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    Zfp101 zinc finger protein 101 [ Mus musculus (house mouse) ]

    Gene ID: 22643, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp101provided by MGI
    Official Full Name
    zinc finger protein 101provided by MGI
    Primary source
    MGI:MGI:107547
    See related
    Ensembl:ENSMUSG00000055240 AllianceGenome:MGI:107547
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Is expressed in several structures, including early conceptus; genitourinary system; heart; hemolymphoid system gland; and liver. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 7.9), limb E14.5 (RPKM 6.4) and 12 other tissues See more
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    Genomic context

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    Location:
    17 B1; 17 17.98 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33599148..33613593, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33380174..33394637, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 955B Neighboring gene zinc finger protein 422, pseudogene Neighboring gene zinc finger protein 81 Neighboring gene STARR-positive B cell enhancer mm9_chr17:33495732-33496033 Neighboring gene actin-like 9 Neighboring gene NFIL3 like basic leucine zipper

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Human MD2 deficiency-an inborn error of immunity with pleiotropic features. Li Y, et al. J Allergy Clin Immunol, 2023 Mar. PMID 36462957
    2. A novel cDNA isolated from the mouse eye lens encoding a protein with zinc fingers and a KRAB domain. Brady JP, et al. DNA Seq, 1995. PMID 8777319
    3. Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5. Abe K, et al. Mamm Genome, 2004 Apr. PMID 15112104
    4. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
    5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Human MD2 deficiency-an inborn error of immunity with pleiotropic features.
      Title: Human MD2 deficiency-an inborn error of immunity with pleiotropic features.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 101

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414008.1 → NP_001400937.1  zinc finger protein 101 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT030734

    2. NM_001414009.1 → NP_001400938.1  zinc finger protein 101 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT030734

    3. NM_001414010.1 → NP_001400939.1  zinc finger protein 101 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT030734

    4. NM_001414011.1 → NP_001400940.1  zinc finger protein 101 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT030734

    5. NM_001414012.1 → NP_001400941.1  zinc finger protein 101 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT030734

    6. NM_009542.3 → NP_033568.2  zinc finger protein 101 isoform 1

      See identical proteins and their annotated locations for NP_033568.2

      Status: VALIDATED

      Source sequence(s)
      CT030734
      Consensus CDS
      CCDS37565.1
      UniProtKB/TrEMBL
      Q8BP18
      Related
      ENSMUSP00000132508.3, ENSMUST00000167107.10
      Conserved Domains (6) summary
      smart00349
      Location:10 → 50
      KRAB; krueppel associated box
      COG5048
      Location:190 → 612
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:388 → 408
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:10 → 49
      KRAB; KRAB box
      pfam06798
      Location:32 → 80
      PrkA; PrkA serine protein kinase C-terminal domain
      pfam13465
      Location:428 → 453
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      33599148..33613593 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246418.4 → XP_011244720.1  zinc finger protein 101 isoform X1

      Conserved Domains (3) summary
      COG5048
      Location:187 → 609
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:385 → 405
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 46
      KRAB; KRAB box
    Nucleotide Protein Strain
    Heading Accession and Version

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