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    CELF2 CUGBP Elav-like family member 2 [ Homo sapiens (human) ]

    Gene ID: 10659, updated on 5-May-2024

    Summary

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    Official Symbol
    CELF2provided by HGNC
    Official Full Name
    CUGBP Elav-like family member 2provided by HGNC
    Primary source
    HGNC:HGNC:2550
    See related
    Ensembl:ENSG00000048740 MIM:602538; AllianceGenome:HGNC:2550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ETR3; DEE97; ETR-3; NAPOR; CELF-2; CUGBP2; BRUNOL3; CUG-BP2
    Summary
    Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in brain (RPKM 19.5), bone marrow (RPKM 16.3) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    10p14
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (10462550..11336675)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (10472957..11348760)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (10504513..11378674)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984207 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:10409107-10409607 Neighboring gene CELF2 divergent transript Neighboring gene NANOG hESC enhancer GRCh37_chr10:10570129-10570630 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2120 Neighboring gene NANOG hESC enhancer GRCh37_chr10:10631025-10631575 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2991 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:10693065-10693682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2121 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:10738713-10739255 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:10809675-10809828 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:10839838-10840532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:10840533-10841226 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:10846798-10847997 Neighboring gene NANOG hESC enhancer GRCh37_chr10:10862511-10863057 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:10872688-10873887 Neighboring gene ORMDL1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2122 Neighboring gene surfactant associated 1, lncRNA Neighboring gene long intergenic non-protein coding RNA 710 Neighboring gene uncharacterized LOC124902376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2123 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:11075383-11075893 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:11091414-11091914 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:11113336-11114535 Neighboring gene CELF2 antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2125 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2994 Neighboring gene Sharpr-MPRA regulatory region 12202 Neighboring gene Sharpr-MPRA regulatory region 4729 Neighboring gene NANOG hESC enhancer GRCh37_chr10:11224724-11225225 Neighboring gene uncharacterized LOC124902375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2999 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3005 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3008 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:11334439-11334940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3009 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:11334941-11335440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:11357313-11357819 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:11357820-11358325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3010 Neighboring gene uncharacterized LOC105376409 Neighboring gene CELF2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3011 Neighboring gene NANOG hESC enhancer GRCh37_chr10:11482790-11483302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:11485575-11486237 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:11486238-11486901 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3013 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:11493719-11494219 Neighboring gene uncharacterized LOC105376411 Neighboring gene USP6 N-terminal like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. De novo variants in CELF2 that disrupt the nuclear localization signal cause developmental and epileptic encephalopathy. Itai T, et al. Hum Mutat, 2021 Jan. PMID 33131106
    2. RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery. Chatrikhi R, et al. Cell Rep, 2019 Sep 10. PMID 31509743, Free PMC Article
    3. Epigenetic inactivation of the splicing RNA-binding protein CELF2 in human breast cancer. Piqué L, et al. Oncogene, 2019 Nov. PMID 31409895
    4. Pleotropic role of RNA binding protein CELF2 in autophagy induction. New J, et al. Mol Carcinog, 2019 Aug. PMID 31020708, Free PMC Article
    5. Aromatic side-chain conformational switch on the surface of the RNA Recognition Motif enables RNA discrimination. Diarra Dit Konté N, et al. Nat Commun, 2017 Sep 21. PMID 28935965, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of CELF2 in ferroptosis: Potential targets for cancer therapy (Review).
      Title: Role of CELF2 in ferroptosis: Potential targets for cancer therapy (Review).
    2. CircLIFR Inhibits Non-small Cell Lung Cancer Progression by Acting as a miR-429 Sponge to Enhance CELF2 Expression.
      Title: CircLIFR Inhibits Non-small Cell Lung Cancer Progression by Acting as a miR-429 Sponge to Enhance CELF2 Expression.
    3. Hypoxia-induced lncRNA MRVI1-AS1 accelerates hepatocellular carcinoma progression by recruiting RNA-binding protein CELF2 to stabilize SKA1 mRNA.
      Title: Hypoxia-induced lncRNA MRVI1-AS1 accelerates hepatocellular carcinoma progression by recruiting RNA-binding protein CELF2 to stabilize SKA1 mRNA.
    4. Natural Antisense Long Noncoding RNA HHIP-AS1 Suppresses Non-Small-Cell Lung Cancer Progression by Increasing HHIP Stability via Interaction with CELF2.
      Title: Natural Antisense Long Noncoding RNA HHIP-AS1 Suppresses Non-Small-Cell Lung Cancer Progression by Increasing HHIP Stability via Interaction with CELF2.
    5. MiR-210-3p targets CELF2 to facilitate progression of lung squamous carcinoma through PI3K/AKT pathway.
      Title: MiR-210-3p targets CELF2 to facilitate progression of lung squamous carcinoma through PI3K/AKT pathway.
    6. De novo variants in CELF2 that disrupt the nuclear localization signal cause developmental and epileptic encephalopathy.
      Title: De novo variants in CELF2 that disrupt the nuclear localization signal cause developmental and epileptic encephalopathy.
    7. miR-363-3p induces EMT via the Wnt/beta-catenin pathway in glioma cells by targeting CELF2.
      Title: miR-363-3p induces EMT via the Wnt/β-catenin pathway in glioma cells by targeting CELF2.
    8. LncRNA RHPN1-AS1 promotes the progression of nasopharyngeal carcinoma by targeting CELF2 expression.
      Title: LncRNA RHPN1-AS1 promotes the progression of nasopharyngeal carcinoma by targeting CELF2 expression.
    9. Genome-wide association analysis of cognitive function in Danish long-lived individuals.
      Title: Genome-wide association analysis of cognitive function in Danish long-lived individuals.
    10. LncRNA-SNHG16 promotes proliferation and migration of acute myeloid leukemia cells via PTEN/PI3K/AKT axis through suppressing CELF2 protein.
      Title: LncRNA-SNHG16 promotes proliferation and migration of acute myeloid leukemia cells via PTEN/PI3K/AKT axis through suppressing CELF2 protein.
    Submit: New GeneRIF Correction See all GeneRIFs (41)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Developmental and epileptic encephalopathy 97
    MedGen: C5561999 OMIM: 619561 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.
    EBI GWAS Catalog
    Genome-wide association study of liver enzymes in korean children.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pre-mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mRNA splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splice site recognition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of heart contraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Flemming body IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CUGBP Elav-like family member 2
    Names
    CUG triplet repeat RNA-binding protein 2
    CUG-BP- and ETR-3-like factor 2
    ELAV-type RNA-binding protein 3
    KDM2B/CELF2 fusion
    RNA-binding protein BRUNOL-3
    bruno-like protein 3
    neuroblastoma apoptosis-related RNA-binding protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025076.2 → NP_001020247.1  CUGBP Elav-like family member 2 isoform 1

