ctbp1 C-terminal binding protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ctbp1provided by ZNC
Official Full Name: C-terminal binding protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-010130-1
See related: Ensembl:ENSDARG00000057007 AllianceGenome:ZFIN:ZDB-GENE-010130-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fi43a11
Summary: Predicted to enable NAD binding activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and transcription corepressor activity. Acts upstream of or within retinoic acid receptor signaling pathway. Predicted to be located in nucleus. Orthologous to human CTBP1 (C-terminal binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 14

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (21820087..21846181)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (21522842..21548936)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In zebrafish hair cells exogenous Ribeye B-domain and CtBP1 localize to the basal ends of synaptic ribbons.
Title: Characterization of Ribeye subunits in zebrafish hair cells reveals that exogenous Ribeye B-domain and CtBP1 localize to the basal ends of synaptic ribbons.
Tel orchestrates endothelial sprouting by binding to the generic co-repressor, CtBP
Title: Control of endothelial sprouting by a Tel-CtBP complex.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fi48a11.x1 (e-PCR)
- UniSTS:204616

fi43a11.x1 (e-PCR)
- UniSTS:197519

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retinoic acid receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: C-terminal-binding protein 1; C-terminal binding protein 1

XP_005173190.1

EC 1.1.1.-

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131714.3 → NP_571789.3 C-terminal-binding protein 1

Status: VALIDATED

Source sequence(s)

BX324205

Related

ENSDARP00000107990.1, ENSDART00000122739.3

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

21820087..21846181

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005173133.2 → XP_005173190.1 C-terminal binding protein 1 isoform X1

UniProtKB/TrEMBL

A0A8M2BKF1, Q7ZU55

Conserved Domains (2) summary

COG1052
Location:100 → 409

LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]

cd05299
Location:83 → 401

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor