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    Ugt1a6 UDP glucuronosyltransferase family 1 member A6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 113992, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Ugt1a6provided by RGD
    Official Full Name
    UDP glucuronosyltransferase family 1 member A6provided by RGD
    Primary source
    RGD:620949
    See related
    Ensembl:ENSRNOG00000018740 AllianceGenome:RGD:620949
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ugt1; Udpgt; Ugt1a7; UDPGT 1-6
    Summary
    Enables glucuronosyltransferase activity. Involved in several processes, including 4-chlorobiphenyl metabolic process; cellular response to glucocorticoid stimulus; and response to lipopolysaccharide. Located in intracellular membrane-bounded organelle. Part of protein-containing complex. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hepatitis B. Orthologous to human UGT1A6 (UDP glucuronosyltransferase family 1 member A6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 1922.0), Kidney (RPKM 1019.5) and 3 other tissues See more
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    Genomic context

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    Location:
    9q35
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (96195018..96256264)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (88747213..88808465)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (95241609..95302822)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 40 Neighboring gene UDP glucuronosyltransferase family 1 member A9 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A9, pseudogene Neighboring gene uncharacterized LOC108351970 Neighboring gene UDP glucuronosyltransferase family 1 member A8 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7C Neighboring gene UDP glycosyltransferase 1 family, polypeptide A4, pseudogene Neighboring gene UDP glucuronosyltransferase family 1 member A5 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A3 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B3 Neighboring gene UDP glucuronosyltransferase family 1 member A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene Holliday junction recognition protein Neighboring gene transient receptor potential cation channel, subfamily M, member 8 Neighboring gene peptidylprolyl isomerase D, pseudogene 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Effects of β-Naphthoflavone on Ugt1a6 and Ugt1a7 Expression in Rat Brain. Sakakibara Y, et al. Biol Pharm Bull, 2016. PMID 26725430
    2. Regulation of the rat UGT1A6 by glucocorticoids involves a cryptic glucocorticoid response element. Falkner KC, et al. Drug Metab Dispos, 2008 Feb. PMID 18039810, Free PMC Article
    3. Activation of glucuronidation through reduction of a disulfide bond in rat UDP-glucuronosyltransferase 1A6. Ikushiro S, et al. Biochemistry, 2002 Oct 22. PMID 12379124
    4. Molecular basis of perinatal changes in UDP-glucuronosyltransferase activity in maternal rat liver. Luquita MG, et al. J Pharmacol Exp Ther, 2001 Jul. PMID 11408524
    5. Cloning and characterization of cDNA encoding 3-methylcholanthrene inducible rat mRNA for UDP-glucuronosyltransferase. Iyanagi T, et al. J Biol Chem, 1986 Nov 25. PMID 3096993

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bile duct ligation elevates 5-HT levels in cerebral cortex of rats partly due to impairment of brain UGT1A6 expression and activity via ammonia accumulation.
      Title: Bile duct ligation elevates 5-HT levels in cerebral cortex of rats partly due to impairment of brain UGT1A6 expression and activity via ammonia accumulation.
    2. study indicated that Status Epilepticus altered the expression of brain Ugt1a1 and Ugt1a7, which could alter glucuronidation in the brain.
      Title: Effect of status epilepticus on expression of brain UDP-glucuronosyltransferase 1a in rats.
    3. This study clarified that Ugt1a6 and Ugt1a7 mRNA expression and their enzyme activities were altered by beta-naphthoflavone, suggesting that these changes may lead to alteration in the pharmacokinetics of UGT substrate in rat brain.
      Title: Effects of β-Naphthoflavone on Ugt1a6 and Ugt1a7 Expression in Rat Brain.
    4. results indicate that adrenal-dependent factors such as glucocorticoids are partially involved in the basal regulation of UGT1A6 and UGT1A7 transcription.
      Title: Effect of adrenalectomy on expression and induction of UDP-glucuronosyltransferase 1A6 and 1A7 in rats.
    5. Catalytic properties/expression of UGT1A6/7 are influenced by the pro-oxidant environment in astrocytes.
      Title: Effect of oxidative stress on UDP-glucuronosyltransferases in rat astrocytes.
    6. We present for the first time evidences that the choroids plexus express transcripts for both UGT1A6 and NADPH-cytochrome P450 reductase
      Title: Drug metabolizing enzyme expression in rat choroid plexus: effects of in vivo xenobiotics treatment.
    7. These results indicate that the expression of extrahepatic UDP-glucuronosyltransferases UGT1a1 and UGT1a6 is isoform-specific and regulated differentially in tissues by the pituitary gland.
      Title: Effects on extrahepatic UDP-glucuronosyltransferases in hypophysectomized rat.
    8. Data suggest that thyroid hormones and vitamin A are co-regulators of UDP-glucuronosyltransferase (UGT) 1 expression, without affecting the UGT2 family.
      Title: Vitamin A modulates the effects of thyroid hormone on UDP-glucuronosyltransferase expression and activity in rat liver.
    9. The disulfide bond between Cys-121 and Cys-125 of UGT1A6 is responsible for the activation of glucuronidation in hepatic microsomes.
      Title: Activation of glucuronidation through reduction of a disulfide bond in rat UDP-glucuronosyltransferase 1A6.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124929

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucuronosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucuronosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables retinoic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 4-chlorobiphenyl metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular glucuronidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular glucuronidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to glucocorticoid stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in liver development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UDP-glucuronosyltransferase 1-6
    Names
    A1
    P-nitrophenol specific
    P-nitrophenol-specific UDPGT
    UDP glucuronosyltransferase 1 family, polypeptide A6
    UDP glucuronosyltransferase 1A6
    UDP glycosyltransferase 1 family, polypeptide A6
    UGT1*6
    UGT1-06
    UGT1.6
    NP_001034780.1
    NP_476446.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039691.3 → NP_001034780.1  UDP-glucuronosyltransferase 1-6 precursor

      See identical proteins and their annotated locations for NP_001034780.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JQH9, F7FJM7, P97886, Q6T5E9
      Related
      ENSRNOP00000030374.4, ENSRNOT00000032634.7
      Conserved Domains (2) summary
      PHA03392
      Location:14 → 504
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:26 → 521
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    2. NM_057105.3 → NP_476446.2  UDP-glucuronosyltransferase 1-6 precursor

      See identical proteins and their annotated locations for NP_476446.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC120922, BC107931
      UniProtKB/TrEMBL
      A6JQH9, F7FJM7, P97886, Q6T5E9
      Conserved Domains (2) summary
      PHA03392
      Location:14 → 504
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:26 → 521
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      96195018..96256264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08430.1 GenPept UniProtKB/Swiss-Prot:P08430

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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