      See identical proteins and their annotated locations for NP_001020247.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also called NAPOR-1) contains a distinct 5' UTR, lacks an alternate segment in the 3' UTR, and uses an alternate splice site in the 3' coding region, compared to variant 3. The resulting isoform (3) is shorter, has a shorter N-terminus, and includes an alternate segment near the C-terminus, compared to isoform 3.
      Source sequence(s)
      AA595891, AF036956, AF090694, BC050635, BQ213648, CN356737, DA310511, DA819821
      Consensus CDS
      CCDS41488.1
      UniProtKB/TrEMBL
      B2RA86
      Related
      ENSP00000404834.3, ENST00000417956.6
      Conserved Domains (4) summary
      TIGR01628
      Location:1 → 342
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12638
      Location:398 → 489
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:15 → 98
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:107 → 187
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    2. NM_001025077.3 → NP_001020248.1  CUGBP Elav-like family member 2 isoform 3

      See identical proteins and their annotated locations for NP_001020248.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also called NAPOR-3) represents the longest transcript and encodes isoform 3.
      Source sequence(s)
      AC026887, AL136320, AL136369, AL157704, KF573678
      Consensus CDS
      CCDS44354.1
      UniProtKB/Swiss-Prot
      B7ZAN9, O95319, Q7KYU4, Q8N499, Q92950, Q96NW9, Q96RQ5, Q96RQ6, Q9UL67
      UniProtKB/TrEMBL
      B2RA86
      Related
      ENSP00000406451.2, ENST00000416382.6
      Conserved Domains (3) summary
      cd12638
      Location:416 → 507
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:39 → 122
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:131 → 211
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    3. NM_001083591.1 → NP_001077060.1  CUGBP Elav-like family member 2 isoform 4

