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    LEW3 UDP-Glycosyltransferase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818610, updated on 7-Sep-2023

    Summary

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    Gene symbol
    LEW3
    Gene description
    UDP-Glycosyltransferase superfamily protein
    Primary source
    Araport:AT2G40190
    Locus tag
    AT2G40190
    See related
    TAIR:AT2G40190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    LEAF WILTING 3; T7M7.7; T7M7_7
    Summary
    Encodes a putative alpha-1,2-mannosyltransferase in N-linked glycoprotein (homologous to yeast ALG11). Plays vital roles in cell-wall biosynthesis and abiotic stress response. Located in endoplasmic reticulum membrane.
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    Genomic context

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    See LEW3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (16785173..16787590)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Stress induced protein Neighboring gene phosphatase 2C5 Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene Ribosomal protein L41 family Neighboring gene AGAMOUS-like 48

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LEW3, encoding a putative alpha-1,2-mannosyltransferase (ALG11) in N-linked glycoprotein, plays vital roles in cell-wall biosynthesis and the abiotic stress response in Arabidopsis thaliana. Zhang M, et al. Plant J, 2009 Dec. PMID 19732381
    2. A light-sensitive mutation in Arabidopsis LEW3 reveals the important role of N-glycosylation in root growth and development. Manzano C, et al. J Exp Bot, 2017 Nov 2. PMID 29106622
    3. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Positional cloning determined that lrg1 affects an alpha-1,2-mannosyltransferase gene, LEW3, involved in protein N-glycosylation. The lrg1 mutation causes a synonymous substitution that alters the correct splicing of the fourth intron in LEW3, causing a mix of wild-type and truncated protein. LRG1 RNA missplicing in roots and short root phenotypes in lrg1 are light-intensity dependent.
      Title: A light-sensitive mutation in Arabidopsis LEW3 reveals the important role of N-glycosylation in root growth and development.
    2. The lew3 mutation reduces protein glycosylation, impairs cellulose synthesis, and results in xylem collapse. lew3 mutants are more sensitive to salt stress and transpire less water than the wild-type.
      Title: LEW3, encoding a putative alpha-1,2-mannosyltransferase (ALG11) in N-linked glycoprotein, plays vital roles in cell-wall biosynthesis and the abiotic stress response in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_129577.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in oligosaccharide-lipid intermediate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    UDP-Glycosyltransferase superfamily protein
    NP_181548.2
    • LEAF WILTING 3 (LEW3); CONTAINS InterPro DOMAIN/s: Glycosyl transferase, group 1 (InterPro:IPR001296); BEST Arabidopsis thaliana protein match is: UDP-Glycosyltransferase superfamily protein (TAIR:AT1G78800.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16785173..16787590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129577.5 → NP_181548.2  UDP-Glycosyltransferase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181548.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IH01, Q0WT32, Q7DNH4, Q9XEE9
      UniProtKB/TrEMBL
      A0A178VPQ2, A0A384LKU0, A0A5S9X5N1, W8PUX5
      Conserved Domains (1) summary
      PLN02949
      Location:1 → 463
      PLN02949; transferase, transferring glycosyl groups
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XEE9.2

    Gene LinkOut

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