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    Glod4 glyoxalase domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 67201, updated on 9-May-2024

    Summary

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    Official Symbol
    Glod4provided by MGI
    Official Full Name
    glyoxalase domain containing 4provided by MGI
    Primary source
    MGI:MGI:1914451
    See related
    Ensembl:ENSMUSG00000017286 AllianceGenome:MGI:1914451
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700082G03Rik; 2700085E05Rik
    Summary
    Located in mitochondrion. Orthologous to human GLOD4 (glyoxalase domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 10.6), bladder adult (RPKM 8.2) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B5; 11 45.92 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (76111221..76134525, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (76220395..76243699, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8426 Neighboring gene STARR-seq mESC enhancer starr_30015 Neighboring gene gem nuclear organelle associated protein 4 Neighboring gene diazepam binding inhibitor-like 5 Neighboring gene STARR-positive B cell enhancer ABC_E7019 Neighboring gene mitochondrial rRNA methyltransferase 3 Neighboring gene nucleoredoxin Neighboring gene STARR-seq mESC enhancer starr_30020 Neighboring gene STARR-seq mESC enhancer starr_30022 Neighboring gene STARR-seq mESC enhancer starr_30023 Neighboring gene STARR-seq mESC enhancer starr_30026

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease. Cozzolino F, et al. Hum Mol Genet, 2021 Jun 17. PMID 33601422
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: Vps53

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    glyoxalase domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362901.1 → NP_001349830.1  glyoxalase domain-containing protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL591129
      Consensus CDS
      CCDS88193.1
      UniProtKB/TrEMBL
      E9Q197
      Related
      ENSMUSP00000131788.2, ENSMUST00000170710.8
      Conserved Domains (2) summary
      cd16357
      Location:121 → 236
      GLOD4_C; C-terminal domain of human glyoxalase domain-containing protein 4 and similar proteins
      cl14632
      Location:12 → 111
      VOC; vicinal oxygen chelate (VOC) family

    2. NM_026029.3 → NP_080305.2  glyoxalase domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_080305.2

      Status: VALIDATED

      Source sequence(s)
      AI450701, AL591129, BC061012, BY122171, CF950671
      Consensus CDS
      CCDS25063.1
      UniProtKB/Swiss-Prot
      Q3UUS8, Q9CPV4, Q9CY26, Q9D9F5
      UniProtKB/TrEMBL
      E9Q197
      Related
      ENSMUSP00000017430.6, ENSMUST00000017430.12
      Conserved Domains (3) summary
      cd08358
      Location:4 → 130
      Glo_EDI_BRP_like_21; This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases
      cd06587
      Location:141 → 255
      Glo_EDI_BRP_like; This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins
      PLN02300
      Location:4 → 264
      PLN02300; lactoylglutathione lyase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      76111221..76134525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CPV4.1 GenPept UniProtKB/Swiss-Prot:Q9CPV4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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