Ankrd54 ankyrin repeat domain 54 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ankrd54provided by MGI
Official Full Name: ankyrin repeat domain 54provided by MGI
Primary source: MGI:MGI:2444209
See related: Ensembl:ENSMUSG00000033055 AllianceGenome:MGI:2444209
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Liar; EST475269; EST1068184; C730048E16Rik
Summary: Enables protein kinase regulator activity. Acts upstream of or within several processes, including nucleocytoplasmic transport; positive regulation of erythrocyte differentiation; and regulation of protein kinase activity. Located in cytoplasm; midbody; and nucleus. Is expressed in several structures, including branchial arch; central nervous system; gut; immune system; and limb bud. Orthologous to human ANKRD54 (ankyrin repeat domain 54). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 104.4), duodenum adult (RPKM 40.9) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.7 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (78937294..78947129, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (79053094..79062927, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Liar is the first protein identified that specifically influences the nucleocytoplasmic shuttling of Btk and Txk and belongs to a rare group of known proteins carrying out this activity in a Crm1-dependent manner.
Title: Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54).
Liar is a novel Lyn-interacting molecule that plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.
Title: Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation.
Ankrd54 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Title: Tissue expression patterns identify mouse cilia genes.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within nucleocytoplasmic transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of erythrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ankyrin repeat domain-containing protein 54

Names: lyn-interacting ankyrin repeat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001378988.1 → NP_001365917.1 ankyrin repeat domain-containing protein 54 isoform 2

Status: VALIDATED

Source sequence(s)

AL589670

Conserved Domains (2) summary

sd00045
Location:141 → 172

ANK; ANK repeat [structural motif]

pfam12796
Location:117 → 205

Ank_2; Ankyrin repeats (3 copies)
NM_001378989.1 → NP_001365918.1 ankyrin repeat domain-containing protein 54 isoform 3

Status: VALIDATED

Source sequence(s)

AL589670

Conserved Domains (2) summary

sd00045
Location:141 → 172

ANK; ANK repeat [structural motif]

pfam12796
Location:117 → 205

Ank_2; Ankyrin repeats (3 copies)
NM_001378990.1 → NP_001365919.1 ankyrin repeat domain-containing protein 54 isoform 4

Status: VALIDATED

Source sequence(s)

AL589670

Conserved Domains (2) summary

sd00045
Location:141 → 172

ANK; ANK repeat [structural motif]

pfam12796
Location:117 → 198

Ank_2; Ankyrin repeats (3 copies)
NM_144849.1 → NP_659098.1 ankyrin repeat domain-containing protein 54 isoform 1

See identical proteins and their annotated locations for NP_659098.1

Status: VALIDATED

Source sequence(s)

BC014743

Consensus CDS

CCDS37139.1

UniProtKB/Swiss-Prot

Q3UPC5, Q3UZL7, Q91WK7

UniProtKB/TrEMBL

A7YB12

Related

ENSMUSP00000047042.5, ENSMUST00000040676.11

Conserved Domains (3) summary

cd00204
Location:117 → 231

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:117 → 205

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:141 → 172

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

78937294..78947129 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245584.4 → XP_011243886.1 ankyrin repeat domain-containing protein 54 isoform X2

Conserved Domains (2) summary

sd00045
Location:141 → 172

ANK; ANK repeat [structural motif]

pfam12796
Location:117 → 198

Ank_2; Ankyrin repeats (3 copies)
XM_036159352.1 → XP_036015245.1 ankyrin repeat domain-containing protein 54 isoform X3

Conserved Domains (2) summary

sd00045
Location:141 → 172

ANK; ANK repeat [structural motif]

pfam12796
Location:117 → 198

Ank_2; Ankyrin repeats (3 copies)
XM_030248498.2 → XP_030104358.1 ankyrin repeat domain-containing protein 54 isoform X1

Conserved Domains (2) summary

sd00045
Location:141 → 172

ANK; ANK repeat [structural motif]

pfam12796
Location:117 → 205

Ank_2; Ankyrin repeats (3 copies)