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    NFYB nuclear transcription factor Y subunit beta [ Homo sapiens (human) ]

    Gene ID: 4801, updated on 31-Mar-2024

    Summary

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    Official Symbol
    NFYBprovided by HGNC
    Official Full Name
    nuclear transcription factor Y subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:7805
    See related
    Ensembl:ENSG00000120837 MIM:189904; AllianceGenome:HGNC:7805
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HAP3; CBF-A; CBF-B; NF-YB
    Summary
    The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in prostate (RPKM 10.4), endometrium (RPKM 9.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    12q23.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (104117086..104138210, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (104078781..104099908, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (104510864..104531988, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene glycosyltransferase 8 domain containing 2 Neighboring gene phosphoglycerate mutase 1 (brain) pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23711 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4784 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:104458005-104458174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4786 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23722 Neighboring gene host cell factor C2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23731 Neighboring gene RNA, 5S ribosomal pseudogene 370 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:104530547-104531140 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:104531141-104531732 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4789 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4790 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23735 Neighboring gene uncharacterized LOC105369947 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23741 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23744 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23747 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23754 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23756 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23757 Neighboring gene long intergenic non-protein coding RNA 2385

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Over-expression of NFYB affects stromal cells reprogramming and predicts worse survival in gastric cancer patients. Lu T, et al. Aging (Albany NY), 2022 Sep 22. PMID 36152055, Free PMC Article
    2. NFYB potentiates STK33 activation to promote cisplatin resistance in diffuse large B-cell lymphoma. Feng L, et al. Leuk Res, 2021 Dec. PMID 34536775
    3. NF-Y is associated with the histone acetyltransferases GCN5 and P/CAF. Currie RA. J Biol Chem, 1998 Jan 16. PMID 9430679
    4. Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y. Pise-Masison CA, et al. Mol Cell Biol, 1997 Mar. PMID 9032250, Free PMC Article
    5. Human thymidine kinase CCAAT-binding protein is NF-Y, whose A subunit expression is serum-dependent in human IMR-90 diploid fibroblasts. Chang ZF, et al. J Biol Chem, 1994 Jul 8. PMID 8027044

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Unraveling the intricacies of glioblastoma progression and recurrence: insights into the role of NFYB and oxidative phosphorylation at the single-cell level.
      Title: Unraveling the intricacies of glioblastoma progression and recurrence: insights into the role of NFYB and oxidative phosphorylation at the single-cell level.
    2. NFYB increases chemosensitivity in glioblastoma by promoting HDAC5-mediated transcriptional inhibition of SHMT2.
      Title: NFYB increases chemosensitivity in glioblastoma by promoting HDAC5-mediated transcriptional inhibition of SHMT2.
    3. Long Non-coding RNA H19 Recruits NFYB to Activate MBTD1 and Regulate Doxorubicin Resistance in Lymphoma Cells.
      Title: Long Non-coding RNA H19 Recruits NFYB to Activate MBTD1 and Regulate Doxorubicin Resistance in Lymphoma Cells.
    4. Over-expression of NFYB affects stromal cells reprogramming and predicts worse survival in gastric cancer patients.
      Title: Over-expression of NFYB affects stromal cells reprogramming and predicts worse survival in gastric cancer patients.
    5. NFYB potentiates STK33 activation to promote cisplatin resistance in diffuse large B-cell lymphoma.
      Title: NFYB potentiates STK33 activation to promote cisplatin resistance in diffuse large B-cell lymphoma.
    6. The nuclear transcription factor Y subunit beta (NFYB)-E2F transcription factor 1 (E2F1) pathway displays a crucial role in the chemoresistance ofoxaliplatin-resistant colorectal cancer (OR-CRC) by inducing the expression and activation of checkpoint kinase 1 (CHK1), suggesting a possible therapeutic target for oxaliplatin resistance in CRC.
      Title: NFYB-induced high expression of E2F1 contributes to oxaliplatin resistance in colorectal cancer via the enhancement of CHK1 signaling.
    7. Data indicate that specific cancer-driving nodes are generally under NF-YA/B control.
      Title: NF-Y activates genes of metabolic pathways altered in cancer cells.
    8. Presence of NF-Y transcription factor plays a pivotal role in transcriptional regulation of ID genes in development.
      Title: Epigenetic role of CCAAT box-binding transcription factor NF-Y on ID gene family in human embryonic carcinoma cells.
    9. NF-YB transcription factor was identified as a novel direct E2F1 target.
      Title: E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program.
    10. The NF-Y complex is asymmetric, with NF-YB binding approximately 15 bp downstream from the CCAAT motif.
      Title: NF-Y coassociates with FOS at promoters, enhancers, repetitive elements, and inactive chromatin regions, and is stereo-positioned with growth-controlling transcription factors.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of selenium concentrations.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CCAAT-binding factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCAAT-binding factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CCAAT-binding factor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-DNA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear transcription factor Y subunit beta
    Names
    CAAT box DNA-binding protein subunit B
    CCAAT-binding transcription factor subunit A
    Transcription factor NF-Y, B subunit
    nuclear transcription factor Y subunit B
    nuclear transcription factor Y, beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414518.1 → NP_001401447.1  nuclear transcription factor Y subunit beta isoform a

