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    Cspg5 chondroitin sulfate proteoglycan 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50568, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Cspg5provided by RGD
    Official Full Name
    chondroitin sulfate proteoglycan 5provided by RGD
    Primary source
    RGD:2431
    See related
    Ensembl:ENSRNOG00000020833 AllianceGenome:RGD:2431
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ngc; Caleb
    Summary
    Involved in cytoskeleton organization; neurogenesis; and positive regulation of substrate adhesion-dependent cell spreading. Predicted to be located in Golgi apparatus and Golgi-associated vesicle membrane. Predicted to be active in GABA-ergic synapse and glutamatergic synapse. Predicted to be integral component of postsynaptic membrane. Orthologous to human CSPG5 (chondroitin sulfate proteoglycan 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 449.2) and Adrenal (RPKM 22.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cspg5 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (119098932..119113191)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (110220506..110234766)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (118333695..118348040)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480238 Neighboring gene small nucleolar RNA SNORA43 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 Neighboring gene ribosomal protein S23, pseudogene 11 Neighboring gene elongator acetyltransferase complex subunit 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Repeated cocaine administration alters the expression of genes in corticolimbic circuitry after a 3-week withdrawal: a DNA macroarray study. Toda S, et al. J Neurochem, 2002 Sep. PMID 12358776
    2. Neuroglycan C, a neural tissue-specific transmembrane chondroitin sulfate proteoglycan, in retinal neural network formation. Inatani M, et al. Invest Ophthalmol Vis Sci, 2000 Dec. PMID 11095636
    3. Neuroglycan C, a novel membrane-spanning chondroitin sulfate proteoglycan that is restricted to the brain. Watanabe E, et al. J Biol Chem, 1995 Nov 10. PMID 7592931
    4. Chondroitin sulfate proteoglycan-5 forms perisynaptic matrix assemblies in the adult rat cortex. Pintér A, et al. Cell Signal, 2020 Oct. PMID 32653642
    5. The neural EGF family member CALEB/NGC mediates dendritic tree and spine complexity. Brandt N, et al. EMBO J, 2007 May 2. PMID 17431398, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chondroitin sulfate proteoglycan-5 forms perisynaptic matrix assemblies in the adult rat cortex.
      Title: Chondroitin sulfate proteoglycan-5 forms perisynaptic matrix assemblies in the adult rat cortex.
    2. Rac1, Cdc42, and RhoG perform very specific and non-redundant functions at different levels of hierarchy in regulating dendritic tree complexity induced by CALEB/NGC
      Title: Different roles of the small GTPases Rac1, Cdc42, and RhoG in CALEB/NGC-induced dendritic tree complexity.
    3. PI3K-Akt-mammalian target of rapamycin (mTOR) signaling pathway and PKC are important for CALEB/NGC-induced stimulation of dendritic branching. CALEB/NGC-induced spine morphogenesis is independent of PI3K but depends on PKC.
      Title: The neural EGF family member CALEB/NGC mediates dendritic tree and spine complexity.
    4. there is a glycosylation site for chondroitin sulfate on the neural part-time proteoglycan, neuroglycan C
      Title: Glycosylation site for chondroitin sulfate on the neural part-time proteoglycan, neuroglycan C.
    5. neuroglycan C is a novel component of midkine receptors involved in process elongation
      Title: Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cell projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glial cell projection elongation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi-associated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi-associated vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi-associated vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    chondroitin sulfate proteoglycan 5
    Names
    acidic leucine-rich EGF-like domain-containing brain protein
    neuroglycan C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019284.3 → NP_062157.2  chondroitin sulfate proteoglycan 5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region, compared to variant 2. This results in a shorter protein (isoform 1), compared to isoform 2.
      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      F1M4R7
      Conserved Domains (2) summary
      pfam06566
      Location:34 → 281
      Chon_Sulph_att; Chondroitin sulphate attachment domain
      pfam06567
      Location:452 → 543
      Neural_ProG_Cyt; Neural chondroitin sulphate proteoglycan cytoplasmic domain

    2. NM_133652.2 → NP_598413.1  chondroitin sulfate proteoglycan 5 isoform 2 precursor

      See identical proteins and their annotated locations for NP_598413.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longer isoform (2).
      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q62831, Q9ERQ6
      UniProtKB/TrEMBL
      F1M4R7
      Related
      ENSRNOP00000028278.8, ENSRNOT00000028278.8
      Conserved Domains (2) summary
      pfam06566
      Location:33 → 278
      Chon_Sulph_att; Chondroitin sulphate attachment domain
      pfam06567
      Location:452 → 570
      Neural_ProG_Cyt; Neural chondroitin sulphate proteoglycan cytoplasmic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      119098932..119113191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERQ6.1 GenPept UniProtKB/Swiss-Prot:Q9ERQ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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