Abcc3 ATP binding cassette subfamily C member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abcc3provided by RGD
Official Full Name: ATP binding cassette subfamily C member 3provided by RGD
Primary source: RGD:71101
See related: Ensembl:ENSRNOG00000002948 AllianceGenome:RGD:71101
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mlp2; Mrp3
Summary: Enables ABC-type bile acid transporter activity. Involved in several processes, including anion transport; response to estradiol; and response to lipopolysaccharide. Acts upstream of or within canalicular bile acid transport. Located in basolateral plasma membrane. Biomarker of several diseases, including bilirubin metabolic disorder (multiple); fatty liver disease (multiple); hepatocellular carcinoma; hyperprolactinemia; and kidney disease (multiple). Orthologous to human ABCC3 (ATP binding cassette subfamily C member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 94.4), Kidney (RPKM 69.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (79793571..79839528, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (79296681..79342749, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (82047308..82116928, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This report is the first to describe liver overexpression of Abcc3 during the cancer initiation, promotion, and progression periods in rat hepatocarcinogenesis model and in human hepatocellular carcinoma
Title: The transmembrane transporter ABCC3 participates in liver cancer progression and is a potential biomarker.
Ethynylestradiol increased the expression of hepatic Mrp3 transcriptionally and independently of any cholestatic manifestation and required participation of an ER, most likely ER-alpha, through its phosphorylation.
Title: Induction of hepatic multidrug resistance-associated protein 3 by ethynylestradiol is independent of cholestasis and mediated by estrogen receptor.
In olfactory epithelium, high levels of expression of xenobiotic transporters Mrp1, Mrp3, Mrp5, Mdr1a, Oatp2 and Oat6 are expressed.
Title: Expression and differential localization of xenobiotic transporters in the rat olfactory neuro-epithelium.
Conjugated bilirubin induces the mRNA expression of MRP2, which is a determinant of the in vivo cisplatin resistance of rat hepatoma cells
Title: Conjugated bilirubin induces multidrug resistance-associated protein 2 mRNA expression and in vivo cisplatin resistance in rat hepatoma AH66 cells.
Efflux of F-MTX is mediated by Mrp3 on the basolateral membrane of IEC-6 cells.
Title: Transport of fluorescein methotrexate by multidrug resistance-associated protein 3 in IEC-6 cells.
During liver regeneration after critical hepatectomy such as 90% hepatectomy, decrease of MRP2 and expression of MRP3 may play an important role in postoperative hyperbilirubinemia.
Title: Expression of MRP2 and MRP3 during liver regeneration after 90% partial hepatectomy in rats.
high expression of rat MRP3 in ileum and colon
Title: Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine.
The mRNA induction of MDR1, MRP1, MRP2 and MRP3 by rifampicin (Rif), dexamethasone (Dex) and omeprazole (Ome) was investigated in primary cultures of cryopreserved human and rat hepatocytes.
Title: Regulation of mRNA expression of MDR1, MRP1, MRP2 and MRP3 by prototypical microsomal enzyme inducers in primary cultures of human and rat hepatocytes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type bile acid transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ABC-type glutathione S-conjugate transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type glutathione S-conjugate transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type glutathione S-conjugate transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ABC-type xenobiotic transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type xenobiotic transporter activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ATPase-coupled transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables glucuronoside transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables glucuronoside transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables icosanoid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables icosanoid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within canalicular bile acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glucuronoside transport	IEA Inferred from Electronic Annotation more info
involved_in leukotriene transport	IEA Inferred from Electronic Annotation more info
involved_in leukotriene transport	ISO Inferred from Sequence Orthology more info
involved_in leukotriene transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic anion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to tetrachloromethane	IEP Inferred from Expression Pattern more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-binding cassette sub-family C member 3

Names: ATP-binding cassette, sub-family C (CFTR/MRP), member 3; ATP-binding cassette, subfamily C (CFTR/MRP), member 3; MLP-2; MRP-like protein 2; canalicular multispecific organic anion transporter 2; multidrug resistance protein 3; multidrug resistance-associated protein 3; organic anion transporter

NP_542148.2

EC 7.6.2.2

EC 7.6.2.3

XP_017452457.1

EC 7.6.2.2

EC 7.6.2.3

XP_017452459.1

EC 7.6.2.2

EC 7.6.2.3

XP_017452460.1

EC 7.6.2.2

EC 7.6.2.3

XP_038941015.1

EC 7.6.2.2

EC 7.6.2.3

XP_063124411.1

EC 7.6.2.2

EC 7.6.2.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080581.2 → NP_542148.2 ATP-binding cassette sub-family C member 3

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

O88270, O88563

UniProtKB/TrEMBL

A0A0G2JU97, A6HI45

Related

ENSRNOP00000069018.2, ENSRNOT00000085451.2

Conserved Domains (1) summary

TIGR00957
Location:7 → 1522

MRP_assoc_pro; multi drug resistance-associated protein (MRP)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

79793571..79839528 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268341.1 → XP_063124411.1 ATP-binding cassette sub-family C member 3 isoform X1
XM_039085087.2 → XP_038941015.1 ATP-binding cassette sub-family C member 3 isoform X1

Conserved Domains (1) summary

TIGR00957
Location:1 → 1211

MRP_assoc_pro; multi drug resistance-associated protein (MRP)
XM_017596968.3 → XP_017452457.1 ATP-binding cassette sub-family C member 3 isoform X2

UniProtKB/TrEMBL

A6HI46
XM_017596971.3 → XP_017452460.1 ATP-binding cassette sub-family C member 3 isoform X3

UniProtKB/TrEMBL

A6HI46
XM_017596970.3 → XP_017452459.1 ATP-binding cassette sub-family C member 3 isoform X3

UniProtKB/TrEMBL

A6HI46