Hoxb13 homeobox B13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hoxb13provided by MGI
Official Full Name: homeobox B13provided by MGI
Primary source: MGI:MGI:107730
See related: Ensembl:ENSMUSG00000049604 AllianceGenome:MGI:107730
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and methyl-CpG binding activity. Acts upstream of or within epithelial cell maturation involved in prostate gland development; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; and regulation of growth. Part of transcription regulator complex. Is expressed in several structures, including genitourinary system; gut; lung; spinal cord; and tail. Human ortholog(s) of this gene implicated in ductal carcinoma in situ and renal cell carcinoma. Orthologous to human HOXB13 (homeobox B13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward colon adult (RPKM 258.3) See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 59.63 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (96085142..96087436)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (96194316..96196610)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of HOXB13 expression patterns in localized and metastatic castration-resistant prostate cancer.
Title: Characterization of HOXB13 expression patterns in localized and metastatic castration-resistant prostate cancer.
Hierarchical Phosphorylation of HOXB13 by mTOR Dictates Its Activity and Oncogenic Function in Prostate Cancer.
Title: Hierarchical Phosphorylation of HOXB13 by mTOR Dictates Its Activity and Oncogenic Function in Prostate Cancer.
HOXB13 facilitates hepatocellular carcinoma progression by activating AKT/mTOR signaling pathway.
Title: HOXB13 facilitates hepatocellular carcinoma progression by activating AKT/mTOR signaling pathway.
Cauda equina paragangliomas express HOXB13.
Title: Cauda equina paragangliomas express HOXB13.
results demonstrate that Meis1 and Hoxb13 act cooperatively to regulate cardiomyocyte maturation and proliferation and provide mechanistic insights into the link between hyperplastic and hypertrophic growth of cardiomyocytes
Title: A calcineurin-Hoxb13 axis regulates growth mode of mammalian cardiomyocytes.
Cdx and Wnt mutations and premature Hox13 expression also cause similar neural dysmorphology
Title: Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone.
Hoxb13 has a negative effect on skin wound repair
Title: Persistent inflammation and angiogenesis during wound healing in K14-directed Hoxb13 transgenic mice.
Data demonstrate that FOXA1 directly regulates HOXB13 in human prostate epithelial cells, and show that this prostate-specific regulatory mechanism is conserved in mice.
Title: A FOXA1-binding enhancer regulates Hoxb13 expression in the prostate gland.
Hoxb13 cis-regulatory elements provide a powerful tool to achieve androgen-independent transgene expression in the prostate and distal colon-specific expression in the gastrointestinal tract
Title: Hoxb13 regulatory elements mediate transgene expression during prostate organogenesis and carcinogenesis.
Epidermal HOXB13 signal was detected over the entire body surface, but surprisingly, essentially all of the signal was cytoplasmic in developing skin
Title: HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hoxb13 (e-PCR), detects polymorphism
- UniSTS:143380

Hoxb13 (e-PCR), detects polymorphism
- UniSTS:536648

Hoxb13 (e-PCR), detects polymorphism
- UniSTS:166553

Hoxb13 (e-PCR), detects polymorphism
- UniSTS:166554

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables methyl-CpG binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within epithelial cell maturation involved in prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within morphogenesis of an epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: homeobox protein Hox-B13

Names: homeo box B13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.