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    NR2F1-AS1 NR2F1 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 441094, updated on 15-Jan-2024

    Summary

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    Official Symbol
    NR2F1-AS1provided by HGNC
    Official Full Name
    NR2F1 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:48622
    See related
    Ensembl:ENSG00000237187 AllianceGenome:HGNC:48622
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in brain (RPKM 3.7), gall bladder (RPKM 2.2) and 20 other tissues See more
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    Genomic context

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    See NR2F1-AS1 in Genome Data Viewer
    Location:
    5q15
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (93409356..93585589, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (93893440..94069652, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (92745062..92917026, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379083 Neighboring gene VISTA enhancer hs1170 Neighboring gene NANOG hESC enhancer GRCh37_chr5:92582002-92582507 Neighboring gene VISTA enhancer hs1060 Neighboring gene VISTA enhancer hs1172 Neighboring gene DNA polymerase delta 2, accessory subunit pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:92694967-92696166 Neighboring gene Sharpr-MPRA regulatory region 8230 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:92792425-92792926 Neighboring gene VISTA enhancer hs546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:92840906-92841406 Neighboring gene uncharacterized LOC124901026 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16175 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22788 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16176 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16177 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:92931735-92932535 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:92932536-92933335 Neighboring gene uncharacterized LOC124901027 Neighboring gene NANOG hESC enhancer GRCh37_chr5:92935096-92935597 Neighboring gene Sharpr-MPRA regulatory region 13970 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:92953840-92954648 Neighboring gene nuclear receptor subfamily 2 group F member 1 Neighboring gene microRNA 2277 Neighboring gene ARB2 cotranscriptional regulator A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. NR2F1-AS1: A Functional Long Noncoding RNA in Tumorigenesis. Hu J, et al. Curr Med Chem, 2023. PMID 36644870
    2. A review on the role of NR2F1-AS1 in the development of cancer. Ghafouri-Fard S, et al. Pathol Res Pract, 2022 Dec. PMID 36410172
    3. Hypoxia-induced long noncoding RNA NR2F1-AS1 maintains pancreatic cancer proliferation, migration, and invasion by activating the NR2F1/AKT/mTOR axis. Liu Y, et al. Cell Death Dis, 2022 Mar 14. PMID 35283481, Free PMC Article
    4. LncRNA nuclear receptor subfamily 2 group F member 1 antisense RNA 1 (NR2F1-AS1) aggravates nucleus pulposus cell apoptosis and extracellular matrix degradation. Du L, et al. Bioengineered, 2022 Feb. PMID 35094651, Free PMC Article
    5. NR2F1-AS1 Acts as an Oncogene in Breast Cancer by Competitively Binding with miR-641. Zhong Y, et al. J Healthc Eng, 2022. PMID 35083026, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA NR2F1-AS1 as a potential biomarker for prognosis in cancer patients: meta and bioinformatics analysis.
      Title: LncRNA NR2F1-AS1 as a potential biomarker for prognosis in cancer patients: meta and bioinformatics analysis.
    2. Lnc NR2F1-AS1 Promotes Breast Cancer Metastasis by Targeting the MiR-25-3p/ZEB2 Axis.
      Title: Lnc NR2F1-AS1 Promotes Breast Cancer Metastasis by Targeting the MiR-25-3p/ZEB2 Axis.
    3. NR2F1-AS1: A Functional Long Noncoding RNA in Tumorigenesis.
      Title: NR2F1-AS1: A Functional Long Noncoding RNA in Tumorigenesis.
    4. A review on the role of NR2F1-AS1 in the development of cancer.
      Title: A review on the role of NR2F1-AS1 in the development of cancer.
    5. Hypoxia-induced long noncoding RNA NR2F1-AS1 maintains pancreatic cancer proliferation, migration, and invasion by activating the NR2F1/AKT/mTOR axis.
      Title: Hypoxia-induced long noncoding RNA NR2F1-AS1 maintains pancreatic cancer proliferation, migration, and invasion by activating the NR2F1/AKT/mTOR axis.
    6. The EMT-induced lncRNA NR2F1-AS1 positively modulates NR2F1 expression and drives gastric cancer via miR-29a-3p/VAMP7 axis.
      Title: The EMT-induced lncRNA NR2F1-AS1 positively modulates NR2F1 expression and drives gastric cancer via miR-29a-3p/VAMP7 axis.
    7. LncRNA nuclear receptor subfamily 2 group F member 1 antisense RNA 1 (NR2F1-AS1) aggravates nucleus pulposus cell apoptosis and extracellular matrix degradation.
      Title: LncRNA nuclear receptor subfamily 2 group F member 1 antisense RNA 1 (NR2F1-AS1) aggravates nucleus pulposus cell apoptosis and extracellular matrix degradation.
    8. STAT3 activates the transcription of lncRNA NR2F1-AS1 to promote the progression of melanoma via regulating the miR-493-5p/GOLM1 axis.
      Title: STAT3 activates the transcription of lncRNA NR2F1-AS1 to promote the progression of melanoma via regulating the miR-493-5p/GOLM1 axis.
    9. Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and DeltaNp63.
      Title: Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63.
    10. LncRNA NR2F1-AS1 Regulates miR-371a-3p/TOB1 Axis to Suppress Proliferation of Colorectal Cancer Cells.
      Title: LncRNA NR2F1-AS1 Regulates miR-371a-3p/TOB1 Axis to Suppress Proliferation of Colorectal Cancer Cells.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Clone Names

