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    Zmat3 zinc finger matrin type 3 [ Mus musculus (house mouse) ]

    Gene ID: 22401, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zmat3provided by MGI
    Official Full Name
    zinc finger matrin type 3provided by MGI
    Primary source
    MGI:MGI:1195270
    See related
    Ensembl:ENSMUSG00000027663 AllianceGenome:MGI:1195270
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wig1
    Summary
    Predicted to enable RNA binding activity and zinc ion binding activity. Predicted to be involved in positive regulation of apoptotic process. Predicted to act upstream of or within negative regulation of cell growth. Predicted to be located in nucleolus; nucleoplasm; and plasma membrane. Is expressed in several structures, including early conceptus and genitourinary system. Orthologous to human ZMAT3 (zinc finger matrin-type 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cortex adult (RPKM 10.5), cerebellum adult (RPKM 10.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 A3; 3 15.67 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (32388941..32419814, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (32334792..32365665, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42201 Neighboring gene predicted gene, 37770 Neighboring gene predicted gene, 57708 Neighboring gene STARR-seq mESC enhancer starr_07334 Neighboring gene RIKEN cDNA 4930429B21 gene Neighboring gene STARR-seq mESC enhancer starr_07335 Neighboring gene STARR-seq mESC enhancer starr_07336 Neighboring gene predicted gene, 54172 Neighboring gene STARR-positive B cell enhancer ABC_E7906 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of functional p53-binding motifs in the mouse wig-1 promoter. Wilhelm MT, et al. FEBS Lett, 2002 Jul 31. PMID 12135743
    2. DNA repair-deficient Xpa and Xpa/p53+/- knock-out mice: nature of the models. van Steeg H, et al. Toxicol Pathol, 2001. PMID 11695546
    3. Human wig-1, a p53 target gene that encodes a growth inhibitory zinc finger protein. Hellborg F, et al. Oncogene, 2001 Sep 6. PMID 11571644
    4. Wig-1, a new p53-induced gene encoding a zinc finger protein. Varmeh-Ziaie S, et al. Oncogene, 1997 Nov 27. PMID 9400996
    5. Consequences of Zmat3 loss in c-MYC- and mutant KRAS-driven tumorigenesis. Best SA, et al. Cell Death Dis, 2020 Oct 20. PMID 33082333, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Combined absence of TRP53 target genes ZMAT3, PUMA and p21 cause a high incidence of cancer in mice.
      Title: Combined absence of TRP53 target genes ZMAT3, PUMA and p21 cause a high incidence of cancer in mice.
    2. Consequences of Zmat3 loss in c-MYC- and mutant KRAS-driven tumorigenesis.
      Title: Consequences of Zmat3 loss in c-MYC- and mutant KRAS-driven tumorigenesis.
    3. Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program.
      Title: Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program.
    4. The Xpa/p53+/- mouse model is an excellent candidate for a future replacement of the chronic mouse bioassay for certain classes of carcinogens.
      Title: DNA repair-deficient Xpa and Xpa/p53+/- knock-out mice: nature of the models.
    5. identification of functional p53-binding motifs in promoter
      Title: Identification of functional p53-binding motifs in the mouse wig-1 promoter.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell growth TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger matrin-type protein 3
    Names
    p53-activated gene 608 protein
    wild-type p53-induced gene 1 protein
    zinc finger protein WIG-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009517.2 → NP_033543.2  zinc finger matrin-type protein 3

      See identical proteins and their annotated locations for NP_033543.2

      Status: VALIDATED

      Source sequence(s)
      AC110034, BQ895699, CD804474
      Consensus CDS
      CCDS17293.1
      UniProtKB/Swiss-Prot
      O54836
      UniProtKB/TrEMBL
      B9EI21
      Related
      ENSMUSP00000029199.6, ENSMUST00000029199.11
      Conserved Domains (2) summary
      smart00451
      Location:67 → 101
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:72 → 94
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      32388941..32419814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535441.4 → XP_006535504.1  zinc finger matrin-type protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006535504.1

      UniProtKB/Swiss-Prot
      O54836
      UniProtKB/TrEMBL
      B9EI21
      Conserved Domains (2) summary
      smart00451
      Location:67 → 101
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:72 → 94
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54836.1 GenPept UniProtKB/Swiss-Prot:O54836

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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