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    AR androgen receptor [ Ovis aries (sheep) ]

    Gene ID: 443042, updated on 5-Mar-2024

    Summary

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    Gene symbol
    AR
    Gene description
    androgen receptor
    See related
    EnsemblRapid:ENSOARG00020019886
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) X NC_056080.1 (60048753..60244465)

    Chromosome X - NC_056080.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 3-like Neighboring gene NADH-ubiquinone oxidoreductase chain 1-like Neighboring gene transfer RNA tyrosine (anticodon GUA) Neighboring gene oligophrenin 1 Neighboring gene small nucleolar RNA SNORA79 Neighboring gene uncharacterized LOC132658727 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056080.1 Chromosome X Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Postnatal changes in testicular development and androgen receptors immunolocalization in D'Man ram lambs. Boukenaoui N, et al. Folia Histochem Cytobiol, 2012 Apr 24. PMID 22532134
    2. Ontogeny of androgen receptor expression in the ovine fetal central nervous system and pituitary. Wood CE, et al. Neurosci Lett, 2008 Jul 11. PMID 18514409, Free PMC Article
    3. Expression of androgen receptor and estrogen receptor-alpha in the developing pituitary gland of male sheep lamb. Huang LB, et al. Anim Reprod Sci, 2011 Sep. PMID 21880440
    4. Expression and distribution of P450-aromatase in the ovine hypothalamus at different stages of fetal development. Mura A, et al. Neuro Endocrinol Lett, 2010. PMID 21173749
    5. Ontogeny of estrogen receptor alpha, estrogen receptor beta and androgen receptor, and their co-localization with Islet-1 in the dorsal root ganglia of sheep fetuses during gestation. Luo H, et al. Histochem Cell Biol, 2008 Apr. PMID 18204852

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. androgen receptors detected with immunohistochemistry were located in the nuclei and cytoplasm of adenohypophysis cells, and only in nuclei of testis cells (Leydig, Sertoli, peritubular myoid and germ cells)
      Title: Postnatal changes in testicular development and androgen receptors immunolocalization in D'Man ram lambs.
    2. Both AR and ERalpha are important in regulation of secretary function of anterior pituitary in sheep lamb.
      Title: Expression of androgen receptor and estrogen receptor-alpha in the developing pituitary gland of male sheep lamb.
    3. The highest aromatase and androgen receptor amounts were observed at 35GD and 55GD, when aromatase was more abundant in females than in males
      Title: Expression and distribution of P450-aromatase in the ovine hypothalamus at different stages of fetal development.
    4. expression of androgen receptor occurs in fetal brain and pituitary, and that the abundance of the AR is ontogenetically regulated.
      Title: Ontogeny of androgen receptor expression in the ovine fetal central nervous system and pituitary.
    5. Ontogeny of AR and its co-localization with Islet-1 in the dorsal root ganglia of sheep fetuses during gestation is reported.
      Title: Ontogeny of estrogen receptor alpha, estrogen receptor beta and androgen receptor, and their co-localization with Islet-1 in the dorsal root ganglia of sheep fetuses during gestation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in androgen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in male gonad development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    androgen receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308584.1 → NP_001295513.1  androgen receptor

      See identical proteins and their annotated locations for NP_001295513.1

      Status: PROVISIONAL

      Source sequence(s)
      KF227907
      UniProtKB/TrEMBL
      A0A6P9FR47, A0A835ZMY4, S5U7M4
      Related
      ENSOARP00020025428.1, ENSOART00020030780.2
      Conserved Domains (3) summary
      cd07073
      Location:643 → 888
      NR_LBD_AR; Ligand binding domain of the nuclear receptor androgen receptor, ligand activated transcription regulator
      cd07173
      Location:525 → 606
      NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers
      pfam02166
      Location:6 → 429
      Androgen_recep; Androgen receptor

    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056080.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      60048753..60244465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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