sptb spectrin, beta, erythrocytic [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sptbprovided by ZNC
Official Full Name: spectrin, beta, erythrocyticprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000906-1
See related: Ensembl:ENSDARG00000030490 AllianceGenome:ZFIN:ZDB-GENE-000906-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fa09g12; wu:fa09g12
Summary: Predicted to enable actin filament binding activity. Acts upstream of or within embryonic hemopoiesis and erythrocyte development. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of spectrin. Predicted to be active in several cellular components, including cell junction; cortical actin cytoskeleton; and plasma membrane. Is expressed in intermediate cell mass of mesoderm. Human ortholog(s) of this gene implicated in hereditary spherocytosis and hereditary spherocytosis type 2. Orthologous to human SPTB (spectrin beta, erythrocytic). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (38566659..38601051)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (38619074..38651427)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin filament capping	IEA Inferred from Electronic Annotation more info
involved_in actin filament capping	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte development	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
is_active_in cell junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of spectrin	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: spectrin beta chain, erythrocytic; spectrin beta chain, erythrocyte

Names: b-spectrin; beta-spectrin; riesling; ris

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131525.1 → NP_571600.1 spectrin beta chain, erythrocytic

See identical proteins and their annotated locations for NP_571600.1

Status: PROVISIONAL

Source sequence(s)

AF262336

UniProtKB/TrEMBL

Q9DGM6

Related

ENSDARP00000040626.5, ENSDART00000040627.6

Conserved Domains (5) summary

cd00014
Location:182 → 285

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:538 → 749

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:2204 → 2309

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:2202 → 2309

PH; PH domain

pfam00435
Location:430 → 532

Spectrin; Spectrin repeat

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

38566659..38601051

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005158850.3 → XP_005158907.1 spectrin beta chain, erythrocyte isoform X2

See identical proteins and their annotated locations for XP_005158907.1

UniProtKB/TrEMBL

A0A8M2B5U4, F1QQE5

Related

ENSDARP00000113965.1, ENSDART00000145147.4

Conserved Domains (5) summary

cd00014
Location:182 → 285

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:538 → 749

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:2204 → 2309

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:2202 → 2309

PH; PH domain

pfam00435
Location:430 → 532

Spectrin; Spectrin repeat
XM_005158851.4 → XP_005158908.1 spectrin beta chain, erythrocyte isoform X2

See identical proteins and their annotated locations for XP_005158908.1

UniProtKB/TrEMBL

A0A8M2B5U4, F1QQE5

Conserved Domains (5) summary

cd00014
Location:182 → 285

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:538 → 749

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:2204 → 2309

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:2202 → 2309

PH; PH domain

pfam00435
Location:430 → 532

Spectrin; Spectrin repeat
XM_005158849.4 → XP_005158906.1 spectrin beta chain, erythrocyte isoform X1

UniProtKB/TrEMBL

A0A8M2B5B6

Conserved Domains (5) summary

cd00014
Location:306 → 409

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:662 → 873

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:2328 → 2433

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:2326 → 2433

PH; PH domain

pfam00435
Location:554 → 656

Spectrin; Spectrin repeat