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    Tars2 threonyl-tRNA synthetase 2, mitochondrial (putative) [ Mus musculus (house mouse) ]

    Gene ID: 71807, updated on 12-May-2024

    Summary

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    Official Symbol
    Tars2provided by MGI
    Official Full Name
    threonyl-tRNA synthetase 2, mitochondrial (putative)provided by MGI
    Primary source
    MGI:MGI:1919057
    See related
    Ensembl:ENSMUSG00000028107 AllianceGenome:MGI:1919057
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    thrRS; Tarsl1; 2610024N01Rik
    Summary
    Predicted to enable aminoacyl-tRNA editing activity; protein homodimerization activity; and threonine-tRNA ligase activity. Predicted to be involved in threonyl-tRNA aminoacylation. Predicted to act upstream of or within translation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 21. Orthologous to human TARS2 (threonyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.8), large intestine adult (RPKM 6.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 F2.1; 3 40.93 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95647286..95663677, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95739974..95756365, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene myeloid cell leukemia sequence 1 Neighboring gene ADAMTS-like 4 Neighboring gene STARR-seq mESC enhancer starr_08394 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:95511513-95511622 Neighboring gene microRNA 7014 Neighboring gene extracellular matrix protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E2087 Neighboring gene regulation of nuclear pre-mRNA domain containing 2 Neighboring gene predicted gene, 26361 Neighboring gene lactate dehydrogenase A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Knockdown of mitochondrial threonyl-tRNA synthetase 2 inhibits lung adenocarcinoma cell proliferation and induces apoptosis. Tian H, et al. Bioengineered, 2022 Mar. PMID 35184682, Free PMC Article
    2. Molecular dynamics investigation into substrate binding and identity of the catalytic base in the mechanism of Threonyl-tRNA synthetase. Bushnell EA, et al. J Phys Chem B, 2012 May 3. PMID 22482363
    3. Threonyl-tRNA synthetase. Freist W, et al. Biol Chem Hoppe Seyler, 1995 Apr. PMID 7626230
    4. Evolution of aminoacyl-tRNA synthetases--analysis of unique domain architectures and phylogenetic trees reveals a complex history of horizontal gene transfer events. Wolf YI, et al. Genome Res, 1999 Aug. PMID 10447505
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of mitochondrial threonyl-tRNA synthetase 2 inhibits lung adenocarcinoma cell proliferation and induces apoptosis.
      Title: Knockdown of mitochondrial threonyl-tRNA synthetase 2 inhibits lung adenocarcinoma cell proliferation and induces apoptosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables threonine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables threonine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in threonyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    threonine--tRNA ligase, mitochondrial
    Names
    threonyl-tRNA synthetase, mitochondrial
    threonyl-tRNA synthetase-like 1
    NP_001157089.1
    NP_001157090.1
    NP_001157091.1
    NP_001343894.1
    NP_001343895.1
    NP_001343896.1
    NP_082207.2
    XP_011238538.1
    XP_030108688.1
    XP_030108689.1
    XP_036019229.1
    XP_036019230.1
    XP_036019231.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163617.1 → NP_001157089.1  threonine--tRNA ligase, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001157089.1

      Status: VALIDATED

      Source sequence(s)
      AC093317, AK142685, BG277177, CO042173
      Consensus CDS
      CCDS50996.1
      UniProtKB/TrEMBL
      Q922A3
      Related
      ENSMUSP00000073946.7, ENSMUST00000074339.13
      Conserved Domains (5) summary
      cd01667
      Location:66 → 127
      TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
      PLN02908
      Location:27 → 689
      PLN02908; threonyl-tRNA synthetase
      smart00863
      Location:234 → 281
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
      cd00771
      Location:305 → 592
      ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00860
      Location:592 → 683
      ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

    2. NM_001163618.1 → NP_001157090.1  threonine--tRNA ligase, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC093317, AK142685, BG087111, CO042173
      Consensus CDS
      CCDS50994.1
      UniProtKB/TrEMBL
      E9Q7H6
      Related
      ENSMUSP00000130269.2, ENSMUST00000163530.8
      Conserved Domains (5) summary
      cd01667
      Location:66 → 127
      TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
      PLN02908
      Location:27 → 634
      PLN02908; threonyl-tRNA synthetase
      smart00863
      Location:153 → 200
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
      cd00771
      Location:224 → 537
      ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00860
      Location:537 → 628
      ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

