leo1 LEO1 homolog, Paf1/RNA polymerase II complex component [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: leo1provided by ZNC
Official Full Name: LEO1 homolog, Paf1/RNA polymerase II complex componentprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2435
See related: Ensembl:ENSDARG00000055357 AllianceGenome:ZFIN:ZDB-GENE-040426-2435
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77374
Summary: Predicted to enable RNA polymerase II C-terminal domain phosphoserine binding activity. Acts upstream of or within several processes, including animal organ development; melanocyte differentiation; and xanthophore differentiation. Located in nucleus. Part of Cdc73/Paf1 complex. Is expressed in brain; eye; immature eye; pharyngeal arch; and somite. Orthologous to human LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (39292911..39321466, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (39311903..39340458, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results indicate that antagonistic regulation of gene expression by PAF1Cand p-TEFb plays a crucial role in oligodendrocyte development in the CNS.
Title: Antagonistic regulation of PAF1C and p-TEFb is required for oligodendrocyte differentiation.
These results provide the first genetic evidence of the requirement for Leo1 in the development of the heart and neural crest cell populations.
Title: The PAF1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA polymerase II C-terminal domain phosphoserine binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within melanocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spinal cord oligodendrocyte cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription elongation by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within xanthophore differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cdc73/Paf1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of Cdc73/Paf1 complex	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RNA polymerase-associated protein LEO1

Names: Leo1, Paf1/RNA polymerase II complex component, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207067.1 → NP_996950.1 RNA polymerase-associated protein LEO1

See identical proteins and their annotated locations for NP_996950.1

Status: PROVISIONAL

Source sequence(s)

BC066443

UniProtKB/Swiss-Prot

Q6NYV9

Related

ENSDARP00000072160.3, ENSDART00000077694.4

Conserved Domains (2) summary

PHA02664
Location:161 → 260

PHA02664; hypothetical protein; Provisional

pfam04004
Location:352 → 510

Leo1; Leo1-like protein