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    Plcl2 phospholipase C-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 224860, updated on 8-May-2024

    Summary

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    Official Symbol
    Plcl2provided by MGI
    Official Full Name
    phospholipase C-like 2provided by MGI
    Primary source
    MGI:MGI:1352756
    See related
    Ensembl:ENSMUSG00000038910 AllianceGenome:MGI:1352756
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Plce2; PLC-L2; PRIP-2; mKIAA1092
    Summary
    Predicted to enable GABA receptor binding activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including B cell activation; gamma-aminobutyric acid signaling pathway; and negative regulation of B cell receptor signaling pathway. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human PLCL2 (phospholipase C like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cortex adult (RPKM 8.5), CNS E18 (RPKM 6.4) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 C; 17 25.86 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (50815893..50995522)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (50508865..50688494)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31015 Neighboring gene STARR-seq mESC enhancer starr_42795 Neighboring gene predicted gene, 30958 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:50609750-50609937 Neighboring gene STARR-positive B cell enhancer ABC_E8684 Neighboring gene predicted gene, 54010 Neighboring gene STARR-positive B cell enhancer ABC_E7543 Neighboring gene STARR-seq mESC enhancer starr_42797 Neighboring gene STARR-seq mESC enhancer starr_42798 Neighboring gene STARR-seq mESC enhancer starr_42799 Neighboring gene B-cell translocation gene 3 pseudogene Neighboring gene TBC1 domain family, member 5 Neighboring gene predicted gene, 41598

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phospholipase C-related but catalytically inactive protein acts as a positive regulator of insulin signalling in adipocytes. Gao J, et al. J Cell Sci, 2022 Jan 1. PMID 34859819
    2. Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice. Yamawaki Y, et al. Neurochem Int, 2019 Dec. PMID 31589911
    3. Genetic reduction of GABA(A) receptor gamma2 subunit expression potentiates the immobilizing action of isoflurane. Seo K, et al. Neurosci Lett, 2010 Mar 12. PMID 20097266
    4. Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of gamma-aminobutyric acid type A receptors. Fujii M, et al. J Biol Chem, 2010 Feb 12. PMID 19996098, Free PMC Article
    5. Involvement of phospholipase C-related inactive protein in the mouse reproductive system through the regulation of gonadotropin levels. Matsuda M, et al. Biol Reprod, 2009 Oct. PMID 19553601

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice.
      Title: Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice.
    2. These results suggest that PRIPs are positively involved in the development of follicles via their regulation of LH-LHR signaling and estradiol secretion.
      Title: Phospholipase C-related but catalytically inactive proteins regulate ovarian follicle development.
    3. Suppressed expression of PRIP-2 induces an elevated expression of KCC2 in the spinal cord, resulting in inhibition of nociception and amelioration of neuropathic pain in DKO mice.
      Title: Phospholipase C-related but catalytically inactive protein modulates pain behavior in a neuropathic pain model in mice.
    4. The results suggest that PRIP2 is involved in insulin-induced GABA(A) receptor insertion by recruiting active Akt to the receptor complex.
      Title: Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of gamma-aminobutyric acid type A receptors.
    5. PLC-L2 is a novel negative regulator of BCR signaling and immune responses
      Title: Role of phospholipase C-L2, a novel phospholipase C-like protein that lacks lipase activity, in B-cell receptor signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GABA receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables inositol 1,4,5 trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell proliferation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within B-1a B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of B cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cold-induced thermogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of receptor binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of synaptic transmission, GABAergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of synaptic transmission, GABAergic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inactive phospholipase C-like protein 2
    Names
    PLC-L(2)
    PLC-epsilon-2
    phospholipase C, epsilon 2
    phospholipase C-L2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013880.3 → NP_038908.2  inactive phospholipase C-like protein 2

      See identical proteins and their annotated locations for NP_038908.2

      Status: VALIDATED

      Source sequence(s)
      AB033615, AK134985, AK137821, BE983099, BY125070, CD553464
      Consensus CDS
      CCDS28875.1
      UniProtKB/Swiss-Prot
      Q3U4E2, Q80TK5, Q8K394, Q9QYG1
      Related
      ENSMUSP00000046584.7, ENSMUST00000043938.8
      Conserved Domains (4) summary
      cd00275
      Location:754 → 882
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08597
      Location:426 → 722
      PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
      cd13364
      Location:144 → 252
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd16223
      Location:272 → 415
      EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      50815893..50995522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524151.4 → XP_006524214.1  inactive phospholipase C-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006524214.1

      UniProtKB/Swiss-Prot
      Q3U4E2, Q80TK5, Q8K394, Q9QYG1
      Conserved Domains (4) summary
      cd00275
      Location:754 → 882
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08597
      Location:426 → 722
      PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
      cd13364
      Location:144 → 252
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd16223
      Location:272 → 415
      EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)

    2. XM_036160552.1 → XP_036016445.1  inactive phospholipase C-like protein 2 isoform X2

      Conserved Domains (4) summary
      cd00275
      Location:754 → 882
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08597
      Location:426 → 722
      PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
      cd13364
      Location:144 → 252
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd16223
      Location:272 → 415
      EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)

    3. XM_006524152.4 → XP_006524215.1  inactive phospholipase C-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006524215.1

      UniProtKB/Swiss-Prot
      Q3U4E2, Q80TK5, Q8K394, Q9QYG1
      Conserved Domains (4) summary
      cd00275
      Location:754 → 882
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08597
      Location:426 → 722
      PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
      cd13364
      Location:144 → 252
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd16223
      Location:272 → 415
      EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)

    4. XM_006524150.4 → XP_006524213.1  inactive phospholipase C-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006524213.1

      UniProtKB/Swiss-Prot
      Q3U4E2, Q80TK5, Q8K394, Q9QYG1
      Conserved Domains (4) summary
      cd00275
      Location:754 → 882
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08597
      Location:426 → 722
      PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
      cd13364
      Location:144 → 252
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd16223
      Location:272 → 415
      EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K394.2 GenPept UniProtKB/Swiss-Prot:Q8K394

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