Fabp7 fatty acid binding protein 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fabp7provided by RGD
Official Full Name: fatty acid binding protein 7provided by RGD
Primary source: RGD:69312
See related: Ensembl:ENSRNOG00000000814 AllianceGenome:RGD:69312
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable fatty acid binding activity. Involved in epithelial cell proliferation. Located in cytoplasm and nucleus. Orthologous to human FABP7 (fatty acid binding protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 1507.3) and Brain (RPKM 463.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 20q12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (37667125..37673299)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (37123193..37126725)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (40769624..40773156)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results of the xenograft model assay showed that exogenous BLBP also stimulated tumor formation and downregulated p21 and p16. In conclusion, our study demonstrated that exogenous BLBP promoted proliferation of the C6 cells in vitro and facilitated tumor formation in vivo. Therefore, BLBP expression in glioma cells may promote cell growth by inhibiting the tumor suppressors.
Title: Brain lipid-binding protein promotes proliferation and modulates cell cycle in C6 rat glioma cells.
The data of this study suggested that regional accumulations of FABP7+ astrocytes may represent reservoirs of cells having the potential for neurogenesis.
Title: Astrocyte fatty acid binding protein-7 is a marker for neurogenic niches in the rat hippocampus.
Fabp7 is a downstream gene of Pax6 transcription factor in the developing rat cortex and essential for maintenance of neuroepithelial cells during early cortical development.
Title: Role of Fabp7, a downstream gene of Pax6, in the maintenance of neuroepithelial cells during early embryonic development of the rat cortex.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid binding	TAS Traceable Author Statement more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell proliferation in forebrain	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neurogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prepulse inhibition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within startle response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fatty acid-binding protein, brain

Names: B-FABP; BLBP; brain lipid-binding protein; brain-type fatty acid-binding protein; fatty acid binding protein 7, brain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030832.2 → NP_110459.1 fatty acid-binding protein, brain

See identical proteins and their annotated locations for NP_110459.1

Status: PROVISIONAL

Source sequence(s)

U02096

UniProtKB/Swiss-Prot

P55051

UniProtKB/TrEMBL

A6K4D4, A6K4D5

Related

ENSRNOP00000001079.4, ENSRNOT00000001079.6

Conserved Domains (1) summary

cl10502
Location:2 → 131

lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

37667125..37673299

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279555.1 → XP_063135625.1 fatty acid-binding protein, brain isoform X1

UniProtKB/Swiss-Prot

P55051

UniProtKB/TrEMBL

A6K4D4
XM_063279556.1 → XP_063135626.1 fatty acid-binding protein, brain isoform X1

UniProtKB/Swiss-Prot

P55051

UniProtKB/TrEMBL

A6K4D4