    3. NM_001163619.1 → NP_001157091.1  threonine--tRNA ligase, mitochondrial isoform 4

      See identical proteins and their annotated locations for NP_001157091.1

      Status: VALIDATED

      Source sequence(s)
      AC093317, AK164589
      Consensus CDS
      CCDS50995.1
      UniProtKB/TrEMBL
      Q3TP97
      Related
      ENSMUSP00000096456.5, ENSMUST00000098857.9
      Conserved Domains (3) summary
      cd01667
      Location:66 → 127
      TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
      smart00863
      Location:234 → 281
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
      cl00268
      Location:305 → 417
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

    4. NM_001356965.1 → NP_001343894.1  threonine--tRNA ligase, mitochondrial isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC093317, CO042173, MG954306
      Conserved Domains (1) summary
      PLN02908
      Location:3 → 476
      PLN02908; threonyl-tRNA synthetase

    5. NM_001356966.1 → NP_001343895.1  threonine--tRNA ligase, mitochondrial isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC093317, CO042173, MG954306
      Conserved Domains (1) summary
      PLN02908
      Location:3 → 476
      PLN02908; threonyl-tRNA synthetase

    6. NM_001356967.1 → NP_001343896.1  threonine--tRNA ligase, mitochondrial isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC093317, CO042173, MG954306
      Conserved Domains (1) summary
      PLN02908
      Location:3 → 476
      PLN02908; threonyl-tRNA synthetase

    7. NM_027931.3 → NP_082207.2  threonine--tRNA ligase, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_082207.2

      Status: VALIDATED

      Source sequence(s)
      AC093317, AK142685, CO042173
      Consensus CDS
      CCDS38548.1
      UniProtKB/Swiss-Prot
      B2RW19, Q3UQ84, Q9D0D6
      Related
      ENSMUSP00000029752.9, ENSMUST00000029752.15
      Conserved Domains (1) summary
      PLN02908
      Location:27 → 715
      PLN02908; threonyl-tRNA synthetase

    RNA

    1. NR_151588.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC093317, CO042173, MG954306
      Related
      ENSMUST00000199464.5

    2. NR_151589.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC093317, AK164825, CO042173, MG954306
      Related
      ENSMUST00000196077.5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95647286..95663677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252828.1 → XP_030108688.1  threonine--tRNA ligase, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      B2RW19, Q3UQ84, Q9D0D6
      Conserved Domains (1) summary
      PLN02908
      Location:27 → 715
      PLN02908; threonyl-tRNA synthetase

    2. XM_011240236.2 → XP_011238538.1  threonine--tRNA ligase, mitochondrial isoform X2

      Conserved Domains (1) summary
      PLN02908
      Location:27 → 666
      PLN02908; threonyl-tRNA synthetase

    3. XM_036163336.1 → XP_036019229.1  threonine--tRNA ligase, mitochondrial isoform X3

      Conserved Domains (1) summary
      PLN02908
      Location:27 → 585
      PLN02908; threonyl-tRNA synthetase

    4. XM_036163337.1 → XP_036019230.1  threonine--tRNA ligase, mitochondrial isoform X4

      Conserved Domains (1) summary
      PLN02908
      Location:3 → 476
      PLN02908; threonyl-tRNA synthetase

    5. XM_036163338.1 → XP_036019231.1  threonine--tRNA ligase, mitochondrial isoform X4

      Conserved Domains (1) summary
      PLN02908
      Location:3 → 476
      PLN02908; threonyl-tRNA synthetase

    6. XM_030252829.1 → XP_030108689.1  threonine--tRNA ligase, mitochondrial isoform X4

      Conserved Domains (1) summary
      PLN02908
      Location:3 → 476
      PLN02908; threonyl-tRNA synthetase

    RNA

    1. XR_004941399.1 RNA Sequence

    2. XR_004941400.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UQ84.1 GenPept UniProtKB/Swiss-Prot:Q3UQ84

    Gene LinkOut

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