      See identical proteins and their annotated locations for NP_001077060.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also called NAPOR-4) contains a distinct 5' UTR, lacks an alternate segment in the 3' UTR, and uses an alternate splice site in the 3' coding region, compared to variant 3. The resulting isoform (3) is shorter, has a shorter N-terminus, and includes an alternate segment near the C-terminus, compared to isoform 3.
      Source sequence(s)
      AA595891, AF090694, AF432906, BC050635, BQ213648, CN356737, CR976278, DA310511, DA819821
      Consensus CDS
      CCDS44356.1
      UniProtKB/TrEMBL
      Q5VZZ6
      Related
      ENSP00000476999.1, ENST00000608830.5
      Conserved Domains (3) summary
      cd12638
      Location:396 → 487
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:15 → 98
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:107 → 187
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    4. NM_001326317.2 → NP_001313246.1  CUGBP Elav-like family member 2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136319, AL136320, AL136369, AL157704, AL583859, KF573678
      UniProtKB/TrEMBL
      B2RA86, B4DT00
      Conserved Domains (3) summary
      cd12638
      Location:392 → 483
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:15 → 98
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:107 → 187
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    5. NM_001326318.2 → NP_001313247.1  CUGBP Elav-like family member 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136319, AL136320, AL136369, AL157704, AL583859, KF573678
      Consensus CDS
      CCDS41488.1
      UniProtKB/TrEMBL
      B2RA86
      Conserved Domains (4) summary
      TIGR01628
      Location:1 → 342
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12638
      Location:398 → 489
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:15 → 98
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:107 → 187
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    6. NM_001326319.2 → NP_001313248.1  CUGBP Elav-like family member 2 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136319, AL136320, AL136369, AL157704, AL583859, KF573678
      UniProtKB/TrEMBL
      Q5VZZ6

    7. NM_001326320.2 → NP_001313249.1  CUGBP Elav-like family member 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136319, AL136320, AL136369, AL136452, AL157704, AL583859, KF573678
      Consensus CDS
      CCDS41488.1
      UniProtKB/TrEMBL
      B2RA86
      Conserved Domains (4) summary
      TIGR01628
      Location:1 → 342
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12638
      Location:398 → 489
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:15 → 98
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:107 → 187
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    8. NM_001326321.2 → NP_001313250.1  CUGBP Elav-like family member 2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136319, AL136320, AL136369, AL157704, AL583859, KF573678
      UniProtKB/TrEMBL
      Q5VZZ6

    9. NM_001326323.2 → NP_001313252.1  CUGBP Elav-like family member 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136319, AL136320, AL136369, AL136452, AL157704, AL583859, KF573678
      UniProtKB/TrEMBL
      Q5VZZ6

    10. NM_001326324.2 → NP_001313253.1  CUGBP Elav-like family member 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL136369, AL136452, AL157704, KF573678
      Consensus CDS
      CCDS41488.1
      UniProtKB/TrEMBL
      B2RA86
      Conserved Domains (4) summary
      TIGR01628
      Location:1 → 342
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12638
      Location:398 → 489
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:15 → 98
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:107 → 187
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    11. NM_001326325.2 → NP_001313254.1  CUGBP Elav-like family member 2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL136369, AL136452, AL157704, KF573678
      UniProtKB/TrEMBL
      B2RA86

