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    CUEDC1 CUE domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 404093, updated on 7-Apr-2024

    Summary

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    Official Symbol
    CUEDC1provided by HGNC
    Official Full Name
    CUE domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:31350
    See related
    Ensembl:ENSG00000180891 MIM:620552; AllianceGenome:HGNC:31350
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable ubiquitin binding activity. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in prostate (RPKM 6.5), brain (RPKM 6.5) and 25 other tissues See more
    Orthologs
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    Genomic context

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    Location:
    17q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (57861243..57955412, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (58734503..58828695, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (55938604..56032773, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 94 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55887988-55888874 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:55910113-55910624 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:55910625-55911135 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55911304-55911804 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55923593-55924200 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:55927391-55927900 Neighboring gene mitochondrial ribosomal protein S23 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55937722-55938572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55938573-55939422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55939423-55940272 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:55945275-55946474 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55951125-55951765 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55951766-55952407 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55953049-55953690 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55953691-55954331 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:55956376-55956928 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55958036-55958588 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55958589-55959141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55962626-55963126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55969929-55970670 Neighboring gene Sharpr-MPRA regulatory region 2303 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55977227-55977897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12452 Neighboring gene uncharacterized LOC107985065 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55991179-55991679 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:56004573-56005088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12454 Neighboring gene Sharpr-MPRA regulatory region 4150 Neighboring gene Sharpr-MPRA regulatory region 6256 Neighboring gene NANOG hESC enhancer GRCh37_chr17:56029838-56030339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8753 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:56043109-56043617 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:56046907-56047067 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8755 Neighboring gene uncharacterized LOC101929185 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12455 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12456 Neighboring gene vascular endothelial zinc finger 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12457 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:56082218-56083417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12459 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:56084242-56084960 Neighboring gene serine and arginine rich splicing factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. [Prognostic Significance of CUEDC1 in Patients with Acute Myeloid Leukemia (non-M(3))]. Zhuang WC, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2020 Oct. PMID 33067938
    2. CUEDC1 inhibits epithelial-mesenchymal transition via the TβRI/Smad signaling pathway and suppresses tumor progression in non-small cell lung cancer. Cui Y, et al. Aging (Albany NY), 2020 Oct 25. PMID 33099540, Free PMC Article
    3. CUEDC1 is a primary target of ERα essential for the growth of breast cancer cells. Lopes R, et al. Cancer Lett, 2018 Nov 1. PMID 30145202
    4. Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis. Baranzini SE, et al. Brain, 2010 Sep. PMID 20802204, Free PMC Article
    5. Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2. Lim SK, et al. Cancer Res, 2016 Nov 1. PMID 27578003

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CUEDC1 inhibits epithelial-mesenchymal transition via the TbetaRI/Smad signaling pathway and suppresses tumor progression in non-small cell lung cancer.
      Title: CUEDC1 inhibits epithelial-mesenchymal transition via the TβRI/Smad signaling pathway and suppresses tumor progression in non-small cell lung cancer.
    2. [Prognostic Significance of CUEDC1 in Patients with Acute Myeloid Leukemia (non-M3)].
      Title: [Prognostic Significance of CUEDC1 in Patients with Acute Myeloid Leukemia (non-M(3))].
    3. Data inidicate CUE domain containing 1 (CUEDC1) expression correlates positively with estrogen receptor alpha (ERalpha) in breast cancer, and suggest CUEDC1 is a functional target gene of ERalpha and is required for breast cancer cell proliferation.
      Title: CUEDC1 is a primary target of ERα essential for the growth of breast cancer cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20739, DKFZp547L163

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CUE domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271875.2 → NP_001258804.1  CUE domain-containing protein 1

      See identical proteins and their annotated locations for NP_001258804.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC015813, AC015845, AK000746, BC056882, BG475111, BU732837
      Consensus CDS
      CCDS11599.1
      UniProtKB/Swiss-Prot
      D3DTZ2, Q9NWD0, Q9NWM3
      Related
      ENSP00000462717.1, ENST00000577830.6
      Conserved Domains (1) summary
      cd14366
      Location:46 → 87
      CUE_CUED1; CUE domain found in CUE domain-containing protein 1 (CUED1) and similar proteins

    2. NM_001292025.2 → NP_001278954.1  CUE domain-containing protein 1

      See identical proteins and their annotated locations for NP_001278954.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC015845, AK000746, BC056882, BU732837, CR627470
      Consensus CDS
      CCDS11599.1
      UniProtKB/Swiss-Prot
      D3DTZ2, Q9NWD0, Q9NWM3
      Related
      ENSP00000353373.2, ENST00000360238.6
      Conserved Domains (1) summary
      cd14366
      Location:46 → 87
      CUE_CUED1; CUE domain found in CUE domain-containing protein 1 (CUED1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      57861243..57955412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024641.3 → XP_016880130.1  CUE domain-containing protein 1 isoform X2

    2. XM_047436060.1 → XP_047292016.1  CUE domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DTZ2, Q9NWD0, Q9NWM3

    3. XM_011524812.3 → XP_011523114.1  CUE domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      J3QLQ8
      Related
      ENSP00000463666.1, ENST00000577840.5

    RNA

    1. XR_934459.4 RNA Sequence

    2. XR_934460.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      58734503..58828695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316112.1 → XP_054172087.1  CUE domain-containing protein 1 isoform X2

    2. XM_054316111.1 → XP_054172086.1  CUE domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DTZ2, Q9NWD0, Q9NWM3

    3. XM_054316113.1 → XP_054172088.1  CUE domain-containing protein 1 isoform X3

    RNA

    1. XR_008484819.1 RNA Sequence

    2. XR_008484820.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NWM3.1 GenPept UniProtKB/Swiss-Prot:Q9NWM3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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