TOMM34 translocase of outer mitochondrial membrane 34 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TOMM34provided by HGNC
Official Full Name: translocase of outer mitochondrial membrane 34provided by HGNC
Primary source: HGNC:HGNC:15746
See related: Ensembl:ENSG00000025772 MIM:616049; AllianceGenome:HGNC:15746
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TOM34; URCC3; HTOM34P
Summary: The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. [provided by RefSeq, Jul 2008]
Expression: Broad expression in testis (RPKM 58.9), adrenal (RPKM 15.3) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q13.12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (44942130..44960397, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (46677999..46696286, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (43570771..43589038, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TOMM34 promotes cell proliferation, migration, and invasion of OSCC and modulates mitochondrial function.
Title: TOMM34 promotes cell proliferation, migration, and invasion of OSCC and modulates mitochondrial function.
High Expression of Tomm34 and Its Correlations With Clinicopathology in Oral Squamous Cell Carcinoma.
Title: High Expression of Tomm34 and Its Correlations With Clinicopathology in Oral Squamous Cell Carcinoma.
Expression of TOMM34 and Its Clinicopathological Correlations in Urothelial Carcinoma of the Bladder.
Title: Expression of TOMM34 and Its Clinicopathological Correlations in Urothelial Carcinoma of the Bladder.
The interaction of the mitochondrial protein importer TOMM34 with HSP70 is regulated by TOMM34 phosphorylation and binding to 14-3-3 adaptors.
Title: The interaction of the mitochondrial protein importer TOMM34 with HSP70 is regulated by TOMM34 phosphorylation and binding to 14-3-3 adaptors.
Translocase of outer mitochondrial membrane 34 (Tomm34) is commonly expressed at high levels in epithelial ovarian cancers, except for the clear cell and mucinous subtypes. The expression of Tomm34 is positively correlated with FIGO stage. Tomm34 levels also indicates poor prognosis and progression for patients with mutant p53.
Title: Tomm34 is commonly expressed in epithelial ovarian cancer and associates with tumour type and high FIGO stage.
TOM34 and its partner HSP90AA1 might be used as a potential biomarker for monitoring HCV-induced hepatocellular carcinoma progression in the Egyptian population. Future large-scale validation studies are warranted.
Title: Overexpression of heat shock protein HSP90AA1 and translocase of the outer mitochondrial membrane TOM34 in HCV-induced hepatocellular carcinoma: A pilot study.
Data show that Tomm34 extensively interacts with the C-terminal structures of Hsp70 selectively in its ATP-bound state and that this interaction is strongly entropically driven.
Title: Novel Entropically Driven Conformation-specific Interactions with Tomm34 Protein Modulate Hsp70 Protein Folding and ATPase Activities.
These results suggest that Tomm34 represents a novel scaffolding co-chaperone of Hsp70 and Hsp90, which may facilitate Hsp70/Hsp90 cooperation during protein folding
Title: The assembly and intermolecular properties of the Hsp70-Tomm34-Hsp90 molecular chaperone complex.
TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome.
Title: TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome.
Results identify Tom34 as a cochaperone of Hsp70/Hsp90 in mitochondrial protein import.
Title: Tom34: a cytosolic cochaperone of the Hsp90/Hsp70 protein complex involved in mitochondrial protein import.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D20S540E (e-PCR)
- UniSTS:89935

RH119893 (e-PCR)
- UniSTS:133812

G62132 (e-PCR)
- UniSTS:139197

SHGC-31967 (e-PCR)
- UniSTS:1493

RH18281 (e-PCR)
- UniSTS:27632

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables heat shock protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in protein targeting to mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: mitochondrial import receptor subunit TOM34

Names: hTom34; outer mitochondrial membrane translocase (34kD); translocase of outer membrane 34 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006809.5 → NP_006800.2 mitochondrial import receptor subunit TOM34

See identical proteins and their annotated locations for NP_006800.2

Status: REVIEWED

Source sequence(s)

BC001763, BC006573, BC007423, BI560064

Consensus CDS

CCDS13340.1

UniProtKB/Swiss-Prot

Q15785, Q53GH9, Q6IBN7, Q9NTZ3

UniProtKB/TrEMBL

B4DXU3

Related

ENSP00000361900.3, ENST00000372813.4

Conserved Domains (2) summary

sd00006
Location:193 → 221

TPR; TPR repeat [structural motif]

cl26005
Location:12 → 294

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p14 Primary Assembly

Range

44942130..44960397 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011528501.2 → XP_011526803.1 mitochondrial import receptor subunit TOM34 isoform X1

UniProtKB/TrEMBL

B4DXU3

Conserved Domains (3) summary

sd00006
Location:167 → 195

TPR; TPR repeat [structural motif]

pfam00515
Location:203 → 234

TPR_1; Tetratricopeptide repeat

pfam13414
Location:166 → 231

TPR_11; TPR repeat
XM_017027600.3 → XP_016883089.1 mitochondrial import receptor subunit TOM34 isoform X2

Conserved Domains (3) summary

smart00028
Location:88 → 117

TPR; Tetratricopeptide repeats

sd00006
Location:9 → 37

TPR; TPR repeat [structural motif]

pfam13414
Location:10 → 82

TPR_11; TPR repeat

Alternate T2T-CHM13v2.0

Genomic

NC_060944.1 Alternate T2T-CHM13v2.0

Range

46677999..46696286 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054322868.1 → XP_054178843.1 mitochondrial import receptor subunit TOM34 isoform X1
XM_054322869.1 → XP_054178844.1 mitochondrial import receptor subunit TOM34 isoform X2