kdr kinase insert domain receptor (a type III receptor tyrosine kinase) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kdrprovided by ZNC
Official Full Name: kinase insert domain receptor (a type III receptor tyrosine kinase)provided by ZNC
Primary source: ZFIN:ZDB-GENE-041001-112
See related: Ensembl:ENSDARG00000017321 AllianceGenome:ZFIN:ZDB-GENE-041001-112
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: flk1; kdrb; flk1b; vegfr2b; wu:fc31a09; si:ch211-254j6.1; si:busm1-205d10.1; si:ch211-278f21.4
Summary: Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within angiogenesis. Predicted to be located in endoplasmic reticulum. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including axis; endocardium; intermediate cell mass of mesoderm; tail bud; and vasculature. Human ortholog(s) of this gene implicated in several diseases, including adhesions of uterus; artery disease (multiple); gastrointestinal system cancer (multiple); macular degeneration (multiple); and pancreatic cancer (multiple). Orthologous to human KDR (kinase insert domain receptor). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Note: The name of this locus was changed from kdrb to kdr to conform to the name reported by the Zebrafish Information Network. [28 Jul 2008]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (22220988..22277544)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (22321315..22377871)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intronic Flk1 genetic enhancer element directs arterial-specific expression via RBPJ-mediated venous repression.
Title: An Intronic Flk1 Enhancer Directs Arterial-Specific Expression via RBPJ-Mediated Venous Repression.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to vascular endothelial growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in endothelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: vascular endothelial growth factor receptor 2

Names: FLK-1b; VEGFR-2 homolog B; fetal liver kinase 1b; kinase insert domain receptor (a type III receptor tyrosine kinase), b; kinase insert domain receptor-B; protein-tyrosine kinase receptor flk-1b; vascular endothelial growth factor receptor 2 homolog B

NP_001019824.2

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024653.2 → NP_001019824.2 vascular endothelial growth factor receptor 2 precursor

See identical proteins and their annotated locations for NP_001019824.2

Status: PROVISIONAL

Source sequence(s)

DQ026829

UniProtKB/Swiss-Prot

B3DJQ0, Q1ANK7, Q5GIT4, Q5MD88, Q5RIP2, Q5TZ34

Related

ENSDARP00000049203.6, ENSDART00000049204.7

Conserved Domains (9) summary

cd05864
Location:356 → 429

Ig2_VEGFR-2; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 2 (VEGFR-2)

smart00408
Location:691 → 753

IGc2; Immunoglobulin C-2 Type

smart00409
Location:571 → 654

IG; Immunoglobulin

smart00410
Location:233 → 331

IG_like; Immunoglobulin like

pfam07679
Location:677 → 763

I-set; Immunoglobulin I-set domain

pfam07714
Location:843 → 1171

Pkinase_Tyr; Protein tyrosine kinase

pfam13895
Location:143 → 221

Ig_2; Immunoglobulin domain

cl11960
Location:241 → 335

Ig; Immunoglobulin domain

cl21453
Location:835 → 1178

PKc_like; Protein Kinases, catalytic domain