Swiss-Prot
      P52742
      UniProtKB/TrEMBL
      Q8N9M3
      Related
      ENSP00000422074.1, ENST00000511556.5
      Conserved Domains (6) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:252 → 653
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:452 → 472
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:226 → 248
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain

    7. NM_007134.1 → NP_009065.1  zinc finger protein 135 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK094202, AK098011, BX647775, DB117846, DB304820
      Consensus CDS
      CCDS54329.1
      UniProtKB/Swiss-Prot
      P52742
      UniProtKB/TrEMBL
      Q8N9M3
      Related
      ENSP00000441410.1, ENST00000401053.8
      Conserved Domains (6) summary
      smart00349
      Location:26 → 85
      KRAB; krueppel associated box
      COG5048
      Location:264 → 665
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:464 → 484
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:238 → 260
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:26 → 65
      KRAB; KRAB box
      pfam13465
      Location:504 → 529
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      58059239..58069755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006723362.5 → XP_006723425.1  zinc finger protein 135 isoform X1

      See identical proteins and their annotated locations for XP_006723425.1

      UniProtKB/Swiss-Prot
      P52742
      Conserved Domains (6) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:252 → 653
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:452 → 472
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:226 → 248
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain

    2. XM_047439362.1 → XP_047295318.1  zinc finger protein 135 isoform X3

      UniProtKB/Swiss-Prot
      B4DHH9, E9PEV2, F5GYY9, I3L0B3, P52742, Q5U5L3, Q8N1I7

    3. XM_005259211.2 → XP_005259268.1  zinc finger protein 135 isoform X2

      Conserved Domains (6) summary
      smart00349
      Location:26 → 85
      KRAB; krueppel associated box
      COG5048
      Location:252 → 653
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:452 → 472
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:226 → 248
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:26 → 65
      KRAB; KRAB box
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain

    4. XM_006723363.4 → XP_006723426.1  zinc finger protein 135 isoform X1

      See identical proteins and their annotated locations for XP_006723426.1

      UniProtKB/Swiss-Prot
      P52742
      Conserved Domains (6) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:252 → 653
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:452 → 472
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:226 → 248
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain

    5. XM_047439363.1 → XP_047295319.1  zinc finger protein 135 isoform X3

      UniProtKB/Swiss-Prot
      B4DHH9, E9PEV2, F5GYY9, I3L0B3, P52742, Q5U5L3, Q8N1I7

    6. XM_047439364.1 → XP_047295320.1  zinc finger protein 135 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      61156060..61166554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322003.1 → XP_054177978.1  zinc finger protein 135 isoform X1

    2. XM_054322006.1 → XP_054177981.1  zinc finger protein 135 isoform X3

    3. XM_054322005.1 → XP_054177980.1  zinc finger protein 135 isoform X2

    4. XM_054322007.1 → XP_054177982.1  zinc finger protein 135 isoform X3

    5. XM_054322004.1 → XP_054177979.1  zinc finger protein 135 isoform X1

    6. XM_054322008.1 → XP_054177983.1  zinc finger protein 135 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52742.3 GenPept UniProtKB/Swiss-Prot:P52742

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