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    Taf6 TATA-box binding protein associated factor 6 [ Mus musculus (house mouse) ]

    Gene ID: 21343, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Taf6provided by MGI
    Official Full Name
    TATA-box binding protein associated factor 6provided by MGI
    Primary source
    MGI:MGI:109129
    See related
    Ensembl:ENSMUSG00000036980 AllianceGenome:MGI:109129
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p80; 80kDa; Taf2e; TAFII70; TAF(II)80
    Summary
    Enables DNA binding activity. Predicted to be involved in several processes, including RNA polymerase II preinitiation complex assembly; positive regulation of intrinsic apoptotic signaling pathway; and positive regulation of transcription initiation from RNA polymerase II promoter. Located in nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut gland; and retina. Orthologous to human TAF6 (TATA-box binding protein associated factor 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 50.6), ovary adult (RPKM 34.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 G2; 5 76.98 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138176879..138185713, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138178617..138187451, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene microRNA 106b Neighboring gene minichromosome maintenance complex component 7 Neighboring gene microRNA 93 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:138612151-138612338 Neighboring gene STARR-positive B cell enhancer ABC_E1693 Neighboring gene STARR-positive B cell enhancer ABC_E1694 Neighboring gene adaptor-related protein complex AP-4, mu 1 Neighboring gene STARR-seq mESC enhancer starr_14665 Neighboring gene canopy FGF signaling regulator 4 Neighboring gene metallo-beta-lactamase domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isolation of a cDNA encoding a mouse TFIID subunit containing histone H4 homology. Umehara T, et al. Gene, 1995 Aug 19. PMID 7665100
    2. Abnormal sperm in mice lacking the Taf7l gene. Cheng Y, et al. Mol Cell Biol, 2007 Apr. PMID 17242199, Free PMC Article
    3. Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening. Kurakin AV, et al. J Biol Chem, 2003 Sep 5. PMID 12829691
    4. The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation. Pointud JC, et al. J Cell Sci, 2003 May 1. PMID 12665565
    5. Global analysis of gene expression in the developing brain of Gtf2ird1 knockout mice. O'Leary J, et al. PLoS One, 2011. PMID 21909369, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aryl hydrocarbon receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SAGA complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SLIK (SAGA-like) complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of transcription factor TFTC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFTC complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription initiation factor TFIID subunit 6
    Names
    TAF(II)70
    TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80 kDa
    TAFII-70
    TAFII-80
    TAFII80
    TATA box binding protein (Tbp)-associated factor, RNA polymerase II, E
    transcription initiation factor TFIID 70 kDa subunit
    transcription initiation factor TFIID 80 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356600.1 → NP_001343529.1  transcription initiation factor TFIID subunit 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All four transcripts encode the same protein.
      Source sequence(s)
      AC151719
      Consensus CDS
      CCDS19795.1
      UniProtKB/Swiss-Prot
      Q62311
      Conserved Domains (2) summary
      COG5095
      Location:9 → 408
      TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]
      cd08050
      Location:214 → 430
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    2. NM_001356601.1 → NP_001343530.1  transcription initiation factor TFIID subunit 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four transcripts encode the same protein.
      Source sequence(s)
      AC151719
      Consensus CDS
      CCDS19795.1
      UniProtKB/Swiss-Prot
      Q62311
      Conserved Domains (2) summary
      COG5095
      Location:9 → 408
      TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]
      cd08050
      Location:214 → 430
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    3. NM_001356602.1 → NP_001343531.1  transcription initiation factor TFIID subunit 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four transcripts encode the same protein.
      Source sequence(s)
      AC151719
      Consensus CDS
      CCDS19795.1
      UniProtKB/Swiss-Prot
      Q62311
      Related
      ENSMUSP00000106561.2, ENSMUST00000110936.8
      Conserved Domains (2) summary
      COG5095
      Location:9 → 408
      TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]
      cd08050
      Location:214 → 430
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    4. NM_009315.4 → NP_033341.1  transcription initiation factor TFIID subunit 6

      See identical proteins and their annotated locations for NP_033341.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four transcripts encode the same protein.
      Source sequence(s)
      AC151719
      Consensus CDS
      CCDS19795.1
      UniProtKB/Swiss-Prot
      Q62311
      Related
      ENSMUSP00000048016.8, ENSMUST00000048698.14
      Conserved Domains (2) summary
      COG5095
      Location:9 → 408
      TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]
      cd08050
      Location:214 → 430
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      138176879..138185713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240940.2 → XP_011239242.1  transcription initiation factor TFIID subunit 6 isoform X1

      See identical proteins and their annotated locations for XP_011239242.1

      Conserved Domains (2) summary
      pfam02969
      Location:11 → 76
      TAF; TATA box binding protein associated factor (TAF)
      cd08050
      Location:214 → 441
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    2. XM_011240936.2 → XP_011239238.1  transcription initiation factor TFIID subunit 6 isoform X1

      See identical proteins and their annotated locations for XP_011239238.1

      Conserved Domains (2) summary
      pfam02969
      Location:11 → 76
      TAF; TATA box binding protein associated factor (TAF)
      cd08050
      Location:214 → 441
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    3. XM_030254353.2 → XP_030110213.1  transcription initiation factor TFIID subunit 6 isoform X2

      UniProtKB/Swiss-Prot
      Q62311
      Conserved Domains (2) summary
      COG5095
      Location:9 → 408
      TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]
      cd08050
      Location:214 → 430
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    4. XM_011240939.3 → XP_011239241.1  transcription initiation factor TFIID subunit 6 isoform X1

      See identical proteins and their annotated locations for XP_011239241.1

      Conserved Domains (2) summary
      pfam02969
      Location:11 → 76
      TAF; TATA box binding protein associated factor (TAF)
      cd08050
      Location:214 → 441
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    5. XM_011240938.3 → XP_011239240.1  transcription initiation factor TFIID subunit 6 isoform X1

      See identical proteins and their annotated locations for XP_011239240.1

      Conserved Domains (2) summary
      pfam02969
      Location:11 → 76
      TAF; TATA box binding protein associated factor (TAF)
      cd08050
      Location:214 → 441
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    6. XM_036164984.1 → XP_036020877.1  transcription initiation factor TFIID subunit 6 isoform X1

      Conserved Domains (2) summary
      pfam02969
      Location:11 → 76
      TAF; TATA box binding protein associated factor (TAF)
      cd08050
      Location:214 → 441
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    7. XM_011240937.3 → XP_011239239.1  transcription initiation factor TFIID subunit 6 isoform X1

      See identical proteins and their annotated locations for XP_011239239.1

      Conserved Domains (2) summary
      pfam02969
      Location:11 → 76
      TAF; TATA box binding protein associated factor (TAF)
      cd08050
      Location:214 → 441
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    8. XM_030254354.2 → XP_030110214.1  transcription initiation factor TFIID subunit 6 isoform X2

      UniProtKB/Swiss-Prot
      Q62311
      Conserved Domains (2) summary
      COG5095
      Location:9 → 408
      TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]
      cd08050
      Location:214 → 430
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62311.1 GenPept UniProtKB/Swiss-Prot:Q62311

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