    12. NM_001326326.2 → NP_001313255.1  CUGBP Elav-like family member 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL136369, AL136452, AL157704, KF573678
      Consensus CDS
      CCDS86070.1
      UniProtKB/TrEMBL
      A0A1B0GU44, B2RA86
      Related
      ENSP00000489955.1, ENST00000636488.1
      Conserved Domains (3) summary
      cd12638
      Location:428 → 519
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:51 → 134
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:143 → 223
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    13. NM_001326327.2 → NP_001313256.1  CUGBP Elav-like family member 2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL136369, AL136452, AL157704, KF573678
      Consensus CDS
      CCDS86069.1
      UniProtKB/TrEMBL
      A0A1B0GUN8, B2RA86
      Related
      ENSP00000490185.1, ENST00000637215.1
      Conserved Domains (4) summary
      TIGR01628
      Location:36 → 378
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12638
      Location:434 → 525
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:51 → 134
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:143 → 223
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    14. NM_001326328.2 → NP_001313257.1  CUGBP Elav-like family member 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL136369, AL136452, AL157704, KF573678
      Consensus CDS
      CCDS41488.1
      UniProtKB/TrEMBL
      B2RA86
      Related
      ENSP00000490401.1, ENST00000638035.1
      Conserved Domains (4) summary
      TIGR01628
      Location:1 → 342
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12638
      Location:398 → 489
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:15 → 98
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:107 → 187
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    15. NM_001326329.2 → NP_001313258.1  CUGBP Elav-like family member 2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL136369, AL157704, KF573678
      UniProtKB/TrEMBL
      B2RA86, B4DT00
      Conserved Domains (3) summary
      cd12638
      Location:392 → 483
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:15 → 98
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:107 → 187
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    16. NM_001326330.2 → NP_001313259.1  CUGBP Elav-like family member 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL136369, AL157704, KF573678
      Consensus CDS
      CCDS41488.1
      UniProtKB/TrEMBL
      B2RA86
      Conserved Domains (4) summary
      TIGR01628
      Location:1 → 342
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12638
      Location:398 → 489
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:15 → 98
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:107 → 187
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    17. NM_001326331.2 → NP_001313260.1  CUGBP Elav-like family member 2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL136369, AL157704, KF573678
      Consensus CDS
      CCDS86071.1
      UniProtKB/TrEMBL
      A0A0J9YX66, B4DS31
      Related
      ENSP00000488268.1, ENST00000631816.1
      Conserved Domains (4) summary
      TIGR01628
      Location:24 → 366
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12638
      Location:422 → 513
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:39 → 122
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:131 → 211
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    18. NM_001326332.2 → NP_001313261.1  CUGBP Elav-like family member 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL136369, AL157704, KF573678
      Consensus CDS
      CCDS44354.1
      UniProtKB/Swiss-Prot
      B7ZAN9, O95319, Q7KYU4, Q8N499, Q92950, Q96NW9, Q96RQ5, Q96RQ6, Q9UL67
      UniProtKB/TrEMBL
      B2RA86
      Related
      ENSP00000488582.1, ENST00000631460.1
      Conserved Domains (3) summary
      cd12638
      Location:416 → 507
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:39 → 122
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:131 → 211
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    19. NM_001326333.2 → NP_001313262.1  CUGBP Elav-like family member 2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL136369, AL157704, KF573678
      UniProtKB/Swiss-Prot
      O95319
      Conserved Domains (1) summary
      cd12638
      Location:194 → 285
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    20. NM_001326334.2 → NP_001313263.1  CUGBP Elav-like family member 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL136369, AL157704, KF573678
      Consensus CDS
      CCDS41488.1
      UniProtKB/TrEMBL
      B2RA86
      Conserved Domains (4) summary
      TIGR01628
      Location:1 → 342
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12638
      Location:398 → 489
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:15 → 98
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:107 → 187
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    21. NM_001326335.2 → NP_001313264.1  CUGBP Elav-like family member 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL136369, AL157704, KF573678
      UniProtKB/TrEMBL
      B4DS31
      Conserved Domains (3) summary
      cd12638
      Location:420 → 511
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:39 → 122
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:131 → 211
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    22. NM_001326336.2 → NP_001313265.1  CUGBP Elav-like family member 2 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL136369, AL157704, KF573678
      UniProtKB/TrEMBL
      Q5VZZ6

    23. NM_001326337.2 → NP_001313266.1  CUGBP Elav-like family member 2 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL136369, AL157704, KF573678
      UniProtKB/TrEMBL
      B4DS31
      Conserved Domains (3) summary
      cd12631
      Location:39 → 122
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:131 → 211
      RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12638
      Location:364 → 451
      RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    24. NM_001326338.2 → NP_001313267.1  CUGBP Elav-like family member 2 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL136369, KF573678
      Conserved Domains (4) summary
      cd12638
      Location:305 → 396
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      TIGR01661
      Location:15 → 392
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12634
      Location:20 → 100
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cl17169
      Location:1 → 11
      RRM_SF; RNA recognition motif (RRM) superfamily

