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    ZNF467 zinc finger protein 467 [ Homo sapiens (human) ]

    Gene ID: 168544, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF467provided by HGNC
    Official Full Name
    zinc finger protein 467provided by HGNC
    Primary source
    HGNC:HGNC:23154
    See related
    Ensembl:ENSG00000181444 MIM:614040; AllianceGenome:HGNC:23154
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EZI; Zfp467
    Summary
    The protein encoded by this gene is a zinc finger protein whose function has not yet been elucidated in humans. However, the mouse ortholog of this protein enhances adipocyte differentiation and suppresses osteoblast differentiation in bone marrow. The mouse protein also is a transcription factor for several genes and can help recruit histone deacetylase complexes. [provided by RefSeq, Aug 2016]
    Expression
    Ubiquitous expression in spleen (RPKM 2.9), kidney (RPKM 2.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    7q36.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149764182..149776530, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (150946102..150958226, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (149461271..149470677, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149412332-149412964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149417350-149418244 Neighboring gene KRAB-A domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149432150-149433066 Neighboring gene uncharacterized LOC124901771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149438995-149439524 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149463303-149463978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18767 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18768 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149479128-149479704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149480282-149480858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149480859-149481434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149482621-149483120 Neighboring gene Sharpr-MPRA regulatory region 4172 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149484857-149485446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149487626-149488414 Neighboring gene SCO-spondin, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149496913-149497414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149497415-149497914 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18769 Neighboring gene zinc finger protein 862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149552405-149552958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149552959-149553510 Neighboring gene ATP6V0E2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149570857-149571825 Neighboring gene ATPase H+ transporting V0 subunit e2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Functional expression of ZNF467 and PCBP2 supports adipogenic lineage commitment in adipose-derived mesenchymal stem cells. Gluscevic M, et al. Gene, 2020 May 5. PMID 32032745
    2. Zinc finger protein 467 is a novel regulator of osteoblast and adipocyte commitment. Quach JM, et al. J Biol Chem, 2011 Feb 11. PMID 21123171, Free PMC Article
    3. Altered DNA methylation profile in idiopathic pulmonary fibrosis. Sanders YY, et al. Am J Respir Crit Care Med, 2012 Sep 15. PMID 22700861, Free PMC Article
    4. Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms. Saijou E, et al. J Biol Chem, 2007 Nov 2. PMID 17848547
    5. A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3. Nakayama K, et al. EMBO J, 2002 Nov 15. PMID 12426389, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. demonstrate that PCBP2 and ZNF467 impact adipogenic but not osteogenic differentiation, further supporting evidence that AMSCs and BMSCs appear to be adapted to their microenvironment
      Title: Functional expression of ZNF467 and PCBP2 supports adipogenic lineage commitment in adipose-derived mesenchymal stem cells.
    2. ZNF467 gene DNA methylation is importants in the pathogenesis of idiopathic pulmonary fibrosis.
      Title: Altered DNA methylation profile in idiopathic pulmonary fibrosis.
    3. These results identify EZI as a novel cargo protein for importin-7 and demonstrate a nucleocytoplasmic shuttling mechanism that is mediated by importin-7-dependent nuclear localization and CRM1-independent nuclear export.
      Title: Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 467
    Names
    zinc finger protein EZI

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329856.2 → NP_001316785.1  zinc finger protein 467 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in the coding region compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC004877, BC038972, CV575107
      Consensus CDS
      CCDS87563.1
      UniProtKB/TrEMBL
      C9JAX3
      Related
      ENSP00000418011.1, ENST00000484747.5

    2. NM_207336.3 → NP_997219.1  zinc finger protein 467 isoform 1

      See identical proteins and their annotated locations for NP_997219.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC004877, BC038972, BC052625, CV575107
      Consensus CDS
      CCDS5899.1
      UniProtKB/Swiss-Prot
      Q7Z7K2
      Related
      ENSP00000304769.3, ENST00000302017.4
      Conserved Domains (2) summary
      COG5048
      Location:190 → 565
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:218 → 238
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      149764182..149776530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419936.1 → XP_047275892.1  zinc finger protein 467 isoform X4

      UniProtKB/Swiss-Prot
      Q7Z7K2

    2. XM_017011799.3 → XP_016867288.2  zinc finger protein 467 isoform X2

    3. XM_011515857.4 → XP_011514159.2  zinc finger protein 467 isoform X1

    4. XM_006715864.5 → XP_006715927.1  zinc finger protein 467 isoform X3

      Conserved Domains (4) summary
      COG5048
      Location:231 → 606
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:257 → 279
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:271 → 296
      zf-H2C2_2; Zinc-finger double domain

    5. XM_047419937.1 → XP_047275893.1  zinc finger protein 467 isoform X1

    6. XM_005249961.6 → XP_005250018.1  zinc finger protein 467 isoform X4

      See identical proteins and their annotated locations for XP_005250018.1

      UniProtKB/Swiss-Prot
      Q7Z7K2
      Conserved Domains (2) summary
      COG5048
      Location:190 → 565
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:218 → 238
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_005249960.6 → XP_005250017.1  zinc finger protein 467 isoform X4

      See identical proteins and their annotated locations for XP_005250017.1

      UniProtKB/Swiss-Prot
      Q7Z7K2
      Conserved Domains (2) summary
      COG5048
      Location:190 → 565
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:218 → 238
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. XM_005249959.5 → XP_005250016.1  zinc finger protein 467 isoform X4

      See identical proteins and their annotated locations for XP_005250016.1

      UniProtKB/Swiss-Prot
      Q7Z7K2
      Conserved Domains (2) summary
      COG5048
      Location:190 → 565
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:218 → 238
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      150946102..150958226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357394.1 → XP_054213369.1  zinc finger protein 467 isoform X4

    2. XM_054357389.1 → XP_054213364.1  zinc finger protein 467 isoform X2

    3. XM_054357388.1 → XP_054213363.1  zinc finger protein 467 isoform X1

    4. XM_054357391.1 → XP_054213366.1  zinc finger protein 467 isoform X3

    5. XM_054357396.1 → XP_054213371.1  zinc finger protein 467 isoform X1

    6. XM_054357392.1 → XP_054213367.1  zinc finger protein 467 isoform X4

    7. XM_054357395.1 → XP_054213370.1  zinc finger protein 467 isoform X4

    8. XM_054357390.1 → XP_054213365.1  zinc finger protein 467 isoform X3

    9. XM_054357393.1 → XP_054213368.1  zinc finger protein 467 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z7K2.1 GenPept UniProtKB/Swiss-Prot:Q7Z7K2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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