Copb2 COPI coat complex subunit beta 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Copb2provided by MGI
Official Full Name: COPI coat complex subunit beta 2provided by MGI
Primary source: MGI:MGI:1354962
See related: Ensembl:ENSMUSG00000032458 AllianceGenome:MGI:1354962
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable protein kinase C binding activity. Acts upstream of or within toxin transport. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; liver lobe; nervous system; olfactory epithelium; and retina. Used to study microcephaly. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 19. Orthologous to human COPB2 (COPI coat complex subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 73.6), CNS E11.5 (RPKM 43.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E3.3; 9 51.4 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (98445784..98470428)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (98563731..98588375)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

beta-COP Suppresses the Surface Expression of the TREK2.
Title: β-COP Suppresses the Surface Expression of the TREK2.
COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay.
Title: COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intra-Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intra-Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of COPI vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
part_of COPI vesicle coat	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info	PubMed
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of membrane coat	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: coatomer subunit beta'

Names: beta'-COP; beta'-coat protein; coatomer protein complex, subunit beta 2 (beta prime); p102

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015827.2 → NP_056642.1 coatomer subunit beta'

See identical proteins and their annotated locations for NP_056642.1

Status: PROVISIONAL

Source sequence(s)

AK088064

Consensus CDS

CCDS40734.1

UniProtKB/Swiss-Prot

O55029, Q3U5Z9

Related

ENSMUSP00000035033.6, ENSMUST00000035033.7

Conserved Domains (3) summary

cd00200
Location:8 → 297

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:103 → 140

7WD40; WD40 repeat [structural motif]

pfam04053
Location:319 → 763

Coatomer_WDAD; Coatomer WD associated region