gatad2b GATA zinc finger domain containing 2B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gatad2bprovided by ZNC
Official Full Name: GATA zinc finger domain containing 2Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060503-655
See related: Ensembl:ENSDARG00000005834 AllianceGenome:ZFIN:ZDB-GENE-060503-655
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkeyp-66g8.1
Summary: Predicted to enable sequence-specific DNA binding activity and zinc ion binding activity. Acts upstream of or within negative regulation of smoothened signaling pathway. Predicted to be located in nucleus. Predicted to be part of NuRD complex. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 18. Orthologous to human GATAD2B (GATA zinc finger domain containing 2B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 19

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (41641534..41729786)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (42056471..42144647)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of NuRD complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: transcriptional repressor p66-beta

Names: transcription repressor p66-like

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044975.1 → NP_001038440.1 transcriptional repressor p66-beta

See identical proteins and their annotated locations for NP_001038440.1

Status: PROVISIONAL

Source sequence(s)

CR388201

UniProtKB/TrEMBL

A0A8M1N9R4

Related

ENSDARP00000036714.8, ENSDART00000033362.9

Conserved Domains (2) summary

pfam00320
Location:440 → 474

GATA; GATA zinc finger

pfam16563
Location:164 → 200

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007130.7 Reference GRCz11 Primary Assembly

Range

41641534..41729786

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005159747.4 → XP_005159804.1 transcriptional repressor p66-beta isoform X1

See identical proteins and their annotated locations for XP_005159804.1

UniProtKB/TrEMBL

A0A8M1N9R4

Conserved Domains (2) summary

pfam00320
Location:440 → 474

GATA; GATA zinc finger

pfam16563
Location:164 → 200

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2