    • FLJ42709, DKFZp686H18199

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_021490.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC106818, AC114961
      Related
      ENST00000661182.1

    2. NR_021491.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818
      Related
      ENST00000665798.1

    3. NR_109818.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC106818, AC114961
      Related
      ENST00000504474.5

    4. NR_109819.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC106818, AC114961

    5. NR_109820.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818
      Related
      ENST00000671514.1

    6. NR_109821.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818, AC114961

    7. NR_109822.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818
      Related
      ENST00000510254.7

    8. NR_109823.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818
      Related
      ENST00000671432.1

    9. NR_109824.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818
      Related
      ENST00000653133.1

    10. NR_109825.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC012619, AC106818

    11. NR_186182.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC012619, AC106818
      Related
      ENST00000663096.1

    12. NR_186183.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC106818, AC114961

    13. NR_186184.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818
      Related
      ENST00000660787.1

    14. NR_186185.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818
      Related
      ENST00000661345.1

    15. NR_186186.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818, AC114961
      Related
      ENST00000656079.1

    16. NR_186187.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC012619, AC106818

    17. NR_186188.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818
      Related
      ENST00000671683.1

    18. NR_186189.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818
      Related
      ENST00000659983.1

    19. NR_186190.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818, AC114961
      Related
      ENST00000664017.1

    20. NR_186191.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818, AC114961

    21. NR_186192.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818
      Related
      ENST00000654431.1

    22. NR_186193.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818, AC114961

    23. NR_186194.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818

    24. NR_186195.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818, AC114961

    25. NR_186196.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818

    26. NR_186197.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818
      Related
      ENST00000655613.1

    27. NR_186198.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818, AC114961

    28. NR_186199.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818
      Related
      ENST00000658662.1

    29. NR_186200.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC012619, AC106818

    30. NR_186201.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC012619, AC106818

    31. NR_186202.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC106818, AC114961

    32. NR_186203.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC012619, AC106818

    33. NR_186204.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818
      Related
      ENST00000656921.1

    34. NR_186205.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818, AC114961

    35. NR_186206.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818
      Related
      ENST00000607797.5

    36. NR_186207.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818
      Related
      ENST00000666791.1

    37. NR_186209.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818, AC114961

    38. NR_186210.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC106818, AC114961

    39. NR_186211.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818

    40. NR_186212.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC106818, AC114961

    41. NR_186213.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818, AC114961

    42. NR_186214.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818

    43. NR_186215.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818, AC114961

    44. NR_186216.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818, AC114961
      Related
      ENST00000657648.1

    45. NR_186217.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818
      Related
      ENST00000661870.1

    46. NR_186218.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818
      Related
      ENST00000659381.1

    47. NR_186219.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818, AC114961

    48. NR_186220.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818

    49. NR_186221.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC106818
      Related
      ENST00000656155.1

    50. NR_186222.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008500, AC012619, AC106818

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      93409356..93585589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      93893440..94069652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_015369.1: Suppressed sequence

      Description
      NR_015369.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.