Hrh4 histamine receptor H4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hrh4provided by RGD
Official Full Name: histamine receptor H4provided by RGD
Primary source: RGD:620631
See related: Ensembl:ENSRNOG00000016887 AllianceGenome:RGD:620631
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables histamine receptor activity. Involved in inflammatory response. Predicted to be located in membrane. Predicted to be active in dendrite and synapse. Predicted to be integral component of plasma membrane. Orthologous to human HRH4 (histamine receptor H4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 1.2), Thymus (RPKM 1.1) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 18p13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (4440977..4457132)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (4166270..4182426)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (4365429..4382599)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

H4R expression increased in a rat model of lipopolysaccharide (LPS)-induced CNS inflammation. Knockdown of H4R in microglia HAPI cells enhanced the production of cytokines following LPS stimulation. Co-immunoprecipitation experiments further revealed an interaction between H4R and tumor necrosis factor receptor-associated factor 6 (TRAF6) in microglia, which was verified both in vivo and in vitro.
Title: H4 Receptor Inhibits Lipopolysaccharide-induced NF-κB Activation by Interacting with Tumor Necrosis Factor Receptor-Associated Factor 6.
the present study found that blocking H4R exerted a significant anti-inflammatory effect at 2 h after Lipopolysaccharide injection and inhibited pro-inflammatory Tumor Necrosis Factor-alpha- and NF-kappaB expression
Title: Regulation of TNF-α and NF-κB activation through the JAK/STAT signaling pathway downstream of histamine 4 receptor in a rat model of LPS-induced joint inflammation.
Data indicate that positive histamine H4 receptor (HRH4) immunostaining was detected in Leydig cells of all testicular sections.
Title: H4 histamine receptors inhibit steroidogenesis and proliferation in Leydig cells.
H3 and H4 receptors in endothelial cells are potentially important for regulation of blood-brain barrier permeability, including trafficking of immunocompetent cells
Title: Expression of histamine receptor genes Hrh3 and Hrh4 in rat brain endothelial cells.
The H4 receptor is expressed in the kidney mainly by resident renal cells of the loop of Henle and is significantly overexpressed in diabetic animals, suggesting a possible role in the pathogenesis of diabetes-associated renal disease
Title: Overexpression of histamine H₄ receptors in the kidney of diabetic rat.
DAO secretion may contribute to the catabolism of histamine released during fat absorption and this is probably mediated through the histamine H(4) receptor.
Title: Lymphatic diamine oxidase secretion stimulated by fat absorption is linked with histamine release.
Histamine inhibits lipopolysaccharide-induced interleukin (IL)-1beta release in hippocampal organotypic slice cultures.
Title: Histamine modulates microglia function.
H4 receptors are the primary receptors involved in effective histaminergic regulation of the excitability of vestibular primary neurons.
Title: Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability.
analysis of fragment optimization and analysis of binding kinetics for ligand based design of novel histamine H receptor antagonists
Title: Ligand based design of novel histamine H₄ receptor antagonists; fragment optimization and analysis of binding kinetics.
The present data suggest for the first time a possible ulcerogenic role mediated by histamine H4 receptors in the rat gastric mucosa
Title: Selective histamine H₃ and H₄ receptor agonists exert opposite effects against the gastric lesions induced by HCl in the rat stomach.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled acetylcholine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables histamine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables histamine receptor activity	IEA Inferred from Electronic Annotation more info
enables histamine receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled serotonin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: histamine H4 receptor

Names: H4R; HH4R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131909.2 → NP_571984.2 histamine H4 receptor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

Q91ZY1

UniProtKB/TrEMBL

A6KLT2, G3V868

Related

ENSRNOP00000022744.2, ENSRNOT00000022744.5

Conserved Domains (2) summary

cd14964
Location:17 → 43

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:16 → 376

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily