Igfbp1 insulin-like growth factor binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Igfbp1provided by RGD
Official Full Name: insulin-like growth factor binding protein 1provided by RGD
Primary source: RGD:2872
See related: Ensembl:ENSRNOG00000058780 AllianceGenome:RGD:2872
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IBP1; IGFBA; IGF-BP25
Summary: Predicted to enable insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in several processes, including insulin receptor signaling pathway; positive regulation of cell growth; and tissue regeneration. Located in extracellular space. Human ortholog(s) of this gene implicated in diabetic angiopathy. Orthologous to human IGFBP1 (insulin like growth factor binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 641.0) and Kidney (RPKM 149.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (86261277..86266344)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (82047415..82052482)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (87448716..87453783)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In simulated sleep apnea hypopnea syndrome, intermittent hypoxia in young rats does not cause physical growth retardation, but serum IGF-1 and IGFBP-3 levels decreased with the increase of hypoxia and decline of oxygen saturation.
Title: [Study on intermittent hypoxia in children sleep apnea hypopnea syndrome model and insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels in serum].
up-regulation of IGFBP-1 in oligodendrocytes in multiple sclerosis may serve two functions: (i) regulate IGF-1 actions, (ii) exert IGF-independent effects through its RGD sequence
Title: Insulin-like growth factor binding protein-1 activates integrin-mediated intracellular signaling and migration in oligodendrocytes.
Age-related oxidative stress underlies the upregulated JNK activation and IGFBP-1 expression.
Title: Regulation of insulin-like growth factor binding protein-1 expression during aging.
mRNA expression during the postnatal development of rat masseter muscle
Title: Changes in the mRNA expressions of insulin-like growth factors, their receptors, and binding proteins during the postnatal development of rat masseter muscle.
IGFBP-1 released during the early steps of liver tissue damage and repair may interact with liver cells and potentiate the sensitivity of IGF-I to mitogenic signals.
Title: Insulin-like growth factor (IGF)-binding protein-1 is highly induced during acute carbon tetrachloride liver injury and potentiates the IGF-I-stimulated activation of rat hepatic stellate cells.
IGFBP-1 and IGFBP-3 are present in phosphorylated form in fasted rat skin, which induced inhibition of collagen biosynthesis in cultured fibroblasts
Title: Expression of IGF-binding protein-1 phosphoisoforms in fasted rat skin and its role in regulation of collagen biosynthesis.
Activation of the mTOR pathway, without activation of its upstream regulator PI 3-kinase, reduces IGFBP1 expression.
Title: A temporal switch in the insulin-signalling pathway that regulates hepatic IGF-binding protein-1 gene expression.
Insulin regulation of insulin-like growth factor-binding protein-1 gene expression
Title: Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase activity.
Iron, radical oxygen species, and HIF-2 and -3 as well as prolyl hydroxylase pathways play important roles in mediating effects of hypoxia on IGFBP-1 gene expression in liver.
Title: Oxygen-dependent modulation of insulin-like growth factor binding protein biosynthesis in primary cultures of rat hepatocytes.
regulation of expression by insulin is impaired by presence of hydrogen peroxide
Title: Insulin regulation of hepatic insulin-like growth factor-binding protein-1 (IGFBP-1) gene expression and mammalian target of rapamycin (mTOR) signalling is impaired by the presence of hydrogen peroxide.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

RH125040 (e-PCR)
- UniSTS:161862

Igfbp1 (e-PCR), detects polymorphism
- UniSTS:516199

Igfbp1 (e-PCR), detects polymorphism
- UniSTS:143486

BF391491 (e-PCR)
- UniSTS:249792

RH132476 (e-PCR)
- UniSTS:215759

BG074389 (e-PCR), detects polymorphism
- UniSTS:526815

RH94537 (e-PCR)
- UniSTS:119785

RH94795 (e-PCR)
- UniSTS:120042

BI276188 (e-PCR)
- UniSTS:249835

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables insulin-like growth factor I binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor I binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor II binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor II binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in glucose metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in insulin receptor signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in phosphatidylinositol-mediated signaling	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cell growth	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to insulin	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in tissue regeneration	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: insulin-like growth factor-binding protein 1

Names: IBP-1; IGF-binding protein 1; IGFBP-1; placental protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013144.2 → NP_037276.1 insulin-like growth factor-binding protein 1 precursor

See identical proteins and their annotated locations for NP_037276.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

P21743

Related

ENSRNOP00000069247.1, ENSRNOT00000077177.2

Conserved Domains (2) summary

smart00121
Location:30 → 107

IB; Insulin growth factor-binding protein homologues

pfam00086
Location:189 → 264

Thyroglobulin_1; Thyroglobulin type-1 repeat