NMT1 glycylpeptide N-tetradecanoyltransferase NMT1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: NMT1
Gene description: glycylpeptide N-tetradecanoyltransferase NMT1
Primary source: FungiDB:YLR195C
Locus tag: YLR195C
See related: SGD:S000004185; AllianceGenome:SGD:S000004185; VEuPathDB:YLR195C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CDC72
Summary: Enables glycylpeptide N-tetradecanoyltransferase activity. Predicted to be involved in N-terminal peptidyl-glycine N-myristoylation. Located in cytosol. Orthologous to several human genes including NMT2 (N-myristoyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NMT1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (541937..543304, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Three crystal structures of Saccharomyces cerevisiae NMT: in binary complex with myristoyl-CoA (MYA) alone and in two ternary complexes.
Title: Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycylpeptide N-tetradecanoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycylpeptide N-tetradecanoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycylpeptide N-tetradecanoyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in N-terminal peptidyl-glycine N-myristoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-terminal peptidyl-glycine N-myristoylation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glycylpeptide N-tetradecanoyltransferase NMT1

NP_013296.1

EC 2.3.1.97

N-myristoyl transferase; catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

541937..543304 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182082.1 → NP_013296.1 TPA: glycylpeptide N-tetradecanoyltransferase NMT1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013296.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYJ8, P14743

UniProtKB/TrEMBL

A0A8H4BY74, B5VNB5, C7GIS7, N1P6S8

Conserved Domains (1) summary

COG5092
Location:1 → 455

NMT1; N-myristoyl transferase [Lipid metabolism]