NTRK1 neurotrophic receptor tyrosine kinase 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: NTRK1provided by CGNC
Full Name: neurotrophic receptor tyrosine kinase 1provided by CGNC
Primary source: CGNC:49757
See related: Ensembl:ENSGALG00010028736
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: trkA; CTRKA
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	25	NC_052556.1 (1076976..1084637)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	25	NC_052597.1 (1078022..1085686)

Chromosome 25 - NC_052556.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results suggest that TrkA activation may play an important role in the survival of OT neurons subjected to acute hypoxia.
Title: NGF, TrkA-P and neuroprotection after a hypoxic event in the developing central nervous system.
These findings suggest that by interacting with PlexA4, TrkA plays a crucial role in redirecting local Sema3A signaling to retrograde axonal transport, thereby regulating dendritic GluA2 localization and patterning.
Title: TrkA mediates retrograde semaphorin 3A signaling through plexin A4 to regulate dendritic branching.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables neurotrophin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables neurotrophin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to nerve growth factor stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in nerve growth factor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: high affinity nerve growth factor receptor

Names: neurotrophic tyrosine kinase, receptor, type 1; trk-A; tropomyosin receptor kinase

NP_990709.2

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205378.2 → NP_990709.2 high affinity nerve growth factor receptor precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000349

UniProtKB/TrEMBL

H9KZZ1, Q90699

Related

ENSGALP00010042803.1, ENSGALT00010069542.1

Conserved Domains (4) summary

smart00082
Location:138 → 184

LRRCT; Leucine rich repeat C-terminal domain

smart00409
Location:194 → 274

IG; Immunoglobulin

cd05092
Location:498 → 777

PTKc_TrkA; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A

sd00031
Location:83 → 106

LRR_1; leucine-rich repeat [structural motif]