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    Mknk1 MAP kinase-interacting serine/threonine kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 17346, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mknk1provided by MGI
    Official Full Name
    MAP kinase-interacting serine/threonine kinase 1provided by MGI
    Primary source
    MGI:MGI:894316
    See related
    Ensembl:ENSMUSG00000028708 AllianceGenome:MGI:894316
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mnk1; 2410048M24Rik
    Summary
    This gene encodes a serine-threonine protein kinase that is activated by extracellular signal-regulated kinase or p38 mitogen-activated protein kinases, and it may function in cytokine and environmental stress responses. This kinase is required for phosphorylation of eukaryotic translation initiation factor 4E but it is not required for cell growth during development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013]
    Expression
    Ubiquitous expression in thymus adult (RPKM 21.1), lung adult (RPKM 18.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D1; 4 53.06 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115695140..115736453)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115837943..115879256)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 1 Neighboring gene MOB kinase activator 3C Neighboring gene STARR-seq mESC enhancer starr_11125 Neighboring gene STARR-positive B cell enhancer ABC_E1650 Neighboring gene STARR-positive B cell enhancer ABC_E6199 Neighboring gene kinocilin Neighboring gene transmembrane protein 275

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MAPK-interacting kinase 1 regulates platelet production, activation, and thrombosis. Manne BK, et al. Blood, 2022 Dec 8. PMID 35930749, Free PMC Article
    2. Mnk1 is a novel acinar cell-specific kinase required for exocrine pancreatic secretion and response to pancreatitis in mice. Cendrowski J, et al. Gut, 2015 Jun. PMID 25037190
    3. Prion formation correlates with activation of translation-regulating protein 4E-BP and neuronal transcription factor Elk1. Allard EK, et al. Neurobiol Dis, 2013 Oct. PMID 23742760
    4. Mnk Kinases in Cytokine Signaling and Regulation of Cytokine Responses. Joshi S, et al. Biomol Concepts, 2012 Apr. PMID 23710261, Free PMC Article
    5. Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity. Sandeman LY, et al. Mol Metab, 2020 Dec. PMID 32712434, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-370-3p Regulates Adipogenesis through Targeting Mknk1.
      Title: miR-370-3p Regulates Adipogenesis through Targeting Mknk1.
    2. Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity.
      Title: Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity.
    3. phosphorylation pattern of eIF4E responds faithfully to Rapamycin inhibition, the prolonged exposure to Rapamycin rescues the loss of eIF4E phosphorylation through Mnk1 activation.
      Title: Eukaryotic initiation factor 4E is a novel effector of mTORC1 signaling pathway in cross talk with Mnk1.
    4. MNK1 participates in mediating high-fat diet-induced insulin resistance. Our findings reveal distinct roles for the MNKs in a novel area of disease biology
      Title: MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways.
    5. data suggest a physiological role for MNK1a-Ser(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E phosphorylation in vitro and in vivo.
      Title: AMP-activated Protein Kinase Up-regulates Mitogen-activated Protein (MAP) Kinase-interacting Serine/Threonine Kinase 1a-dependent Phosphorylation of Eukaryotic Translation Initiation Factor 4E.
    6. Mnk1 is a novel pancreatic acinar cell-specific stress response kinase that regulates digestive enzyme abundance and eIF4E phosphorylation.
      Title: Mnk1 is a novel acinar cell-specific kinase required for exocrine pancreatic secretion and response to pancreatitis in mice.
    7. Long-term potentiation (LTP) consolidation in the dentate gyrus of live rodents requires sustained (hours) BDNF-TrkB signaling and from TrkB to MAP-kinase-interacting kinase.
      Title: Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK.
    8. Data suggest that Mnk1 and Mnk2 regulate cell migration/wound healing, expression of vimentin, stability of vimentin protein, and binding of eIF4E (eukaryotic translation initiation factor 4E) and Cyfip1 (cytoplasmic FMR1 interacting protein 1).
      Title: The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding.
    9. Mnk1/2 has a minimal role in T cell development and activation but may regulate non-T cell lineages to control Th1 and Th17 differentiation in vivo.
      Title: Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis.
    10. oncogenic role for Mnk1/2 in tumor development
      Title: Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to salt stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MAP kinase-interacting serine/threonine-protein kinase 1
    Names
    MAPK signal-integrating kinase 1
    NP_001272416.1
    NP_001272417.1
    NP_001342103.1
    NP_001356167.1
    NP_067436.1
    XP_006502885.1
    XP_006502888.1
    XP_030109148.1
    XP_036019677.1
    XP_036019678.1
    XP_036019679.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285487.1 → NP_001272416.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform a

      See identical proteins and their annotated locations for NP_001272416.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK141298, AL627085, BB841753, BQ551007, BY209061, CN538557, CO425179
      UniProtKB/TrEMBL
      Q3TDV2, Q3U1I8
      Related
      ENSMUST00000144235.8
      Conserved Domains (1) summary
      cd14174
      Location:40 → 328
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    2. NM_001285488.1 → NP_001272417.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform b

      See identical proteins and their annotated locations for NP_001272417.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
      Source sequence(s)
      AK141298, AL627085, BQ551007, BY209061, CN538557, CO425179
      Consensus CDS
      CCDS18498.1
      UniProtKB/TrEMBL
      A2A8W8, Q3TDV2
      Related
      ENSMUSP00000102123.4, ENSMUST00000106513.10
      Conserved Domains (2) summary
      smart00220
      Location:41 → 321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14174
      Location:34 → 322
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    3. NM_001355174.1 → NP_001342103.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AK141298, BP762163, BQ551007, BY209061, CN538557, CO425179
      Conserved Domains (1) summary
      cd14174
      Location:34 → 322
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    4. NM_001369238.1 → NP_001356167.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL627085
      UniProtKB/TrEMBL
      Q3TDV2
      Conserved Domains (1) summary
      cl21453
      Location:34 → 290
      PKc_like; Protein Kinases, catalytic domain

    5. NM_021461.5 → NP_067436.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform b

      See identical proteins and their annotated locations for NP_067436.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
      Source sequence(s)
      AK141298, BQ551007, BY209061, CN538557, CO425179
      Consensus CDS
      CCDS18498.1
      UniProtKB/TrEMBL
      A2A8W8, Q3TDV2
      Related
      ENSMUSP00000019677.6, ENSMUST00000019677.12
      Conserved Domains (2) summary
      smart00220
      Location:41 → 321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14174
      Location:34 → 322
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      115695140..115736453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163785.1 → XP_036019678.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5

      Conserved Domains (1) summary
      cd14174
      Location:34 → 322
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    2. XM_006502822.4 → XP_006502885.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_006502885.1

      UniProtKB/TrEMBL
      Q3TDV2, Q3U1I8
      Conserved Domains (1) summary
      cd14174
      Location:40 → 328
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    3. XM_006502825.4 → XP_006502888.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3

      Conserved Domains (1) summary
      cd14174
      Location:40 → 328
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    4. XM_036163784.1 → XP_036019677.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

      UniProtKB/TrEMBL
      Q3TDV2
      Conserved Domains (1) summary
      cd14174
      Location:38 → 326
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    5. XM_036163786.1 → XP_036019679.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X6

      Conserved Domains (1) summary
      cl21453
      Location:31 → 235
      PKc_like; Protein Kinases, catalytic domain

    6. XM_030253288.2 → XP_030109148.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

      Conserved Domains (1) summary
      cd14174
      Location:38 → 326
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08605.2 GenPept UniProtKB/Swiss-Prot:O08605

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