calb2b calbindin 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: calb2bprovided by ZNC
Official Full Name: calbindin 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1668
See related: Ensembl:ENSDARG00000036344 AllianceGenome:ZFIN:ZDB-GENE-040426-1668
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: calb2; zgc:73099; wu:fq17g09
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of long-term synaptic potentiation and regulation of presynaptic cytosolic calcium ion concentration. Predicted to be active in several cellular components, including cytosol; dendrite; and terminal bouton. Is expressed in several structures, including head; nervous system; neural rod; neural tube; and sensory epithelial cell. Orthologous to human CALB2 (calbindin 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (24681278..24699946, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (24410121..24428789, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Perturbed development of calb2b expressing dI6 interneurons and motor neurons underlies locomotor defects observed in calretinin knock-down zebrafish larvae.
Title: Perturbed development of calb2b expressing dI6 interneurons and motor neurons underlies locomotor defects observed in calretinin knock-down zebrafish larvae.
Calb2a and Calb2b are highly conserved across vertebrate species and originated from the same ancestral gene long back in the evolution. Homology modeling and docking with the similar structure and Ca(2+) binding sites for both proteins provide the evidence that both the proteins may have similar function and one can compensate for the loss of other.
Title: Knockdown of calcium-binding calb2a and calb2b genes indicates the key regulator of the early development of the zebrafish, Danio rerio.
Downregulation of CRT gene may cause omphalocele in the Cd chick model by disrupting CRT-mediated Ca(2+) signaling and AJs.
Title: Disruption of calreticulin-mediated cellular adhesion signaling in the cadmium-induced omphalocele in the chick model.
The present study shows that CR-ir changes during lamprey spinal cord development in different types of neurons, sometimes in opposite ways.
Title: Developmental changes of calretinin immunoreactivity in the lamprey spinal cord.
the presence of calretinin in amacrine and ganglion cells is a conserved feature along vertebrate phylogeny and bipoly cell.
Title: Immunocytochemical study of calretinin and calbindin D-28K expression in the retina of three cartilaginous fishes and a cladistian (Polypterus).
The distribution of calretinin in mechanosensory (neuromasts of the lateral line system; maculae and cristae ampullaris of the inner ear) and chemosensory (superficial and oral taste buds; olfactory epithelium) cells in adult zebrafish (Danio rerio).
Title: Differential distribution of S100 protein and calretinin in mechanosensory and chemosensory cells of adult zebrafish (Danio rerio).
pattern of expression in the retina at different developmental stages, as well as during optic nerve regeneration
Title: Differential expression of calretinin in the developing and regenerating zebrafish visual system.
Calretinin (CD) is a marker of various neuronal populations distributed throughout the brainstem, as well as of characteristic tracts of fibers and neuropil. CR may prove useful for characterizing a number of neuronal subpopulations in zebrafish.
Title: Calretinin immunoreactivity in the brain of the zebrafish, Danio rerio: distribution and comparison with some neuropeptides and neurotransmitter-synthesizing enzymes. II. Midbrain, hindbrain, and rostral spinal cord.
CR immunocytochemistry revealed patterns of fibers and neuropil in several telencephalic and diencephalic regions, indicating that it is a useful marker for characterizing neural centers, pathways, and neuronal subpopulations in the zebrafish forebrain.
Title: Calretinin immunoreactivity in the brain of the zebrafish, Danio rerio: distribution and comparison with some neuropeptides and neurotransmitter-synthesizing enzymes. I. Olfactory organ and forebrain.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of long-term synaptic potentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: calbindin 2b

Names: calbindin 2, (calretinin); calretinin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200711.1 → NP_957005.1 calbindin 2b

See identical proteins and their annotated locations for NP_957005.1

Status: PROVISIONAL

Source sequence(s)

BC059467

UniProtKB/TrEMBL

Q6PC56

Related

ENSDARP00000052801.4, ENSDART00000052802.5

Conserved Domains (3) summary

PTZ00184
Location:13 → 178

PTZ00184; calmodulin; Provisional

cd00051
Location:109 → 178

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:155 → 218

EF-hand_7; EF-hand domain pair