      Status: REVIEWED

      Source sequence(s)
      AC089983
      UniProtKB/TrEMBL
      F8VSL3
      Related
      ENSP00000448250.2, ENST00000551446.6

    2. NM_001414519.1 → NP_001401448.1  nuclear transcription factor Y subunit beta isoform a

      Status: REVIEWED

      Source sequence(s)
      AC089983
      UniProtKB/TrEMBL
      F8VSL3

    3. NM_001414520.1 → NP_001401449.1  nuclear transcription factor Y subunit beta isoform b

      Status: REVIEWED

      Source sequence(s)
      AC089983
      UniProtKB/Swiss-Prot
      A8K7B9, P25208, Q96IY8

    4. NM_001414521.1 → NP_001401450.1  nuclear transcription factor Y subunit beta isoform b

      Status: REVIEWED

      Source sequence(s)
      AC089983
      UniProtKB/Swiss-Prot
      A8K7B9, P25208, Q96IY8
      Related
      ENSP00000447486.1, ENST00000551727.5

    5. NM_001414522.1 → NP_001401451.1  nuclear transcription factor Y subunit beta isoform c

      Status: REVIEWED

      Source sequence(s)
      AC089983

    6. NM_001414523.1 → NP_001401452.1  nuclear transcription factor Y subunit beta isoform d

      Status: REVIEWED

      Source sequence(s)
      AC089983

    7. NM_001414524.1 → NP_001401453.1  nuclear transcription factor Y subunit beta isoform d

      Status: REVIEWED

      Source sequence(s)
      AC089983

    8. NM_001414525.1 → NP_001401454.1  nuclear transcription factor Y subunit beta isoform d

      Status: REVIEWED

      Source sequence(s)
      AC089983

    9. NM_001414526.1 → NP_001401455.1  nuclear transcription factor Y subunit beta isoform d

      Status: REVIEWED

      Source sequence(s)
      AC089983

    10. NM_001414527.1 → NP_001401456.1  nuclear transcription factor Y subunit beta isoform e

      Status: REVIEWED

      Source sequence(s)
      AC089983

    11. NM_001414528.1 → NP_001401457.1  nuclear transcription factor Y subunit beta isoform f

      Status: REVIEWED

      Source sequence(s)
      AC089983

    12. NM_001414529.1 → NP_001401458.1  nuclear transcription factor Y subunit beta isoform f

      Status: REVIEWED

      Source sequence(s)
      AC089983

    13. NM_001414530.1 → NP_001401459.1  nuclear transcription factor Y subunit beta isoform g

      Status: REVIEWED

      Source sequence(s)
      AC089983

    14. NM_001414531.1 → NP_001401460.1  nuclear transcription factor Y subunit beta isoform h

      Status: REVIEWED

      Source sequence(s)
      AC089983

    15. NM_001414532.1 → NP_001401461.1  nuclear transcription factor Y subunit beta isoform h

      Status: REVIEWED

      Source sequence(s)
      AC089983

    16. NM_006166.4 → NP_006157.1  nuclear transcription factor Y subunit beta isoform b

      See identical proteins and their annotated locations for NP_006157.1

      Status: REVIEWED

      Source sequence(s)
      AA479300, AL042186, AU151875, AW576189, BC005316, BF032637, BG776259, BQ420877, CD678671
      Consensus CDS
      CCDS9098.1
      UniProtKB/Swiss-Prot
      A8K7B9, P25208, Q96IY8
      Related
      ENSP00000240055.3, ENST00000240055.8
      Conserved Domains (1) summary
      pfam00808
      Location:57 → 122
      CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone

    RNA

    1. NR_182773.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089983

    2. NR_182774.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089983

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      104117086..104138210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005268910.5 → XP_005268967.1  nuclear transcription factor Y subunit beta isoform X1

      See identical proteins and their annotated locations for XP_005268967.1

      UniProtKB/TrEMBL
      F8VSL3
      Conserved Domains (1) summary
      pfam00808
      Location:58 → 123
      CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone

    2. XM_047428880.1 → XP_047284836.1  nuclear transcription factor Y subunit beta isoform X2

      UniProtKB/Swiss-Prot
      A8K7B9, P25208, Q96IY8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      104078781..104099908 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372113.1 → XP_054228088.1  nuclear transcription factor Y subunit beta isoform X1

      UniProtKB/TrEMBL
      F8VSL3

    2. XM_054372114.1 → XP_054228089.1  nuclear transcription factor Y subunit beta isoform X2

      UniProtKB/Swiss-Prot
      A8K7B9, P25208, Q96IY8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25208.2 GenPept UniProtKB/Swiss-Prot:P25208

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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