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    blvra biliverdin reductase A [ Danio rerio (zebrafish) ]

    Gene ID: 767661, updated on 11-Apr-2024

    Summary

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    Official Symbol
    blvraprovided by ZNC
    Official Full Name
    biliverdin reductase Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060929-312
    See related
    Ensembl:ENSDARG00000059857 AllianceGenome:ZFIN:ZDB-GENE-060929-312
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:153046
    Summary
    Predicted to enable biliberdin reductase NAD+ activity; biliverdin reductase (NADP+) activity; and zinc ion binding activity. Predicted to act upstream of or within heme catabolic process. Predicted to be located in cytoplasm. Is expressed in brain; gill; hematopoietic system; and liver. Orthologous to human BLVRA (biliverdin reductase A). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See blvra in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (49844630..49860704, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (50110400..50126474, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101882528 Neighboring gene WD repeat domain 48b Neighboring gene cytochrome C oxidase assembly factor 1 Neighboring gene HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of heme oxygenase and biliverdin reductase gene expression in zebrafish (Danio rerio): Basal expression and response to pro-oxidant exposures. Holowiecki A, et al. Toxicol Appl Pharmacol, 2016 Nov 15. PMID 27671773, Free PMC Article
    2. Spatiotemporal expression and transcriptional regulation of heme oxygenase and biliverdin reductase genes in zebrafish (Danio rerio) suggest novel roles during early developmental periods of heightened oxidative stress. Holowiecki A, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2017 Jan. PMID 27760386, Free PMC Article
    3. High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins. Niksirat H, et al. J Proteome Res, 2021 Aug 6. PMID 34185526
    4. Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development. Cannon JE, et al. Mech Dev, 2013 Feb. PMID 23072875, Free PMC Article
    5. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Suggest that Gata-1 and Nrf2a play differential roles in regulating the heme degradation enzymes hmox1a/bvra/bvrb during an early developmental period of heightened cellular stress
      Title: Spatiotemporal expression and transcriptional regulation of heme oxygenase and biliverdin reductase genes in zebrafish (Danio rerio) suggest novel roles during early developmental periods of heightened oxidative stress.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC153046

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables biliberdin reductase NAD+ activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables biliverdin reductase (NAD(P)H) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables biliverdin reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within heme catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heme catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    biliverdin reductase A
    NP_001070069.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076601.1 → NP_001070069.1  biliverdin reductase A

      See identical proteins and their annotated locations for NP_001070069.1

      Status: PROVISIONAL

      Source sequence(s)
      BC124225
      UniProtKB/TrEMBL
      Q08CI5
      Related
      ENSDARP00000078125.5, ENSDART00000083690.6
      Conserved Domains (3) summary
      COG0673
      Location:1 → 146
      MviM; Predicted dehydrogenase [General function prediction only]
      pfam01408
      Location:5 → 120
      GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
      pfam09166
      Location:128 → 237
      Biliv-reduc_cat; Biliverdin reductase, catalytic

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      49844630..49860704 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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