    25. NM_001326339.2 → NP_001313268.1  CUGBP Elav-like family member 2 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL136369, KF573678
      UniProtKB/TrEMBL
      B4DIB6, Q5VZZ6
      Conserved Domains (4) summary
      cd12638
      Location:311 → 402
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      TIGR01661
      Location:15 → 398
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12634
      Location:20 → 100
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cl17169
      Location:1 → 11
      RRM_SF; RNA recognition motif (RRM) superfamily

    26. NM_001326340.2 → NP_001313269.1  CUGBP Elav-like family member 2 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL157704, AL162408, KF573678
      Consensus CDS
      CCDS86072.1
      UniProtKB/TrEMBL
      A0A0J9YXJ0, Q5VZZ6
      Related
      ENSP00000488422.1, ENST00000632065.1

    27. NM_001326341.2 → NP_001313270.1  CUGBP Elav-like family member 2 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL157704, AL162408, KF573678
      UniProtKB/TrEMBL
      B2RA86
      Conserved Domains (3) summary
      cd12638
      Location:423 → 514
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:46 → 129
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:138 → 218
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    28. NM_001326342.2 → NP_001313271.1  CUGBP Elav-like family member 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL157704, AL162408, KF573678
      Consensus CDS
      CCDS44355.1
      UniProtKB/TrEMBL
      B2RA86, E9PC62
      Related
      ENSP00000488690.1, ENST00000633077.2
      Conserved Domains (4) summary
      TIGR01628
      Location:31 → 373
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12638
      Location:429 → 520
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:46 → 129
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:138 → 218
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    29. NM_001326343.2 → NP_001313272.1  CUGBP Elav-like family member 2 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL157704, AL162408, KF573678
      UniProtKB/TrEMBL
      Q5VZZ6

    30. NM_001326344.2 → NP_001313273.1  CUGBP Elav-like family member 2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL157704, AL162408, KF573678
      UniProtKB/TrEMBL
      B2RA86, B4DT00
      Conserved Domains (3) summary
      cd12638
      Location:392 → 483
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:15 → 98
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:107 → 187
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    31. NM_001326345.2 → NP_001313274.1  CUGBP Elav-like family member 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL157704, AL162408, KF573678
      Consensus CDS
      CCDS41488.1
      UniProtKB/TrEMBL
      B2RA86
      Conserved Domains (4) summary
      TIGR01628
      Location:1 → 342
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12638
      Location:398 → 489
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:15 → 98
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:107 → 187
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    32. NM_001326346.2 → NP_001313275.1  CUGBP Elav-like family member 2 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, KF573678
      UniProtKB/TrEMBL
      B4DM66, B4DZ01
      Conserved Domains (2) summary
      cd12638
      Location:188 → 279
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      TIGR01661
      Location:88 → 275
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    33. NM_001326347.1 → NP_001313276.1  CUGBP Elav-like family member 2 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL157704
      UniProtKB/TrEMBL
      B4DDE7, Q5VZZ6
      Related
      ENSP00000476656.1, ENST00000609692.5
      Conserved Domains (3) summary
      cd12638
      Location:404 → 495
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:23 → 106
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:115 → 195
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    34. NM_001326348.2 → NP_001313277.1  CUGBP Elav-like family member 2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL157704, KF573678
      UniProtKB/TrEMBL
      B2RA86, B4DT00
      Conserved Domains (3) summary
      cd12638
      Location:392 → 483
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:15 → 98
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:107 → 187
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    35. NM_001326349.2 → NP_001313278.1  CUGBP Elav-like family member 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL157704, KF573678
      Consensus CDS
      CCDS41488.1
      UniProtKB/TrEMBL
      B2RA86
      Related
      ENSP00000382743.3, ENST00000399850.7
      Conserved Domains (4) summary
      TIGR01628
      Location:1 → 342
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12638
      Location:398 → 489
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:15 → 98
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:107 → 187
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    36. NM_001394502.1 → NP_001381431.1  CUGBP Elav-like family member 2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL136369, AL157704, KF573678
      Consensus CDS
      CCDS86071.1
      UniProtKB/TrEMBL
      A0A0J9YX66, B4DS31
      Conserved Domains (4) summary
      TIGR01628
      Location:24 → 366
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12638
      Location:422 → 513
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:39 → 122
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:131 → 211
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    37. NM_001394513.1 → NP_001381442.1  CUGBP Elav-like family member 2 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL157704, AL162408, KF573678
      UniProtKB/TrEMBL
      B2RA86
      Conserved Domains (3) summary
      cd12638
      Location:423 → 514
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:46 → 129
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:138 → 218
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    38. NM_001394517.1 → NP_001381446.1  CUGBP Elav-like family member 2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL157704, KF573678
      UniProtKB/TrEMBL
      B2RA86, B4DT00
      Conserved Domains (3) summary
      cd12638
      Location:392 → 483
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:15 → 98
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:107 → 187
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    39. NM_001394518.1 → NP_001381447.1  CUGBP Elav-like family member 2 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL157704, AL162408, KF573678
      UniProtKB/TrEMBL
      B2RA86
      Conserved Domains (3) summary
      cd12638
      Location:427 → 518
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:46 → 129
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:138 → 218
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    40. NM_001394519.1 → NP_001381448.1  CUGBP Elav-like family member 2 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC026887, AL136320, AL157704, AL162408, KF573678
      UniProtKB/TrEMBL
      B2RA86
      Conserved Domains (3) summary
      cd12638
      Location:427 → 518
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:46 → 129
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:138 → 218
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    41. NM_006561.4 → NP_006552.3  CUGBP Elav-like family member 2 isoform 2

