HB-3 homeobox-3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: HB-3
Gene description: homeobox-3
Primary source: Araport:AT2G33880
Locus tag: AT2G33880
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: homeobox-3; STIMPY; STIP; T1B8.31; T1B8_31; WOX9; WOX9A; WUSCHEL related homeobox 9A; WUSCHEL-RELATED HOMEOBOX 9
Summary: Encodes a protein with similarity to WUS type homeodomain protein. Required for meristem growth and development and acts through positive regulation of WUS. Loss of function phenotypes include embryo lethality, hyponastic cotyledons, reduced root development and smaller meristems. Phenotypes can be rescued by addition of sucrose in the growth media. Overexpression can partially rescue the triple mutant cytokinin receptor phenotype suggesting HB-3 is a downstream effector of cytokinin signaling.
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Genomic context

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See HB-3 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 4

Sequence:: Chromosome: 2; NC_003071.7 (14341355..14343796, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stip mutants show enhanced de-etiolation phenotype in response to cytokinin treatment in the dark, suggesting that STIP may be a negative regulator of cytokinin signaling under this condition.
Title: STIMPY mutants have increased cytokinin sensitivity during dark germination.
Expression of WOX8 is independent of the axis patterning signal auxin, but, together with the redundant gene WOX9, is activated in the zygote, its basal daughter cell, and the hypophysis by the zinc-finger transcription factor WRKY2.
Title: Transcriptional activation of Arabidopsis axis patterning genes WOX8/9 links zygote polarity to embryo development.
cytokinin signaling is involved in activation of the homeobox gene STIMPY (STIP or WOX9) expression in meristematic tissues, which is essential for maintaining the meristematic fate
Title: STIMPY mediates cytokinin signaling during shoot meristem establishment in Arabidopsis seedlings.
Complete loss of STIP activity results in early embryonic arrest, most likely due to a failure in cell division.
Title: Combinations of WOX activities regulate tissue proliferation during Arabidopsis embryonic development.
STIMPY (STIP; also called WOX9) is a homeobox gene required for the growth of the vegetative shoot apical meristem, in part by positively regulating WUSCHEL protein expression. [STIMPY] [STIP] [WOX9]
Title: Requirement of homeobox gene STIMPY/WOX9 for Arabidopsis meristem growth and maintenance.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001336476.1

Supported by ESTs:

NM_128948.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of meristem growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cytokinin	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: homeobox-3

NP_180944.2

homeobox-3 (HB-3); CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057); BEST Arabidopsis thaliana protein match is: WUSCHEL related homeobox 8 (TAIR:AT5G45980.1); Has 671 Blast hits to 615 proteins in 76 species: Archae - 0; Bacteria - 0; Metazoa - 25; Fungi - 22; Plants - 589; Viruses - 0; Other Eukaryotes - 35 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

14341355..14343796 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_128948.4 → NP_180944.2 homeobox-3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_180944.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O23662, Q6X7J4, Q8GX13

Conserved Domains (1) summary

pfam00046
Location:54 → 114

Homeobox; Homeobox domain
NM_001336476.1 → NP_001324695.1 homeobox-3 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VQA8, A0A1P8B0W7, A0A384KQD3

Conserved Domains (1) summary

pfam00046
Location:54 → 114

Homeobox; Homeobox domain