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    CG10000 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43394, updated on 10-May-2024

    Summary

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    Official Symbol
    CG10000provided by FlyBase
    Primary source
    FLYBASE:FBgn0039596
    Locus tag
    Dmel_CG10000
    See related
    AllianceGenome:FB:FBgn0039596
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10000; dppGalNAcT10
    Summary
    Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Involved in multicellular organism reproduction. Predicted to be active in Golgi apparatus. Is expressed in embryonic/larval midgut. Orthologous to human GALNT14 (polypeptide N-acetylgalactosaminyltransferase 14) and GALNT16 (polypeptide N-acetylgalactosaminyltransferase 16). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG10000 in Genome Data Viewer
    Location:
    98E3-98E3; 3-97 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28748384..28751661, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24574106..24577383, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene huntingtin Neighboring gene Allatostatin A receptor 2 Neighboring gene uncharacterized protein Neighboring gene aquarius

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family is spatially and temporally regulated during Drosophila development. Tian E, et al. Glycobiology, 2006 Feb. PMID 16251381
    2. Functional characterization and expression analysis of members of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family from Drosophila melanogaster. Ten Hagen KG, et al. J Biol Chem, 2003 Sep 12. PMID 12829714
    3. Multiple members of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family are essential for viability in Drosophila. Tran DT, et al. J Biol Chem, 2012 Feb 17. PMID 22157008, Free PMC Article
    4. Dissecting the biological role of mucin-type O-glycosylation using RNA interference in Drosophila cell culture. Zhang L, et al. J Biol Chem, 2010 Nov 5. PMID 20807760, Free PMC Article
    5. An O-glycosyltransferase promotes cell adhesion during development by influencing secretion of an extracellular matrix integrin ligand. Zhang L, et al. J Biol Chem, 2010 Jun 18. PMID 20371600, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in oligosaccharide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sexual reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10000-PA
    NP_651630.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      28748384..28751661 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143373.3 → NP_651630.3  uncharacterized protein Dmel_CG10000 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651630.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MYY6, Q9VAT9
      UniProtKB/TrEMBL
      H8F4S3
      Related
      FBpp0084684
      Conserved Domains (2) summary
      cd02510
      Location:113 → 422
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:435 → 548
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MYY6.2 Q8MYY6

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