      See identical proteins and their annotated locations for NP_006552.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also called NAPOR-2) contains a distinct 5' UTR, lacks an alternate segment in the 3' UTR, and uses an alternate splice site in the 3' coding region, compared to variant 3. The resulting isoform (2) is longer, has a distinct N-terminus, and includes an alternate segment near the C-terminus, compared to isoform 3.
      Source sequence(s)
      AC026887, AL136320, AL157704, AL162408, KF573678
      Consensus CDS
      CCDS44355.1
      UniProtKB/TrEMBL
      B2RA86, E9PC62
      Related
      ENSP00000443926.1, ENST00000542579.5
      Conserved Domains (4) summary
      TIGR01628
      Location:31 → 373
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12638
      Location:429 → 520
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:46 → 129
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:138 → 218
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      10462550..11336675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424494.1 → XP_047280450.1  CUGBP Elav-like family member 2 isoform X8

    2. XM_047424490.1 → XP_047280446.1  CUGBP Elav-like family member 2 isoform X8

    3. XM_047424501.1 → XP_047280457.1  CUGBP Elav-like family member 2 isoform X9

    4. XM_047424485.1 → XP_047280441.1  CUGBP Elav-like family member 2 isoform X4

    5. XM_047424484.1 → XP_047280440.1  CUGBP Elav-like family member 2 isoform X4

    6. XM_047424482.1 → XP_047280438.1  CUGBP Elav-like family member 2 isoform X1

    7. XM_047424483.1 → XP_047280439.1  CUGBP Elav-like family member 2 isoform X2

    8. XM_047424496.1 → XP_047280452.1  CUGBP Elav-like family member 2 isoform X8

    9. XM_047424492.1 → XP_047280448.1  CUGBP Elav-like family member 2 isoform X8

    10. XM_047424491.1 → XP_047280447.1  CUGBP Elav-like family member 2 isoform X8

    11. XM_047424499.1 → XP_047280455.1  CUGBP Elav-like family member 2 isoform X8

    12. XM_047424487.1 → XP_047280443.1  CUGBP Elav-like family member 2 isoform X6

    13. XM_047424506.1 → XP_047280462.1  CUGBP Elav-like family member 2 isoform X12

    14. XM_047424488.1 → XP_047280444.1  CUGBP Elav-like family member 2 isoform X7

    15. XM_047424508.1 → XP_047280464.1  CUGBP Elav-like family member 2 isoform X14

    16. XM_047424493.1 → XP_047280449.1  CUGBP Elav-like family member 2 isoform X8

    17. XM_047424500.1 → XP_047280456.1  CUGBP Elav-like family member 2 isoform X8

    18. XM_024447776.2 → XP_024303544.1  CUGBP Elav-like family member 2 isoform X3

      UniProtKB/TrEMBL
      B4DS31
      Conserved Domains (3) summary
      cd12638
      Location:426 → 517
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:39 → 122
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:131 → 211
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    19. XM_047424495.1 → XP_047280451.1  CUGBP Elav-like family member 2 isoform X8

