Has1 hyaluronan synthase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Has1provided by MGI
Official Full Name: hyaluronan synthase 1provided by MGI
Primary source: MGI:MGI:106590
See related: Ensembl:ENSMUSG00000003665 AllianceGenome:MGI:106590
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HAS
Summary: Enables hyaluronan synthase activity. Involved in extracellular matrix assembly and extracellular polysaccharide biosynthetic process. Acts upstream of or within hyaluronan biosynthetic process. Located in cytoplasm and membrane. Is expressed in several structures, including alimentary system epithelium; face; gonad; heart; and skin. Orthologous to human HAS1 (hyaluronan synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 1.3), lung adult (RPKM 1.2) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.2; 17 10.53 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (18063588..18075450, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (17833691..17855589, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

deficiency impeded post-natal formation of the retrocalcaneal bursa, implicating HAS1 in regulating hyaluronan metabolism by cells lining the bursal cavity
Title: Knockout of hyaluronan synthase 1, but not 3, impairs formation of the retrocalcaneal bursa.
In the present study, we examined expression patterns of Has1, -2, -3 mRNA in developing mouse molar and incisor tooth germs from embryonic day (E) 11.5 to postnatal day (P) 7, focusing on Hertwig's epithelial root sheath (HERS) and the apical bud in particular. Has1 mRNA expression was not detected in all tooth germs examined
Title: An in situ hybridization study of Hyaluronan synthase (Has) mRNA in developing mouse molar and incisor tooth germs.
HAS1 was significantly upregulated at the level of gene expression during muscle hypertrophy.
Title: Hyaluronic acid, HAS1, and HAS2 are significantly upregulated during muscle hypertrophy.
analysis of changes in cervical glycosaminoglycan composition during normal pregnancy and preterm birth: Has1 is expressed in preterm birth, while Has2 is induced at term
Title: Dynamic changes in cervical glycosaminoglycan composition during normal pregnancy and preterm birth.
Selective loss of Has1 and Has3 leads to a proinflammatory milieu that favors recruitment of neutrophils and other inflammation-related changes in the dermis.
Title: Enhanced inflammation and accelerated wound closure following tetraphorbol ester application or full-thickness wounding in mice lacking hyaluronan synthases Has1 and Has3.
repression of HA-accumulation by both COX-2 selective and non-selective COX inhibition implicates COX-2 in the regulation of HA synthesis via stimulation of HAS1 and HAS2 expression in vivo
Title: Cyclooxygenase inhibitors repress vascular hyaluronan-synthesis in murine atherosclerosis and neointimal thickening.
proper regulation of the expression of each HAS isoform is required for optimal malignant transformation and tumor growth
Title: Selective expression and functional characteristics of three mammalian hyaluronan synthases in oncogenic malignant transformation.
expressed throughout the gastrulating embryo
Title: Three vertebrate hyaluronan synthases are expressed during mouse development in distinct spatial and temporal patterns.
Has-1 transduced ASMCs accumulated the greatest amount of HA containing ECM than the other transduced ASMCs.Confocal microscopy showed CD44 positive monocytes bound to hyaluronidase sensitive ECM in has-1 transduced ASMCs.
Title: Overexpression of hyaluronan synthases alters vascular smooth muscle cell phenotype and promotes monocyte adhesion.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

General gene information

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Markers

AW488161 (e-PCR)
- UniSTS:209275

D82964 (e-PCR)
- UniSTS:209276

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hyaluronan synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hyaluronan synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to platelet-derived growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in extracellular polysaccharide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular polysaccharide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hyaluronan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hyaluronan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hyaluronan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hyaluronan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hyaluronan synthase 1

Names: HA synthase 1; hyaluronan synthase1; hyaluronate synthase 1; hyaluronic acid synthase 1

NP_032241.1

EC 2.4.1.212

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008215.2 → NP_032241.1 hyaluronan synthase 1

See identical proteins and their annotated locations for NP_032241.1

Status: VALIDATED

Source sequence(s)

AK138203, AW488161, D82964

Consensus CDS

CCDS37459.1

UniProtKB/Swiss-Prot

Q61647

UniProtKB/TrEMBL

Q05A37

Related

ENSMUSP00000003762.7, ENSMUST00000003762.8

Conserved Domains (2) summary

TIGR04242
Location:51 → 493

nodulat_NodC; chitooligosaccharide synthase NodC

cl11394
Location:100 → 391

Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold