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    lnx2a ligand of numb-protein X 2a [ Danio rerio (zebrafish) ]

    Gene ID: 553331, updated on 27-Mar-2024

    Summary

    Official Symbol
    lnx2aprovided by ZNC
    Official Full Name
    ligand of numb-protein X 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060228-2
    See related
    Ensembl:ENSDARG00000029177 AllianceGenome:ZFIN:ZDB-GENE-060228-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    lnx2
    Summary
    Enables ubiquitin protein ligase activity. Acts upstream of or within exocrine pancreas development and protein phosphopantetheinylation. Is expressed in central nervous system; endoderm; and pancreatic system. Orthologous to human LNX2 (ligand of numb-protein X 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    See lnx2a in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (21646264..21674999, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (21501140..21529822, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 Neighboring gene general transcription factor IIIA, b Neighboring gene si:ch211-140b10.6 Neighboring gene pancreatic and duodenal homeobox 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General protein information

    Preferred Names
    ligand of Numb protein X 2; ligand of Numb protein X 2a
    Names
    ligand of numb-protein X 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113225.2NP_001106696.2  ligand of Numb protein X 2a

      Status: VALIDATED

      Source sequence(s)
      BG305543, BX571696, DT867995, EB950577, EB957408, EH583415, FJ156085
      UniProtKB/TrEMBL
      A0A8M1NFK9, B6DRF5, F1R5N4
      Related
      ENSDARP00000046210.5, ENSDART00000046211.8
      Conserved Domains (3) summary
      smart00228
      Location:267353
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:646730
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam13639
      Location:4987
      zf-RING_2; Ring finger domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      21646264..21674999 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470169.1XP_021325844.1  ligand of Numb protein X 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PLS6, B6DRF5
      Conserved Domains (1) summary
      cd00992
      Location:537621
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    2. XM_021470170.1XP_021325845.1  ligand of Numb protein X 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PXH3
      Conserved Domains (1) summary
      cd00992
      Location:496580
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    3. XM_021470171.1XP_021325846.1  ligand of Numb protein X 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PU28
      Conserved Domains (5) summary
      smart00228
      Location:267353
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:375455
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd16780
      Location:4488
      mRING-HC-C3HC3D_LNX2; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 2 (LNX2)
      cl00117
      Location:515565
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
      cl26688
      Location:44201
      DWNN; DWNN domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395171.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      316958..344056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)