    20. XM_047424486.1 → XP_047280442.1  CUGBP Elav-like family member 2 isoform X5

    21. XM_047424507.1 → XP_047280463.1  CUGBP Elav-like family member 2 isoform X13

    22. XM_047424502.1 → XP_047280458.1  CUGBP Elav-like family member 2 isoform X9

    23. XM_047424505.1 → XP_047280461.1  CUGBP Elav-like family member 2 isoform X11

      UniProtKB/TrEMBL
      B4DT00

    24. XM_047424504.1 → XP_047280460.1  CUGBP Elav-like family member 2 isoform X10

    25. XM_047424503.1 → XP_047280459.1  CUGBP Elav-like family member 2 isoform X9

      Related
      ENSP00000487802.1, ENST00000632728.1

    26. XM_047424498.1 → XP_047280454.1  CUGBP Elav-like family member 2 isoform X8

    27. XM_047424489.1 → XP_047280445.1  CUGBP Elav-like family member 2 isoform X8

    28. XM_047424509.1 → XP_047280465.1  CUGBP Elav-like family member 2 isoform X15

    29. XM_047424510.1 → XP_047280466.1  CUGBP Elav-like family member 2 isoform X16

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      10472957..11348760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364593.1 → XP_054220568.1  CUGBP Elav-like family member 2 isoform X8

    2. XM_054364589.1 → XP_054220564.1  CUGBP Elav-like family member 2 isoform X8

    3. XM_054364583.1 → XP_054220558.1  CUGBP Elav-like family member 2 isoform X4

    4. XM_054364582.1 → XP_054220557.1  CUGBP Elav-like family member 2 isoform X4

    5. XM_054364579.1 → XP_054220554.1  CUGBP Elav-like family member 2 isoform X1

    6. XM_054364580.1 → XP_054220555.1  CUGBP Elav-like family member 2 isoform X2

    7. XM_054364595.1 → XP_054220570.1  CUGBP Elav-like family member 2 isoform X8

    8. XM_054364586.1 → XP_054220561.1  CUGBP Elav-like family member 2 isoform X17

      UniProtKB/TrEMBL
      A0A1B0GU44

    9. XM_054364591.1 → XP_054220566.1  CUGBP Elav-like family member 2 isoform X8

    10. XM_054364590.1 → XP_054220565.1  CUGBP Elav-like family member 2 isoform X8

    11. XM_054364597.1 → XP_054220572.1  CUGBP Elav-like family member 2 isoform X8

    12. XM_054364585.1 → XP_054220560.1  CUGBP Elav-like family member 2 isoform X6

    13. XM_054364602.1 → XP_054220577.1  CUGBP Elav-like family member 2 isoform X12

    14. XM_054364587.1 → XP_054220562.1  CUGBP Elav-like family member 2 isoform X7

    15. XM_054364604.1 → XP_054220579.1  CUGBP Elav-like family member 2 isoform X14

    16. XM_054364592.1 → XP_054220567.1  CUGBP Elav-like family member 2 isoform X8

    17. XM_054364581.1 → XP_054220556.1  CUGBP Elav-like family member 2 isoform X3

    18. XM_054364594.1 → XP_054220569.1  CUGBP Elav-like family member 2 isoform X8

    19. XM_054364584.1 → XP_054220559.1  CUGBP Elav-like family member 2 isoform X5

    20. XM_054364603.1 → XP_054220578.1  CUGBP Elav-like family member 2 isoform X13

    21. XM_054364598.1 → XP_054220573.1  CUGBP Elav-like family member 2 isoform X9

    22. XM_054364601.1 → XP_054220576.1  CUGBP Elav-like family member 2 isoform X11

      UniProtKB/TrEMBL
      B4DT00

    23. XM_054364600.1 → XP_054220575.1  CUGBP Elav-like family member 2 isoform X10

    24. XM_054364599.1 → XP_054220574.1  CUGBP Elav-like family member 2 isoform X9

    25. XM_054364596.1 → XP_054220571.1  CUGBP Elav-like family member 2 isoform X8

    26. XM_054364588.1 → XP_054220563.1  CUGBP Elav-like family member 2 isoform X8

    27. XM_054364605.1 → XP_054220580.1  CUGBP Elav-like family member 2 isoform X15

    28. XM_054364606.1 → XP_054220581.1  CUGBP Elav-like family member 2 isoform X16

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95319.1 GenPept UniProtKB/Swiss-Prot:O95319

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