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    MIIP migration and invasion inhibitory protein [ Homo sapiens (human) ]

    Gene ID: 60672, updated on 5-Mar-2024

    Summary

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    Official Symbol
    MIIPprovided by HGNC
    Official Full Name
    migration and invasion inhibitory proteinprovided by HGNC
    Primary source
    HGNC:HGNC:25715
    See related
    Ensembl:ENSG00000116691 MIM:608772; AllianceGenome:HGNC:25715
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IIP45
    Summary
    This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011]
    Expression
    Ubiquitous expression in bone marrow (RPKM 14.3), testis (RPKM 8.7) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1p36.22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (12019498..12032045)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (11563622..11576189)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (12079555..12092102)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11994483-11995406 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:11998825-12000024 Neighboring gene Sharpr-MPRA regulatory region 8260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12005168-12005843 Neighboring gene procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:12023296-12023497 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:12026474-12026974 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:12026975-12027475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 279 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 183 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12060855-12061784 Neighboring gene mitofusin 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:12065587-12065864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 185 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12067964-12068629 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12068630-12069294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 186 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:12079342-12080212 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12080213-12081083 Neighboring gene CRISPRi-validated cis-regulatory element chr1.1957 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 188 Neighboring gene microRNA 6729 Neighboring gene RNA, 7SL, cytoplasmic 649, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 191 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 193 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 195 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 281 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 196 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 197 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:12122803-12123035 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 198 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 199 Neighboring gene TNF receptor superfamily member 8 Neighboring gene RNA, U6 small nuclear 777, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MIIP inhibits the growth of prostate cancer via interaction with PP1α and negative modulation of AKT signaling. Yan G, et al. Cell Commun Signal, 2019 May 15. PMID 31092266, Free PMC Article
    2. MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer. Sun Y, et al. J Pathol, 2017 Jan. PMID 27741356, Free PMC Article
    3. MIIP expression predicts outcomes of surgically resected esophageal squamous cell carcinomas. Wen J, et al. Tumour Biol, 2016 Aug. PMID 26825982
    4. Inhibition of gliomagenesis and attenuation of mitotic transition by MIIP. Ji P, et al. Oncogene, 2010 Jun 17. PMID 20418911
    5. Definition of a functional single nucleotide polymorphism in the cell migration inhibitory gene MIIP that affects the risk of breast cancer. Song F, et al. Cancer Res, 2010 Feb 1. PMID 20103646

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MIIP inhibits clear cell renal cell carcinoma proliferation and angiogenesis via negative modulation of the HIF-2alpha-CYR61 axis.
      Title: MIIP inhibits clear cell renal cell carcinoma proliferation and angiogenesis via negative modulation of the HIF-2α-CYR61 axis.
    2. MIIP inhibits malignant progression of hepatocellular carcinoma through regulating AKT.
      Title: MIIP inhibits malignant progression of hepatocellular carcinoma through regulating AKT.
    3. MIIP suppresses oncogenic AKT-mTOR signaling in prostate cancer by facilitating PP1-mediated AKT dephosphorylation.
      Title: MIIP inhibits the growth of prostate cancer via interaction with PP1α and negative modulation of AKT signaling.
    4. MIIP was significantly decreased and IGFBP2 was significantly increased in breast cancer tissues versus para cancerous.
      Title: Upregulation of MIIP regulates human breast cancer proliferation, invasion and migration by mediated by IGFBP2.
    5. Dysregulated miR-646 and MIIP expression was correlated with advanced tumor stage, lymphatic invasion, metastasis and shorter overall survival in Pancreatic cancer patients.
      Title: MiRNA-646-mediated reciprocal repression between HIF-1α and MIIP contributes to tumorigenesis of pancreatic cancer.
    6. Data show that protein kinase C epsilon (PKCepsilon) phosphorylates migration and invasion inhibitory protein (MIIP) at Ser303 and promotes its binding to RelA/p65, facilitating colorectal cancer metastasis.
      Title: PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation.
    7. MIIP may function as a tumor suppressor gene for endometrial carcinoma. MIIP attenuates Rac1 signaling through a protein interaction network, and loss of this regulator may contribute to EC metastasis.
      Title: MIIP remodels Rac1-mediated cytoskeleton structure in suppression of endometrial cancer metastasis.
    8. MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer.
      Title: MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer.
    9. MIIP expression in esophageal squamous-cell carcinoma tissues was increased significantly in comparison with the paired paracancerous normal epithelia and was associated with cell differentiation. Patients with low MIIP expression had improved overall and disease-free survival. MIIP expression was an independent prognostic factor in ESCC OS and DFS.
      Title: MIIP expression predicts outcomes of surgically resected esophageal squamous cell carcinomas.
    10. MIIP attenuates mitotic transition and increases mitotic catastrophe, thereby inhibiting glioma development and progression.
      Title: Inhibition of gliomagenesis and attenuation of mitotic transition by MIIP.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef-mediated downregulation of HLA (MHCI) may be affected by/inhibited by' MIIP as demonstrated by siRNA genome-wide screen [in HeLa cells) PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12438, FLJ38609

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    migration and invasion-inhibitory protein
    Names
    IGFBP2-binding protein
    invasion-inhibitory protein 45

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030022.2 RefSeqGene

      Range
      5257..17804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_021933.4 → NP_068752.2  migration and invasion-inhibitory protein

      See identical proteins and their annotated locations for NP_068752.2

      Status: REVIEWED

      Source sequence(s)
      FJ618905
      Consensus CDS
      CCDS143.1
      UniProtKB/Swiss-Prot
      C0KL22, Q5JXC2, Q96HU6, Q9H839, Q9HA00
      Related
      ENSP00000235332.4, ENST00000235332.6
      Conserved Domains (1) summary
      pfam15734
      Location:66 → 378
      MIIP; Migration and invasion-inhibitory

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      12019498..12032045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541895.2 → XP_011540197.1  migration and invasion-inhibitory protein isoform X1

      See identical proteins and their annotated locations for XP_011540197.1

      UniProtKB/Swiss-Prot
      C0KL22, Q5JXC2, Q96HU6, Q9H839, Q9HA00
      Conserved Domains (1) summary
      pfam15734
      Location:66 → 378
      MIIP; Migration and invasion-inhibitory

    2. XM_011541896.2 → XP_011540198.1  migration and invasion-inhibitory protein isoform X1

      See identical proteins and their annotated locations for XP_011540198.1

      UniProtKB/Swiss-Prot
      C0KL22, Q5JXC2, Q96HU6, Q9H839, Q9HA00
      Conserved Domains (1) summary
      pfam15734
      Location:66 → 378
      MIIP; Migration and invasion-inhibitory

    3. XM_005263487.5 → XP_005263544.1  migration and invasion-inhibitory protein isoform X2

      Conserved Domains (1) summary
      pfam15734
      Location:66 → 366
      MIIP; Migration and invasion-inhibitory

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      11563622..11576189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338078.1 → XP_054194053.1  migration and invasion-inhibitory protein isoform X2

    2. XM_054338077.1 → XP_054194052.1  migration and invasion-inhibitory protein isoform X1

    3. XM_054338076.1 → XP_054194051.1  migration and invasion-inhibitory protein isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001025374.1: Suppressed sequence

      Description
      NM_001025374.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JXC2.3 GenPept UniProtKB/Swiss-Prot:Q5JXC2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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