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    AFF4 ALF transcription elongation factor 4 [ Canis lupus familiaris (dog) ]

    Gene ID: 474678, updated on 5-Mar-2024

    Summary

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    Official Symbol
    AFF4provided by VGNC
    Official Full Name
    ALF transcription elongation factor 4provided by VGNC
    Primary source
    VGNC:VGNC:37688
    See related
    Ensembl:ENSCAFG00845011722
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See AFF4 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 11 NC_051815.1 (21945075..22033184, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 11 NC_006593.4 (19960642..20053417, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 11 NC_049232.1 (21153663..21241674, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 11 NC_049271.1 (20663430..20751443, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 11 NC_049752.1 (20511144..20599256, complement)

    Chromosome 11 - NC_051815.1Genomic Context describing neighboring genes Neighboring gene ubiquinol-cytochrome c reductase complex III subunit VII Neighboring gene liver enriched antimicrobial peptide 2 Neighboring gene uncharacterized LOC111098022 Neighboring gene zinc finger CCHC-type containing 10 Neighboring gene U4 spliceosomal RNA Neighboring gene heat shock protein family A (Hsp70) member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of super elongation complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AF4/FMR2 family member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051815.1 Reference ROS_Cfam_1.0

      Range
      21945075..22033184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038681504.1 → XP_038537432.1  AF4/FMR2 family member 4 isoform X2

      UniProtKB/TrEMBL
      A0A8C0JJ70, A0A8C0RZP2
      Conserved Domains (2) summary
      pfam05110
      Location:2 → 450
      AF-4; AF-4 proto-oncoprotein
      pfam18876
      Location:870 → 1133
      AF-4_C; AF-4 proto-oncoprotein C-terminal region

    2. XM_038681503.1 → XP_038537431.1  AF4/FMR2 family member 4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JJ70, A0A8C0QAS7, A0A8I3NGB0
      Related
      ENSCAFP00845016341.1, ENSCAFT00845020819.1
      Conserved Domains (2) summary
      pfam05110
      Location:2 → 479
      AF-4; AF-4 proto-oncoprotein
      pfam18876
      Location:899 → 1162
      AF-4_C; AF-4 proto-oncoprotein C-terminal region

    3. XM_038681502.1 → XP_038537430.1  AF4/FMR2 family member 4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JJ70, A0A8C0QAS7, A0A8I3NGB0
      Conserved Domains (2) summary
      pfam05110
      Location:2 → 479
      AF-4; AF-4 proto-oncoprotein
      pfam18876
      Location:899 → 1162
      AF-4_C; AF-4 proto-oncoprotein C-terminal region

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049271.1 Alternate UMICH_Zoey_3.1

      Range
      20663430..20751443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038490068.1 → XP_038345996.1  AF4/FMR2 family member 4 isoform X2

      Conserved Domains (2) summary
      pfam05110
      Location:2 → 450
      AF-4; AF-4 proto-oncoprotein
      pfam18876
      Location:870 → 1133
      AF-4_C; AF-4 proto-oncoprotein C-terminal region

    2. XM_038490067.1 → XP_038345995.1  AF4/FMR2 family member 4 isoform X1

      Conserved Domains (2) summary
      pfam05110
      Location:2 → 479
      AF-4; AF-4 proto-oncoprotein
      pfam18876
      Location:899 → 1162
      AF-4_C; AF-4 proto-oncoprotein C-terminal region

    3. XM_038490066.1 → XP_038345994.1  AF4/FMR2 family member 4 isoform X1

      Conserved Domains (2) summary
      pfam05110
      Location:2 → 479
      AF-4; AF-4 proto-oncoprotein
      pfam18876
      Location:899 → 1162
      AF-4_C; AF-4 proto-oncoprotein C-terminal region

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049752.1 Alternate UNSW_CanFamBas_1.0

      Range
      20511144..20599256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038616009.1 → XP_038471937.1  AF4/FMR2 family member 4 isoform X2

      Conserved Domains (2) summary
      pfam05110
      Location:2 → 450
      AF-4; AF-4 proto-oncoprotein
      pfam18876
      Location:870 → 1133
      AF-4_C; AF-4 proto-oncoprotein C-terminal region

    2. XM_038616008.1 → XP_038471936.1  AF4/FMR2 family member 4 isoform X1

      Conserved Domains (2) summary
      pfam05110
      Location:2 → 479
      AF-4; AF-4 proto-oncoprotein
      pfam18876
      Location:899 → 1162
      AF-4_C; AF-4 proto-oncoprotein C-terminal region

    3. XM_038616007.1 → XP_038471935.1  AF4/FMR2 family member 4 isoform X1

      Conserved Domains (2) summary
      pfam05110
      Location:2 → 479
      AF-4; AF-4 proto-oncoprotein
      pfam18876
      Location:899 → 1162
      AF-4_C; AF-4 proto-oncoprotein C-terminal region

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049232.1 Alternate UU_Cfam_GSD_1.0

      Range
      21153663..21241674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038552148.1 → XP_038408076.1  AF4/FMR2 family member 4 isoform X2

      UniProtKB/TrEMBL
      A0A8C0JJ70, A0A8C0RZP2
      Conserved Domains (2) summary
      pfam05110
      Location:2 → 450
      AF-4; AF-4 proto-oncoprotein
      pfam18876
      Location:870 → 1133
      AF-4_C; AF-4 proto-oncoprotein C-terminal region

    2. XM_038552147.1 → XP_038408075.1  AF4/FMR2 family member 4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JJ70, A0A8C0QAS7, A0A8I3NGB0
      Conserved Domains (2) summary
      pfam05110
      Location:2 → 479
      AF-4; AF-4 proto-oncoprotein
      pfam18876
      Location:899 → 1162
      AF-4_C; AF-4 proto-oncoprotein C-terminal region

    3. XM_038552146.1 → XP_038408074.1  AF4/FMR2 family member 4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JJ70, A0A8C0QAS7, A0A8I3NGB0
      Conserved Domains (2) summary
      pfam05110
      Location:2 → 479
      AF-4; AF-4 proto-oncoprotein
      pfam18876
      Location:899 → 1162
      AF-4_C; AF-4 proto-oncoprotein C-terminal region

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006593.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      19960642..20053417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038669281.1 → XP_038525209.1  AF4/FMR2 family member 4 isoform X2

      UniProtKB/TrEMBL
      A0A8C0JJ70, A0A8C0RZP2
      Conserved Domains (2) summary
      pfam05110
      Location:2 → 450
      AF-4; AF-4 proto-oncoprotein
      pfam18876
      Location:870 → 1133
      AF-4_C; AF-4 proto-oncoprotein C-terminal region

    2. XM_038669272.1 → XP_038525200.1  AF4/FMR2 family member 4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JJ70, A0A8C0QAS7, A0A8I3NGB0
      Conserved Domains (2) summary
      pfam05110
      Location:2 → 479
      AF-4; AF-4 proto-oncoprotein
      pfam18876
      Location:899 → 1162
      AF-4_C; AF-4 proto-oncoprotein C-terminal region

    3. XM_038669263.1 → XP_038525191.1  AF4/FMR2 family member 4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JJ70, A0A8C0QAS7, A0A8I3NGB0
      Conserved Domains (2) summary
      pfam05110
      Location:2 → 479
      AF-4; AF-4 proto-oncoprotein
      pfam18876
      Location:899 → 1162
      AF-4_C; AF-4 proto-oncoprotein C-terminal region
    Nucleotide Protein
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