HFM1 DNA helicase [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: HFM1
Gene description: DNA helicase
Primary source: FungiDB:YGL251C
Locus tag: YGL251C
See related: SGD:S000003220; AllianceGenome:SGD:S000003220; VEuPathDB:YGL251C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MER3
Summary: Enables DNA helicase activity and heteroduplex DNA loop binding activity. Involved in DNA unwinding involved in DNA replication; meiosis I; and protein localization to site of double-strand break. Located in nucleus. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 9. Orthologous to human HFM1 (helicase for meiosis 1). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

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Biochemical characterisation of Mer3 helicase interactions and the protection of meiotic recombination intermediates.
Title: Biochemical characterisation of Mer3 helicase interactions and the protection of meiotic recombination intermediates.
Here the authors show that the budding yeast mismatch repair related MutLbeta complex, Mlh1-Mlh2, specifically interacts with the conserved meiotic Mer3 helicase, which recruits it to recombination hotspots, independently of mismatch recognition.
Title: Concerted action of the MutLβ heterodimer and Mer3 helicase regulates the global extent of meiotic gene conversion.
The MER3 transcript is dependent on wild-type Cbc2 for efficient splicing.
Title: Genetic interactions of hypomorphic mutations in the m7G cap-binding pocket of yeast nuclear cap binding complex: an essential role for Cbc2 in meiosis via splicing of MER3 pre-mRNA.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA unwinding involved in DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in homologous chromosome pairing at meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in resolution of meiotic recombination intermediates	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_011263.2

Meiosis specific DNA helicase; involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity

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