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    BOLA-NC1 non-classical MHC class I antigen [ Bos taurus (cattle) ]

    Gene ID: 510417, updated on 6-Jun-2024

    Summary

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    Gene symbol
    BOLA-NC1
    Gene description
    non-classical MHC class I antigen
    See related
    Ensembl:ENSBTAG00000002069
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    BoLA; BoLA-NC
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    Genomic context

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    See BOLA-NC1 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (28541135..28552334, complement)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene mitochondrial import receptor subunit TOM20 homolog Neighboring gene major histocompatibility complex, class I Neighboring gene BOLA class I histocompatibility antigen, alpha chain BL3-7-like Neighboring gene uncharacterized LOC132343678 Neighboring gene uncharacterized LOC104975666 Neighboring gene uncharacterized LOC132343677 Neighboring gene MHC Class I JSP.1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A BAC contig of approximately 400 kb contains the classical class I major histocompatibility complex (MHC) genes of cattle. Di Palma F, et al. Eur J Immunogenet, 2002 Feb. PMID 11841492
    2. Non-classical major histocompatibility complex class makes a crucial contribution to reproduction in the dairy cow. Shu L, et al. J Reprod Dev, 2012. PMID 22785322
    3. cDNA sequence of cattle MHC class I genes transcribed in serologically defined haplotypes A18 and A31. Ellis SA, et al. Immunogenetics, 1996. PMID 8550100
    4. A novel RNAseq-assisted method for MHC class I genotyping in a non-model species applied to a lethal vaccination-induced alloimmune disease. Demasius W, et al. BMC Genomics, 2016 May 17. PMID 27188848, Free PMC Article
    5. Evolution of major histocompatibility complex class I genes in Cetartiodactyls. Holmes EC, et al. Immunogenetics, 2003 Jul. PMID 12756505

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC134252

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables peptide antigen binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    non-classical MHC class I antigen
    Names
    MHC class I antigen
    MHC class I heavy chain
    non-MHC class I antigen
    non-classical MHC class I antigen NC1*00601

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105616.2 → NP_001099086.1  non-classical MHC class I antigen precursor

      See identical proteins and their annotated locations for NP_001099086.1

      Status: PROVISIONAL

      Source sequence(s)
      BC109706
      UniProtKB/TrEMBL
      H6V5G3, Q2TBT0
      Conserved Domains (2) summary
      cd07698
      Location:204 → 296
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:22 → 200
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      28541135..28552334 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059880287.1 → XP_059736270.1  non-classical MHC class I antigen isoform X1

    2. XM_059880288.1 → XP_059736271.1  non-classical MHC class I antigen isoform X3

      UniProtKB/TrEMBL
      F1N4Y5

    3. XM_005223618.5 → XP_005223675.1  non-classical MHC class I antigen isoform X2

      UniProtKB/TrEMBL
      F1N4Y5
      Related
      ENSBTAP00000021451.7, ENSBTAT00000021451.7
      Conserved Domains (3) summary
      cd07698
      Location:204 → 295
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:22 → 200
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      pfam06623
      Location:296 → 322
      MHC_I_C; MHC_I C-terminus

    4. XM_005223620.5 → XP_005223677.1  non-classical MHC class I antigen isoform X6

      UniProtKB/TrEMBL
      Q3YFG6
      Conserved Domains (3) summary
      cd07698
      Location:204 → 295
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:22 → 200
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      pfam06623
      Location:296 → 322
      MHC_I_C; MHC_I C-terminus

    5. XM_059880290.1 → XP_059736273.1  non-classical MHC class I antigen isoform X5

      UniProtKB/TrEMBL
      A0A0K1L4Z1, H6V5G4

    6. XM_059880289.1 → XP_059736272.1  non-classical MHC class I antigen isoform X4

      UniProtKB/TrEMBL
      H6V5G4
    Nucleotide Protein Strain
    Heading Accession and Version

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    Research Materials